Chondroprotective effect of alendronate in a rabbit model of osteoarthritis

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Orthopaedic Research

• Publication date

  2011-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jor.21394PMID 21462250
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Osteochondral angiogenesis and increased protease inhibitor expression in OA

  2010cited by this paper
• In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat.

  2010cited by this paper
• Positive Effect of Alendronate on Subchondral Bone Healing and Subsequent Cartilage Repair in a Rabbit Osteochondral Defect Model

  2009cited by this paper
• Radiographic Location of the Lateral Intercondylar Ridge

  2008cited by this paper
• The Effects of Bone Remodeling Inhibition by Alendronate on Three-Dimensional Microarchitecture of Subchondral Bone Tissues in Guinea Pig Primary Osteoarthrosis

  2008influential reference
• Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene

  2006cited by this paper
• Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.

  2006influential reference
• Influence of bisphosphonates on the production of pro-inflammatory cytokines by activated human articular chondrocytes.

  2005cited by this paper
• Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

  2005cited by this paper
• Osteoarthritis and bone: osteologic types of osteoarthritis of the hip

  2004cited by this paper
• The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model.

  2004cited by this paper
• Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis.

  2004cited by this paper
• Osteoarthritis: is it a disease of cartilage or of bone?

  2004cited by this paper
• Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee.

  2002influential reference
• Development and regulation of osteophyte formation during experimental osteoarthritis.

  2002cited by this paper
• The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor kappaB ligand system in cartilage.

  2001cited by this paper
• The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage.

  2001cited by this paper
• The role of the chondrocyte in osteoarthritis.

  2000cited by this paper
• Effects of a bisphosphonate on bone histomorphometry and dynamics in the canine cruciate deficiency model of osteoarthritis.

  1999cited by this paper
• Immunohistochemical analysis of type X‐collagen expression in osteoarthritis of the hip joint

  1999cited by this paper
• Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group.

  1998cited by this paper
• Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.

  1998cited by this paper
• Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

  1998cited by this paper
• Trabecular microstructure in the medial condyle of the proximal tibia of patients with knee osteoarthritis.

  1995cited by this paper
• A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months.

  1993cited by this paper
• Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy.

  1992cited by this paper
• The reliability of the mankin score for osteoarthritis

  1992cited by this paper
• The bisphosphonate alendronate (MK‐217) inhibits bone loss due to ovariectomy in rats

  1991cited by this paper
• Osteoarthritis and bone: osteologic types of osteoarthritis of the hip

  1989cited by this paper
• Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.

  1971cited by this paper

• Effect of Antiresorptive Therapy on Development of Posttraumatic Osteoarthritis after Intra-articular Distal Radius Fracture in Female Patients

  2025cites this paper
• Histological and Immunohistochemical Methods in Normal and Osteoarthritic Knee Cartilage of Rat and Rabbit Models: A Literature Review

  2025influential citation
• Investigation of the efficacy of intra-articular botulinum toxin type A application in the treatment of experimentally induced osteoarthritis in rats.

  2025cites this paper
• Potential role of different animal models for the evaluation of bioactive compounds

  2025cites this paper
• Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages

  2024cites this paper
• Proteomic and Morphological Analysis of Bone and Articular Cartilage Changes in Osteoarthritic Rabbits Supplemented with Edible Bird’s Nest (EBN)

  2024cites this paper
• Effects of alendronate on cartilage lesions and micro-architecture deterioration of subchondral bone in patellofemoral osteoarthritic ovariectomized rats with patella-baja

  2024cites this paper
• Alendronate treatment rescues the effects of compressive loading of TMJ in osteogenesis imperfecta mice

  2024cites this paper
• Differential effects of alendronate on chondrocytes, cartilage matrix and subchondral bone structure in surgically induced osteoarthritis in mice

  2024cites this paper
• NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis

  2023cites this paper
• Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis

  2023cites this paper
• Osteoarthritis: a narrative review of molecular approaches to disease management

  2023cites this paper
• Effects of acupotomy on the activity of osteoclasts and osteoblasts in the subchondral bone of rabbits with early and mid-stage knee osteoarthritis models

  2023cites this paper
• Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats

  2023cites this paper
• In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate

  2023cites this paper
• Is RANKL a potential molecular target in osteoarthritis?

  2023cites this paper
• Accumulation of zoledronic acid in rabbit intervertebral discs.

  2022cites this paper
• Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

  2022cites this paper
• Treatment of Surgically Induced Knee Osteoarthritis in Rats

  2022cites this paper
• Role of animal models in biomedical research: a review

  2022cites this paper
• Early inhibition of subchondral bone remodeling slows load‐induced posttraumatic osteoarthritis development in mice

  2021influential citation
• Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice.

