Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.80.1.7829605PMID 7829605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of an alternate promoter in the rat androgen-binding protein/sex hormone-binding globulin gene that regulates synthesis of a messenger RNA encoding a protein with altered function.

  1993cited by this paper
• Sex hormone‐binding globulin, androgen‐binding protein, and vitamin K‐dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein

  1992cited by this paper
• Hormone-associated variation of the glycan microheterogeneity pattern of human sex steroid-binding protein (hSBP).

  1991cited by this paper
• Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing.

  1991cited by this paper
• Effects of hormones on SBP mRNA levels in human cancer cells.

  1991cited by this paper
• The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function.

  1991cited by this paper
• The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones.

  1990cited by this paper
• Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells.

  1990cited by this paper
• Biologically active steroids activate receptor-bound human sex hormone-binding globulin to cause LNCaP cells to accumulate adenosine 3',5'-monophosphate.

  1990cited by this paper
• Regulation of sex hormone-binding globulin production by growth factors.

  1990cited by this paper
• The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances.

  1990cited by this paper
• Estrogen and androgen regulation of sex hormone binding globulin secretion by a human liver cell line.

  1990cited by this paper
• Immunocytochemical localization of the sex hormone-binding globulin in a human hepatoma cell line.

  1989cited by this paper
• Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.

  1989cited by this paper
• The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.

  1989cited by this paper
• Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.

  1988cited by this paper
• Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin.

  1988cited by this paper
• The cDNA‐deduced primary structure of human sex hormone‐binding globulin and location of its steroid‐binding domain

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Sex hormone-binding globulin secretion by human hepatocarcinoma cells is increased by both estrogens and androgens.

  1987cited by this paper
• Hormonal control of SBP in human hepatoma cells.

  1986cited by this paper
• Function of glycoprotein glycans.

  1985cited by this paper
• A recognition system for sex-hormone-binding protein-estradiol complex in human decidual endometrium plasma membranes.

  1984cited by this paper
• Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell line.

  1984cited by this paper
• Effect of tunicamycin and monensin on secretion of thyroxine-binding globulin by cultured human hepatoma (Hep G2) cells.

  1984cited by this paper
• A direct solubilization procedure for the determination of DNA and protein in cultured fibroblast monolayers.

  1983cited by this paper
• Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.

  1981cited by this paper
• Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line.

  1981cited by this paper
• Immunocytochemical localization of the sex steroid-binding protein of plasma in tissues of the adult monkey Macaca nemestrina.

  1980cited by this paper
• Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

  1977cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper
• Changed surface glycoprotein as a marker of malignancy in human leukaemic cells

  1975cited by this paper
• Sex-Hormone-Binding Globulin is an Oestrogen Amplifier

  1972cited by this paper
• Microheterogeneity of the testosterone binding globulin of human pregnancy serum demonstrated by isoelectric focusing.

  1969cited by this paper

• Sex steroids, SHBG and type 2 diabetes in women: what do we really know?

  2026cites this paper
• Sex Hormone-Binding Globulin and Metabolic Syndrome in Children and Adolescents: A Focus on Puberty

  2025cites this paper
• Relationship between Serum Sex Hormones and Coronary Artery Disease in Premenopausal Women – A Missing Link?

  2023cites this paper
• Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of Plasma Among Young Sedentary Males

  2023cites this paper
• Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity

  2021cites this paper
• The Role of Estrone in Feminizing Hormone Treatment

  2021cites this paper
• Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

  2020cites this paper
• Sex Hormone-Binding Globulin: Regulation and Role as a Marker of Chronic Disease Risk

  2019influential citation
• Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men

  2018cites this paper
• Hormonal (Cortical-Gonadotropic Axis) and Physical Changes With Two Years Intense Exercise Training in Elite Young Soccer Players

  2017cites this paper
• Sex Hormone-Binding Globulin in Children and Adolescents

  2016cites this paper
• Androgens and Female Sexual Function and Dysfunction--Findings From the Fourth International Consultation of Sexual Medicine.

