Hepatocyte Nuclear Factor 4α enhances the Hepatocyte Nuclear Factor 1α‐mediated activation of transcription

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nucleic Acids Research

• Publication date

  2004-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/NAR/GKH581
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

  2004cited by this paper
• Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis

  2003cited by this paper
• Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding

  2003cited by this paper
• Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity.

  2003cited by this paper
• Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4*

  2003cited by this paper
• Sterol Regulatory Element-binding Protein-2 Interacts with Hepatocyte Nuclear Factor-4 to Enhance Sterol Isomerase Gene Expression in Hepatocytes*

  2003cited by this paper
• Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.

  2003cited by this paper
• Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

  2003influential reference
• Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.

  2002cited by this paper
• Hepatocyte Nuclear Factor-1 Recruits the Transcriptional CoActivator p 300 on the GLUT 2 Gene Promoter

  2002cited by this paper
• A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.

  2002cited by this paper
• Epstein-Barr Virus Nuclear Antigen 3C and Prothymosin Alpha Interact with the p300 Transcriptional Coactivator at the CH1 and CH3/HAT Domains and Cooperate in Regulation of Transcription and Histone Acetylation

  2002cited by this paper
• Experimental models of transcription factor-associated maturity-onset diabetes of the young.

  2002cited by this paper
• Mutations in hepatocyte nuclear factor 4α (HNF4α) gene associated with diabetes result in greater loss of HNF4α function in pancreatic β-cells than in nonpancreatic β-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells

  2002cited by this paper
• Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter.

  2002cited by this paper
• Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes*

  2002cited by this paper
• Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand*

  2002influential reference
• Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.

  2001cited by this paper
• Nuclear receptors and genetic disease

  2001cited by this paper
• Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator.

  2001cited by this paper
• Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

  2001cited by this paper
• Acetylation regulates transcription factor activity at multiple levels.

  2000cited by this paper
• Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene.

  2000cited by this paper
• Transcriptional Activation by Hepatocyte Nuclear Factor-1 Requires Synergism between Multiple Coactivator Proteins*

  2000influential reference
• Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.

  2000cited by this paper
• Activation of PPARgamma coactivator-1 through transcription factor docking.

  1999cited by this paper
• Regulation of α1-antitrypsin gene expression in human intestinal epithelial cell line Caco-2 by HNF-1α and HNF-4.

  1999cited by this paper
• Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter.

  1999cited by this paper
• Activation of PPARγ coactivator-1 through transcription factor docking

  1999cited by this paper
• Regulation of a 1 -antitrypsin gene expression in human intestinal epithelial cell line Caco-2 by HNF-1 a and HNF-4

  1999cited by this paper
• The activation function 2 domain of hepatic nuclear factor 4 is regulated by a short C-terminal proline-rich repressor domain.

  1998cited by this paper
• Regulation of the Human P450scc Gene by Steroidogenic Factor 1 Is Mediated by CBP/p300*

  1998cited by this paper
• Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.

  1998cited by this paper
• Regulation of a transcription factor network required for differentiation and metabolism.

  1998cited by this paper
• Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse

  1998cited by this paper
• Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome.

  1997cited by this paper
• Modulation of hepatic gene expression by hepatocyte nuclear factor 1.

  1997influential reference
• Functional Domains of the Nuclear Receptor Hepatocyte Nuclear Factor 4*

  1997cited by this paper
• Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome.

  1996cited by this paper
• Liver‐enriched transcription factors and hepatocyte differentiation

  1996influential reference
• Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

  1996cited by this paper
• Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

  1996cited by this paper
• Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

  1996cited by this paper
• Properties of initiator-associated transcription mediated by GAL4-VP16

  1993cited by this paper
• An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.

  1993influential reference
• Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis

  1993cited by this paper
• Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.

  1991cited by this paper
• cis-acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue-specific activators and extinguisher.

  1991cited by this paper
• Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

  1990cited by this paper
• To the Young

  1984cited by this paper

• Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma

  2025cites this paper
• Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes

  2024cites this paper
• Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathy

  2024cites this paper
• HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

  2024cites this paper
• Insight into continuous glucose monitoring: from medical basics to commercialized devices

  2023cites this paper
• HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks

  2022cites this paper
• Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity Onset Diabetes of the Young.

  2022cites this paper
• Principles of human and mouse nephron development

  2022cites this paper
• Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis

  2021cites this paper
• Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver

  2021cites this paper
• LINC00483 Has a Potential Tumor-Suppressor Role in Colorectal Cancer Through Multiple Molecular Axes

  2021cites this paper
• Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective.