  2021cites this paper
• Disease-Modifying Potential of Metformin and Alendronate in an Experimental Mouse Model of Osteoarthritis

  2021cites this paper
• Bisphosphonates as disease-modifying drugs in osteoarthritis preclinical studies: a systematic review from 2000 to 2020

  2021cites this paper
• Histomorphometric Quantitative Evaluation of Long-Term Risedronate Use in a Knee Osteoarthritis Rabbit Model

  2021cites this paper
• Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway

  2020cites this paper
• No Effect of Long-Term Risedronate Use on Cartilage and Subchondral Bone in an Experimental Rabbit Model of Osteoarthritis

  2020influential citation
• Transforming growth factor-β and skeletal homeostasis

  2020cites this paper
• Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

  2019cites this paper
• Local, intra-articular delivery of zoledronic acid as a disease-modifying therapeutic for post-traumatic osteoarthritis

  2019cites this paper
• Skeletal Changes Associated with Osteoarthritis

  2019cites this paper
• Protective Effect of Alendronate on Lumbar Facet Degeneration in Ovariectomized Rats

  2019cites this paper
• Editorial: Wnt Signaling Related to Subchondral Bone Density and Cartilage Degradation in Osteoarthritis

  2018cites this paper
• Transforming growth factor-β in stem cells and tissue homeostasis

  2018cites this paper
• Inducible nitric oxide synthase as a target for osteoarthritis treatment

  2018cites this paper
• Intra‐articular autologous uncultured adipose‐derived stromal cell transplantation inhibited the progression of cartilage degeneration

  2018cites this paper
• Subchondral bone fragility with meniscal tear accelerates and parathyroid hormone decelerates articular cartilage degeneration in rat osteoarthritis model

  2018cites this paper
• Subchondroplasty for treating bone marrow lesions in the knee – initial experience☆

  2017cites this paper
• Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.

  2017cites this paper
• Protective effect of zoledronic acid on articular cartilage and subchondral bone of rabbits with experimental knee osteoarthritis

  2017cites this paper
• Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model.

  2017cites this paper
• Subchondral bone sclerosis and cancellous bone loss following OA induction depend on the underlying bone phenotype.

  2017cites this paper
• Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials.

  2017cites this paper
• Wnt Signaling Related to Subchondral Bone Density and Cartilage Degradation in OA

  2017cites this paper
• Effects of bisphosphonates on osteogenesis and osteoclastogenesis signaling during the endochondral ossification of growing rats

  2017cites this paper
• Subcondroplastia no tratamento de lesões medulares ósseas no joelho - Experiência inicial

  2017cites this paper
• Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone

  2017cites this paper
• The potential role of sclerostin in the development of osteoarthritis

  2016cites this paper
• Using agents that suppress bone remodeling to treat or prevent joint disease: Quo vadis?

  2016cites this paper
• Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

  2016cites this paper
• The role of subchondral bone damage in post‐traumatic osteoarthritis

  2016cites this paper
• The determination of apoptosis rates on articular cartilages of ovariectomized rats with and without alendronate treatment.

  2016cites this paper
• Osthole Inhibits Proliferation and Induces Catabolism in Rat Chondrocytes and Cartilage Tissue

  2015cites this paper
• Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA

  2015cites this paper
• The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

  2015cites this paper
• Second Place: Alendronate reverses increases in MMP13 due to IL-1&bgr; stimulation in human chondrocytes in vitro

  2015cites this paper
• Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice

  2015influential citation
• The paracrine effect of adipose-derived stem cells inhibits osteoarthritis progression

  2015cites this paper
• Rose hip alleviates pain and disease progression in rats with monoiodoacetate induced osteoarthritis

  2014cites this paper
• Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits

  2014cites this paper
• An OA phenotype may obtain major benefit from bone-acting agents.

  2014cites this paper
• Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis

  2014cites this paper
• Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis

  2014cites this paper
• Chondroprotective effect of high‐dose zoledronic acid: An experimental study in a rabbit model of osteoarthritis

  2014cites this paper
• Emerging pathways and promising agents with possible disease modifying effect in osteoarthritis treatment.

  2014cites this paper
• Early intra-articular injection of alendronate reduces cartilage changes and subchondral bone loss in rat temporomandibular joints after ovariectomy.

  2014cites this paper
• Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies.

  2014cites this paper
• Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis.

  2014cites this paper
• Osteoarthritis: Molecular Mechanisms and Treatments

  2014cites this paper
• Перспективные направления терапии остеоартроза

  2014cites this paper
• Alendronate treatment for hip osteoarthritis: prospective randomized 2-year trial

  2013cites this paper
• The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

  2013cites this paper
• Protective effect of zoledronic acid on corticosteroid-induced chondrocyte apoptosis in rat articular cartilage.

  2013cites this paper
• No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis

  2013cites this paper
• Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.

  2013cites this paper
• [Evaluation of the efficacy and tolerance of ibandronic acid in patients with osteoarthrosis in the knee joints concurrent with osteoporosis: a pilot study].

  2013cites this paper
• Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone/cartilage turnover, and joint discomfort.

  2013cites this paper
• Downregulation of the Inflammatory Response by CORM-3 Results in Protective Effects in a Model of Postmenopausal Arthritis

  2012cites this paper
• Osteoarthritis, a disease bridging development and regeneration.

  2012cites this paper
• MEDICAL AND NUTRITIONAL THERAPIES FOR OA

  2012cites this paper
• Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis

  2012cites this paper
• Impact of treatments for osteoporosis on osteoarthritis progression

  2012cites this paper
• Domestic animal models for biomedical research.

  2012cites this paper
• A proposed model of naturally occurring osteoarthritis in the domestic rabbit

  2011cites this paper
• Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

  2011cites this paper