  2016cites this paper
• Successful Pregnancy after Improving Insulin Resistance with the Glucagon-Like Peptide-1 Analogue in a Woman with Polycystic Ovary Syndrome: A Case Report and Review of the Literature

  2016cites this paper
• Functional characterization of sex hormone-binding globulin genetic polymorphism

  2015cites this paper
• Neighborhood Socioeconomic Status During Childhood Versus Puberty in Relation to Endogenous Sex Hormone Levels in Adult Women

  2015cites this paper
• Novel insights in SHBG regulation and clinical implications.

  2015cites this paper
• Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58).

  2014influential citation
• Systematic review: endocrine abnormalities in patients with liver cirrhosis.

  2014cites this paper
• Sex hormone-binding globulin gene expression and insulin resistance.

  2014cites this paper
• Immunologic and mass-spectrometric estimates of SHBG concentrations in healthy women.

  2014cites this paper
• Changes of Estradiol (E2) Concentration and Sex Hormone Binding Globulin (SHBG) Concentration in Serum during Controlled Ovarian Hyperstimulation (COH) in Pregnant and Non-pregnant Women

  2014cites this paper
• Biological significance of a thyroid hormone-regulated secretome.

  2013cites this paper
• Relationships between adiponectin, sex hormone binding globulin and insulin resistance in hyperthyroid Graves' disease women.

  2013cites this paper
• Effect of bilateral oophorectomy on adrenocortical function in women with polycystic ovary syndrome.

  2013cites this paper
• SHBG Is an Important Factor in Stemness Induction of Cells by DHT In Vitro and Associated with Poor Clinical Features of Prostate Carcinomas

  2013cites this paper
• Association of anthropometric, androgenic and insulin-related features with polymorphisms in exon 8 of SHBG gene in women with polycystic ovary syndrome

  2013cites this paper
• Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women.

  2012cites this paper
• The contribution of SHBG to the variation in HOMA‐IR is not dependent on endogenous oestrogen or androgen levels in postmenopausal women

  2012cites this paper
• Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes.

  2011cites this paper
• REGULATION OF ANDROGEN ACTION BY SEX HORMONE-BINDING GLOBULIN

  2011cites this paper
• Reproductive hormones and obesity: 9 years of observation from the Study of Women's Health Across the Nation.

  2010cites this paper
• Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome.

  2010cites this paper
• The Role of Insulin-Sensitizing Agents in the Treatment of Polycystic Ovary Syndrome

  2009cites this paper
• Endemic Fungal Infections in Patients Receiving Tumour Necrosis Factor-α Inhibitor Therapy

  2009cites this paper
• Longitudinal Analysis of the Pubertal Growth, Body Composition, and Endocrine Development in Young People with and without Diabetes

  2009cites this paper
• Direct inhibition of ERK1/2 phosphorylation as a possible mechanism for the antiproliferative action of 3,4-diOH-PCB3 in the MCF-7 cell line.

  2009cites this paper
• Subclinical impairment of left ventricular function in young obese women: contributions of polycystic ovary disease and insulin resistance.

  2008influential citation
• Sex Hormone Binding Globulin and Aging

  2008cites this paper
• Associations between sex hormone binding globulin and metabolic syndrome parameters in premenopausal obese women.

  2008cites this paper
• Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.

  2007cites this paper
• Levels in Danish Population Surveys Secular Decline in Male Testosterone and Sex Hormone Binding Globulin Serum

  2007cites this paper
• Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys.

  2007influential citation
• Current Approaches to the Diagnosis and Treatment of Polycystic Ovarian Syndrome in Youth

  2007cites this paper
• Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations.

  2007cites this paper
• An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)

  2007influential citation
• Effect of insulin sensitivity on SHBG levels in premenopausal versus postmenopausal obese women

  2007cites this paper
• Serum sex hormone-binding globulin levels show too much variability to be used effectively as a screening marker for insulin resistance in women with polycystic ovary syndrome.

