Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-08-04

• Fields of study

  Medicine

• Identifiers
  DOI 10.1073/pnas.1303676111PMID 25092331PMCID PMC4143062
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling.

  2013cited by this paper
• Inflammation makes T cells sensitive.

  2013cited by this paper
• Cytokine-mediated programmed proliferation of virus-specific CD8(+) memory T cells.

  2013cited by this paper
• Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome.

  2012cited by this paper
• Role of the PD‐1 Pathway in the Immune Response

  2012cited by this paper
• rPSGL‐Ig for Improvement of Early Liver Allograft Function: A Double‐Blind, Placebo‐Controlled, Single‐Center Phase II Study †

  2011cited by this paper
• Effects of anti‐adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts 1,2

  2011cited by this paper
• T cell exhaustion

  2011influential reference
• Mycophenolic Acid‐Mediated Suppression of Human CD4+ T Cells: More Than Mere Guanine Nucleotide Deprivation

  2011cited by this paper
• Diagnosis and prevention of chronic kidney allograft loss.

  2011cited by this paper
• Animal Models of Chronic Allograft Injury: Contributions and Limitations to Understanding the Mechanism of Long-Term Graft Dysfunction

  2010cited by this paper
• Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

  2010cited by this paper
• Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

  2010cited by this paper
• Graft vascular disease: immune response meets the vessel wall.

  2009influential reference
• A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

  2008cited by this paper
• NFATc1 Regulates PD-1 Expression upon T Cell Activation1

  2008cited by this paper
• PD-1 and its ligands in tolerance and immunity.

  2008cited by this paper
• Importance of donor- and recipient-derived selectins in cardiac allograft rejection.

  2007cited by this paper
• Restoring function in exhausted CD8 T cells during chronic viral infection

  2006cited by this paper
• Preventing cardiac allograft vasculopathy: long-term beneficial effects of mycophenolate mofetil.

  2006cited by this paper
• Cardiac allograft vasculopathy: The achilles’ heel of long-term survival after cardiac transplantation

  2006cited by this paper
• Inverse correlation between IL‐7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation

  2005cited by this paper
• Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

  2004cited by this paper
• Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines.

  2004cited by this paper
• The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

  2003cited by this paper
• Intercellular cell adhesion molecule‐1 and selectin ligands in acute cardiac allograft rejection: a study on gene‐deficient mouse models

  2002influential reference
• The Role of E-Selectin, P-Selectin, and Very Late Activation Antigen-4 in T Lymphocyte Migration to Dermal Inflammation1

  2002cited by this paper
• Continued Antigen Stimulation Is Not Required During CD4+ T Cell Clonal Expansion1

  2002cited by this paper
• Chronic rejection.

  2001cited by this paper
• Acute rejection and cardiac graft vasculopathy in the absence of donor-derived ICAM-1 or P-selectin.

  2001cited by this paper
• Role of selectin-dependent adhesion in cardiac allograft rejection.

  1998cited by this paper
• Influence of initial antigen-independent events on acute allograft rejection: inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination.

  1998cited by this paper
• Adhesion molecule P-selectin and vascular cell adhesion molecule-1 in enhanced heart allograft arteriosclerosis in the rat.

  1997influential reference
• E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis.

  1997cited by this paper
• L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice.

  1997cited by this paper
• The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

  1996cited by this paper
• Chronic rejection.

  1994cited by this paper
• The Wiskott-Aldrich Syndrome Protein Regulates Nuclear Translocation of NFAT2 and NF-κB (RelA) Independently of Its Role in Filamentous Actin Polymerization and Actin Cytoskeletal Rearrangement1

  1988cited by this paper
• PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE: THE ROLE OF H‐2D, H‐2K, AND NON‐H-2 ANTIGENS IN REJECTION

  1973cited by this paper

• T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?

  2025cites this paper
• Clinical Manifestation, Mechanisms, and Potential Targets of Intervention for Chronic Rejection in Vascularized Composite Allotransplantation.

  2025cites this paper
• Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection

  2025cites this paper
• Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses

  2024cites this paper
• Exhaustion of T cells after renal transplantation

  2024cites this paper
• Identification of glycosyltransferase genes for diagnosis of T-cell mediated rejection and prediction of graft loss in kidney transplantation.

  2024cites this paper
• Immune Checkpoints in Solid Organ Transplantation

  2023cites this paper
• The CD226/TIGIT axis is involved in T cell hypo-responsiveness appearance in long-term kidney transplant recipients

  2022cites this paper
• Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival

  2022cites this paper
• An Emerging Role of TIM3 Expression on T Cells in Chronic Kidney Inflammation

  2022cites this paper
• Coupling of Co-expression Network Analysis and Machine Learning Validation Unearthed Potential Key Genes Involved in Rheumatoid Arthritis

  2021cites this paper
• miR‐21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy

  2021cites this paper
• CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?

  2021cites this paper
• Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition.

  2021cites this paper
• Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

  2021cites this paper
• Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer.

  2020cites this paper
• Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

  2019cites this paper
• Impact of infection on transplantation tolerance

  2019cites this paper
• Pronostic des récepteurs inhibiteurs associés a l'épuisement lymphocytaire en transplantation rénale incompatible

  2019cites this paper
• Resilience of T cell-intrinsic dysfunction in transplantation tolerance

  2019cites this paper
• T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO‐ versus HLA‐incompatible kidney transplant recipients

  2019cites this paper
• The pursuit of transplantation tolerance: new mechanistic insights

  2019cites this paper
• T-cell exhaustion correlates with improved outcomes in kidney transplant recipients.

  2019cites this paper
• Aging, Immunosenescence, and Transplantation Tolerance

  2019cites this paper
• Cellular and functional biomarkers of clinical transplant tolerance.

  2018cites this paper
• T cell exhaustion implications during transplantation.

  2018cites this paper
• T cell Allorecognition Pathways in Solid Organ Transplantation

  2018cites this paper
• Pigs expressing the human inhibitory ligand PD‐L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties

  2018cites this paper
• Resident memory T cells in the skin mediate durable immunity to melanoma

  2017cites this paper
• Immune Exhaustion and Transplantation

  2016cites this paper
• Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

  2016cites this paper
• HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs

  2016cites this paper
• Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4+ T cells to induce Type 2 helper T cell (Th2) bias at the maternal-fetal interface.

  2016cites this paper
• T Cell Cosignaling Molecules in Transplantation.

  2016cites this paper
• IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts

  2016cites this paper
• Endothelial activation, lymphangiogenesis, and humoral rejection of kidney transplants.

  2016cites this paper
• T-cell exhaustion in allograft rejection and tolerance

  2015cites this paper
• Cardiac Allograft Vasculopathy: A Donor or Recipient Induced Pathology?

  2015cites this paper
• Alma Mater Studiorum Università di Bologna Archivio istituzionale della ricerca

  year unknowncites this paper
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  year unknowncites this paper