  2021cites this paper
• A Review of Functional Characterization of Single Amino Acid Change Mutations in HNF Transcription Factors in MODY Pathogenesis

  2021cites this paper
• Signaling molecules orchestrating liver regenerative medicine

  2020cites this paper
• Heterozygous recurrent HNF4A variant p.Arg85Trp causes Fanconi renotubular syndrome 4 with maturity onset diabetes of the young, an autosomal dominant phenocopy of Fanconi Bickel syndrome with colobomas

  2020cites this paper
• Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

  2020cites this paper
• Baicalin down-regulating hepatitis B virus transcription depends on the liver-specific HNF4α-HNF1α axis.

  2020cites this paper
• Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

  2020cites this paper
• Hepatocyte nuclear factor 1 a suppresses steatosis-associated liver cancer by inhibiting PPAR g transcription

  2019cites this paper
• Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

  2019cites this paper
• Novel insights into genetics and clinics of the HNF1A-MODY

  2019cites this paper
• Hepatocyte nuclear factor 1a suppresses steatosis-associated liver cancer by inhibiting PPARg transcription

  2019cites this paper
• Novel mechanisms of glucolipotoxic pancreatic beta cell death

  2018cites this paper
• Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells.

  2018cites this paper
• Functional roles of Grainyhead-like transcription factors in renal development and disease

  2018cites this paper
• The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

  2017cites this paper
• Hepatocyte nuclear factor 1&agr; suppresses steatosis-associated liver cancer by inhibiting PPAR&ggr; transcription

  2017cites this paper
• The molecular functions of hepatocyte nuclear factors - In and beyond the liver.

  2017cites this paper
• Germinated Waxy Black Rice Ameliorates Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Rats.

  2017cites this paper
• Transcriptional mechanisms coordinating tight junction assembly during epithelial differentiation

  2017cites this paper
• Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma.

  2016cites this paper
• Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats

  2016cites this paper
• Genome‐wide association study in mice identifies loci affecting liver‐related phenotypes including Sel1l influencing serum bile acids

  2016cites this paper
• Transcriptional regulation of slc6a19 along the crypt-villus axis

  2016cites this paper
• The impact of serotonergic system dysfunction on the regulation of P4501A isoforms during liver insufficiency and consequences for thyroid hormone homeostasis.

  2016cites this paper
• Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

  2016cites this paper
• Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism

  2015cites this paper
• Reviews and Perspectives

  2014cites this paper
• Competitive regulation of human intestinal β-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1α and HNF-4α.

  2014cites this paper
• Enterocyte-specific Regulation of the Apical Nutrient Transporter SLC6A19 (B0AT1) by Transcriptional and Epigenetic Networks*

  2013cites this paper
• Enterocyte-specific Regulation of the Apical Nutrient Transporter SLC6A19 (B 0 AT1) by Transcriptional and

  2013cites this paper
• Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

  2012influential citation
• Anks4b, a Novel Target of HNF4α Protein, Interacts with GRP78 Protein and Regulates Endoplasmic Reticulum Stress-induced Apoptosis in Pancreatic β-Cells*

  2012cites this paper
• Exploring Molecular Mechanisms of Liver to Pancreatic Beta Cell Reprogramming

  2012cites this paper
• Low abundance plasma proteins in labour.

  2012cites this paper
• Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.

  2011cites this paper
• The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

  2011cites this paper
• Roles of hepatocyte nuclear factors (HNF) in the regulation of reproduction in teleosts.

  2010cites this paper
• A Computational Study of Protein-Protein and Protein-Ligand Interactions: A Focus on HNF4alpha and ATP Synthase.

  2010cites this paper
• Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α

  2010cites this paper
• Transcriptional control of hepatocyte differentiation.

  2010cites this paper
• Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2).

  2009cites this paper
• Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

  2009cites this paper
• Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

  2009cites this paper
• Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver

  2008cites this paper
• Identification of DNA regions and a set of transcriptional regulatory factors involved in transcriptional regulation of several human liver-enriched transcription factor genes

  2008cites this paper
• Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system.

  2008cites this paper
• Nuclear Receptors in the Control of Lipid Metabolism

  2008cites this paper
• Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4&agr;

  2007cites this paper
• Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression

  2006cites this paper
• hepatic MRP2 up-regulation during hepatitis C virus gene expression

  2006influential citation
• Mechanisms of mutual functional interactions between HNF-4α and HNF-1α revealed by mutations that cause maturity onset diabetes of the young

  2006cites this paper
• Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.

  2006cites this paper
• A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data

  2006cites this paper
• Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.

  2005cites this paper
• Nuclear Factor 1 Family Members Interact with Hepatocyte Nuclear Factor 1α to Synergistically Activate L-type Pyruvate Kinase Gene Transcription*

  2005cites this paper
• Hex stimulates the hepatocyte nuclear factor 1alpha-mediated activation of transcription.

  2005cites this paper
• Pathobiology of hepatobiliary neoplasms in children

  2004cites this paper
• Expression of the α7 Isoform of Hepatocyte Nuclear Factor (HNF) 4 Is Activated by HNF6/OC-2 and HNF1 and Repressed by HNF4α1 in the Liver*[boxs]

  2004cites this paper