  2006cites this paper
• Sex Hormone–Binding Globulin and the Free Androgen Index Are Related to Cardiovascular Risk Factors in Multiethnic Premenopausal and Perimenopausal Women Enrolled in the Study of Women Across the Nation (SWAN)

  2005cites this paper
• Racial difference in circulating sex hormone-binding globulin levels in prepubertal boys.

  2005cites this paper
• A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer

  2005cites this paper
• Gonadal dysfunction in systemic diseases.

  2005cites this paper
• INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS-1 AND -3 AND SEX HORMONE-BINDING GLOBULIN: STUDIES ON REGULATION OF SYNTHESIS IN VITRO, AND CLINICAL ASPECTS

  2005influential citation
• Testosterone, SHBG, and the Metabolic Cardiovascular Syndrome

  2004cites this paper
• [The heart and androgens].

  2004cites this paper
• Influence of fecal isoflavone degradation phenotype on bioavailability of soybean isoflavones in women

  2004cites this paper
• Current controversies in testosterone testing: aging and obesity.

  2004cites this paper
• Male Hypogonadism

  2004cites this paper
• Childhood obesity and hormonal abnormalities associated with cancer risk

  2004cites this paper
• Cœur et androgènes

  2004cites this paper
• alpha -melanocyte-stimulating hormone is a novel regulator of bone.

  2003cites this paper
• First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus.

  2003cites this paper
• Metabolic Profile in Patients with Benign Prostate Hyperplasia or Prostate Cancer and Normal Glucose Tolerance

  2003cites this paper
• Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin and insulin-like growth factors in human hepatoma cells.

  2003cites this paper
• Insulin resistance, hemostatic factors, and hormone interactions in pre- and perimenopausal women: SWAN.

  2003cites this paper
• Association of endogenous sex hormones and insulin resistance among postmenopausal women: results from the Postmenopausal Estrogen/Progestin Intervention Trial.

  2003cites this paper
• First trimester insulin resistance and subsequent preeclampsia: a prospective study.

  2002cites this paper
• The association of breast mitogens with mammographic densities

  2002cites this paper
• Regulation of sex hormone-binding globulin secretion in human hepatoma G2 cells.

  2001cites this paper
• Racial disparities in metabolism, central obesity, and sex hormone-binding globulin in postmenopausal women.

  2001cites this paper
• Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin.

  2001cites this paper
• Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children.

  2000cites this paper
• Regulation of Human Sex Hormone-Binding Globulin Gene (

  2000cites this paper
• Synthesis and regulation of sex hormone-binding globulin in obesity

  2000cites this paper
• Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women.

  2000cites this paper
• Sex hormone binding globulin expression and colocalization with estrogen receptor in the human Fallopian tube.

  1999cites this paper
• Estradiol increases the production of sex hormone-binding globulin but not insulin-like growth factor binding protein-1 in cultured human hepatoma cells.

  1999cites this paper
• Ligand regulation of juvenile hormone binding protein mRNA in mutant Manduca sexta.

  1999cites this paper
• Secretion and Metabolism of Steroids in Primate Mammals During Pregnancy

  1998cites this paper
• Effect of medroxyprogesterone acetate on sex hormone-binding globulin mRNA expression in the human endometrial cancer cell line Ishikawa.

  1998cites this paper
• Hepatocyte Nuclear Factor-4 Controls Transcription from a TATA-less Human Sex Hormone-binding Globulin Gene Promoter*

  1998cites this paper
• Modulation of T3-induced sex hormone-binding globulin secretion by human hepatoblastoma cells.

  1997cites this paper
• Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: The Telecom Study.

  1997cites this paper
• Phyto-oestrogens and Western diseases.

  1997cites this paper
• Expression and function of thyroid hormone receptor variants in normal and chronically diseased human liver.

  1996cites this paper
• Acute and chronic regulation of serum sex hormone-binding globulin levels by plasma insulin concentrations in male noninsulin-dependent diabetes mellitus patients.

  1996cites this paper
• Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures.

  1995cites this paper
• Regulation of sex hormone-binding globulin secretion and gene expression by cycloheximide in vitro.

  1995cites this paper