Integrity of XIAP is essential for effective activity recovery of apoptosome and its downstream caspases by Smac/Diablo.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  International Journal of Biological Macromolecules

• Publication date

  2017-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ijbiomac.2017.03.088PMID 28322955
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy

  2015cited by this paper
• Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome

  2014cited by this paper
• Small-molecule SMAC mimetics as new cancer therapeutics.

  2014cited by this paper
• Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9*

  2013cited by this paper
• A mechanistic insight into caspase-7 inhibition by BIR1-2 domains of XIAP and cIAP1

  2012cited by this paper
• The intersection between DNA damage response and cell death pathways.

  2012cited by this paper
• Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis

  2011cited by this paper
• The Leucine Zipper Domains of the Transcription Factors GCN4 and c-Jun Have Ribonuclease Activity

  2010cited by this paper
• BIR2 domain of XIAP plays a marginal role in inhibition of executioner caspases.

  2010cited by this paper
• The Apaf‐1•procaspase‐9 apoptosome complex functions as a proteolytic‐based molecular timer

  2009cited by this paper
• Design of Small‐Molecule Peptidic and Nonpeptidic Smac Mimetics

  2009cited by this paper
• Design of small-molecule peptidic and nonpeptidic Smac mimetics.

  2008cited by this paper
• A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases.

  2008cited by this paper
• XIAP Activity Dictates Apaf-1 Dependency for Caspase 9 Activation

  2007cited by this paper
• Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.

  2007cited by this paper
• IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007cited by this paper
• Caspase-9 cleavage, do you need it?

  2007cited by this paper
• Apoptosis: A Review of Programmed Cell Death

  2007cited by this paper
• A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP

  2007cited by this paper
• Development of Peptidomimetics Targeting IAPs

  2006cited by this paper
• The apoptosome activates caspase-9 by dimerization.

  2006cited by this paper
• W323S variant of Xiap-Bir3 binds to SMAC but not caspase-9.

  2006cited by this paper
• Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine.

  2006cited by this paper
• Targeting XIAP for the treatment of malignancy

  2006cited by this paper
• XIAP inhibits caspase‐3 and ‐7 using two binding sites: evolutionarily conserved mechanism of IAPs

  2005cited by this paper
• Structure of the apoptotic protease-activating factor 1 bound to ADP

  2005cited by this paper
• Neuronal Apoptosis-inhibitory Protein Does Not Interact with Smac and Requires ATP to Bind Caspase-9*

  2004cited by this paper
• The protein structures that shape caspase activity, specificity, activation and inhibition.

  2004cited by this paper
• Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers?

  2004cited by this paper
• The inhibitors of apoptosis: there is more to life than Bcl2

  2003cited by this paper
• Prevention of Glucocorticoid‐Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin‐D28k

  2003cited by this paper
• Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac*

  2003cited by this paper
• Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia

  2003cited by this paper
• Mechanism of XIAP-mediated inhibition of caspase-9.

  2003cited by this paper
• A unified model for apical caspase activation.

  2003cited by this paper
• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

  2001influential reference
• Recruitment, activation and retention of caspases‐9 and ‐3 by Apaf‐1 apoptosome and associated XIAP complexes

  2001cited by this paper
• Recruitment

  2000cited by this paper
• Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

  1999cited by this paper
• Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

  1996cited by this paper

• Discovery of novel and highly potent XIAP-targeted peptide inhibitors using virtual screening

  2026cites this paper
• SMAC Mimetics for the Treatment of Lung Carcinoma: Present Development and Future Prospects.

  2024cites this paper
• A Cold-Inducible RNA Binding Protein Gene from Acanthopagrus schlegelii: Molecular Characterization, Expression, and Association with Apoptosis to Low-Temperature Stress

  2023cites this paper
• Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes.

  2021cites this paper
• SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme

  2021cites this paper
• Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

  2020cites this paper
• Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury.

  2018cites this paper
• 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

  2017cites this paper
• 10 H -3,6-Diazaphenothiazine induces g 2 /M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of a2780 ovarian carcinoma cells through the regulation of nF- κ B and (Birc6-XiaP) complexes

  2017cites this paper
• Overexpression of miR-489 enhances efficacy of 5-fluorouracil-based treatment in breast cancer stem cells by targeting XIAP

  2017cites this paper