Adiponectin promotes endothelial progenitor cell number and function

Obesity‐linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose‐derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN‐KO) in response to hindlimb ischemia. Adenovirus‐mediated delivery of adiponectin increased EPC levels in both WT and APN‐KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity‐related cardiovascular disorders.

• Publication year

  2008

• Venue

  FEBS Letters

• Publication date

  2008-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2008.04.006PMID 18423403PMCID PMC2435501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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