Multiple Ligands Targeting Cholinesterases and β‐Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Archiv der Pharmazie

• Publication date

  2015-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/ardp.201500117PMID 26032855
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids

  2015cited by this paper
• Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.

  2015cited by this paper
• Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.

  2015cited by this paper
• Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

  2014cited by this paper
• Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

  2014cited by this paper
• Multifunctional compounds: smart molecules for multifactorial diseases.

  2014cited by this paper
• Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.

  2014cited by this paper
• The prevalence of dementia in urban and rural areas of China

  2014cited by this paper
• Clinical trials and late‐stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

  2014cited by this paper
• Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

  2014cited by this paper
• Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.

  2014cited by this paper
• Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.

  2013cited by this paper
• Structure-Based Search for New Inhibitors of Cholinesterases

  2013cited by this paper
• The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti‐Alzheimer Multitarget Profile of Dimebon

  2013cited by this paper
• Multi-target compounds acting in the central nervous system designed from natural products.

  2013cited by this paper
• Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

  2013cited by this paper
• Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

  2013cited by this paper
• Design, Synthesis and Evaluation of Novel 2‐(Aminoalkyl)‐isoindoline‐1,3‐dione Derivatives as Dual‐Binding Site Acetylcholinesterase Inhibitors

  2012cited by this paper
• Treatment strategies targeting amyloid β-protein.

  2012cited by this paper
• Alzheimer disease in 2020.

  2012cited by this paper
• Alzheimer mechanisms and therapeutic strategies.

  2012cited by this paper
• Selective catalytic monoreduction of phthalimides and imidazolidine-2,4-diones.

  2011cited by this paper
• Hybrid-based multi-target ligands for the treatment of Alzheimer's disease.

  2011cited by this paper
• Membrane and surface interactions of Alzheimer’s Aβ peptide – insights into the mechanism of cytotoxicity

  2011cited by this paper
• Alzheimer's disease.

  2010cited by this paper
• The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics

  2009cited by this paper
• Multi-target-directed ligands to combat neurodegenerative diseases.

  2008cited by this paper
• Formation of 4,5,6,7-tetrahydroisoindoles by palladium-catalyzed hydride reduction.

  2007cited by this paper
• Synthetic studies on the CDEF ring system of lactonamycin

  2006cited by this paper
• Sulfonamide Ligands Attained Through Opening of Saccharin Derivatives

  2006cited by this paper
• Designed multiple ligands. An emerging drug discovery paradigm.

  2005cited by this paper
• Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.

  2005cited by this paper
• The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.

  2004cited by this paper
• A concise stereospecific synthesis of repinotan (BAY×3702) ☆

  2003cited by this paper
• High throughput artificial membrane permeability assay for blood-brain barrier.

  2003cited by this paper
• Making connections: cholinesterase-domain proteins in the CNS

  2003cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.

  2001cited by this paper
• A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation.

  2001cited by this paper
• Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth

  2001cited by this paper
• The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease

  2001cited by this paper
• Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.

  1999cited by this paper
• Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

  1996cited by this paper
• Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.

  1995cited by this paper
• Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution

  1993cited by this paper
• Cholinesterases regulate neurite growth of chick nerve cells in vitro by means of a non-enzymatic mechanism

  1993cited by this paper
• Alzheimer's disease: the amyloid cascade hypothesis.

  1992cited by this paper
• The molecular pathology of Alzheimer's disease.

  1991cited by this paper
• Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

  1991cited by this paper
• E2020 - THE PHARMACOLOGY OF A PIPERIDINE CHOLINESTERASE INHIBITOR

  1991cited by this paper
• Amyloid deposition as the central event in the aetiology of Alzheimer's disease.

  1991cited by this paper
• Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.

  1976cited by this paper
• Selective loss of central cholinergic neurons in Alzheimer's disease.

  1976cited by this paper
• A new and rapid colorimetric determination of acetylcholinesterase activity.

  1961cited by this paper

• Acetylcholinesterase as a Multifunctional Target in Amyloid-Driven Neurodegeneration: From Dual-Site Inhibitors to Anti-Agregation Strategies

  2025cites this paper
• A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)

  2022cites this paper
• 2-(3-Hydroxybenzyl)benzo[d]isothiazol-3(2H)-one Mannich base derivatives as potential multifunctional anti-Alzheimer’s agents

  2021cites this paper
• Critical evaluation of current Alzheimer's drug discovery (2018-19) & futuristic Alzheimer drug model approach.

  2019cites this paper
• Donepezil Derivatives Targeting Amyloid-β cascade in Alzheimer's Disease.

  2019cites this paper
• Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands.

  2019cites this paper
• Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.

  2018cites this paper
• Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

  2018cites this paper
• Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.

  2018cites this paper
• Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.

  2017cites this paper
• Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

  2017cites this paper
• Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

  2016cites this paper