G‐protein‐coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß‐d‐glucuronide‐induced cholestasis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Hepatology

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.26752PMID 24115158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K

  2012cited by this paper
• Localization status of hepatocellular transporters in cholestasis.

  2012cited by this paper
• PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity.

  2012cited by this paper
• Sequential Activation of Classic PKC and Estrogen Receptor α Is Involved in Estradiol 17ß-D-Glucuronide-Induced Cholestasis

  2012cited by this paper
• Prevention of estradiol 17β-d-glucuronide–induced canalicular transporter internalization by hormonal modulation of cAMP in rat hepatocytes

  2011cited by this paper
• Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation*

  2011cited by this paper
• Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes

  2011cited by this paper
• Activity-dependent modulation of endocytosis by calmodulin at a large central synapse

  2011cited by this paper
• 1000 ROLE OF CALCIUM-CALMODULIN PATHWAY IN ESTRADIOL-17β-GLUCURONIDE INDUCED IMPAIRMENT OF CANALICULAR SECRETION IN ISOLATED RAT HEPATOCYTE COUPLETS

  2010cited by this paper
• Phosphoinositide 3‐kinase/protein kinase B signaling pathway is involved in estradiol 17β‐d‐glucuronide–induced cholestasis: Complementarity with classical protein kinase c

  2010cited by this paper
• D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor Recycling*

  2009cited by this paper
• New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation.

  2009influential reference
• Hepatocellular transport in acquired cholestasis: new insights into functional, regulatory and therapeutic aspects.

  2008cited by this paper
• Ca2+‐dependent protein kinase C isoforms are critical to estradiol 17β‐D‐glucuronide–induced cholestasis in the rat

  2008cited by this paper
• Physiology of bile secretion.

  2008cited by this paper
• G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.

  2007cited by this paper
• Protein Kinase A-dependent Translocation of Hsp90α Impairs Endothelial Nitric-oxide Synthase Activity in High Glucose and Diabetes*

  2007cited by this paper
• Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.

  2007cited by this paper
• 17β-Estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells

  2006cited by this paper
• 17 beta-estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells.

  2006cited by this paper
• Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation*

  2006cited by this paper
• Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity.

  2005cited by this paper
• Localized effects of cAMP mediated by distinct routes of protein kinase A.

  2004cited by this paper
• siRNA Selection Server: an automated siRNA oligonucleotide prediction server

  2004cited by this paper
• Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats.

  2003cited by this paper
• Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat

  2003cited by this paper
• Mammalian ABC transporters in health and disease.

  2002cited by this paper
• Rap1 signalling: adhering to new models

  2001cited by this paper
• Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

  2000cited by this paper
• Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide.

  2000cited by this paper
• Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C

  2000cited by this paper
• Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: Role of the cytoskeleton

  2000cited by this paper
• Molecular regulation of hepatocellular transport systems in cholestasis.

  1999cited by this paper
• Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets.

  1998cited by this paper
• Estrogens cause rapid activation of IP3-PKC-alpha signal transduction pathway in HEPG2 cells.

  1998cited by this paper
• Cholestatic properties and hepatic transport of steroid glucuronides.

  1997cited by this paper
• Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.

  1997cited by this paper
• Transport characteristics of three fluorescent conjugated bile acid analogs in isolated rat hepatocytes and couplets

  1995cited by this paper
• Purification of hepatocyte couplets by centrifugal elutriation

  1991cited by this paper
• Recurrent jaundice in pregnancy. IV. Quantitative determination of urinary and biliary estrogens, including studies in pruritus gravidarum.

  1974cited by this paper
• Recurrent Jaundice in Pregnancy. IV. Quantitative Determination of Urinary and Biliary Estrogens, Including Studies in Pruritus Gravidarum1

  1974cited by this paper
• Recurrent jaundice of pregnancy: A clinical study of twenty-two cases

  1967cited by this paper

• Unveiling estrogen’s role: a comprehensive review of its impact on skin health and disease

  2026cites this paper
• GPR30-driven fatty acid oxidation targeted by ginsenoside Rd maintains mitochondrial redox homeostasis to restore vascular barrier in diabetic retinopathy

  2025cites this paper
• Efficacy and mechanism of inhibition of the GPR30-PI3K pathway by 4-phenylbutyric acid in the treatment of intrahepatic cholestasis of pregnancy

  2025influential citation
• New finding based on Comparative Toxicogenomics Database: Hepatic YY1 mediates drug-induced liver injury.

  2024cites this paper
• NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17ß-d-GLUCURONIDE-INDUCED CHOLESTASIS.

  2024cites this paper
• G protein–coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling

  2024cites this paper
• Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1

  2024cites this paper
• GPR30 Alleviates Pressure Overload-Induced Myocardial Hypertrophy in Ovariectomized Mice by Regulating Autophagy

  2023cites this paper
• G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications

  2023cites this paper
• The methylimidazolium ionic liquid M8OI is a substrate for OCT1 and p-glycoprotein-1 in rat.

  2023cites this paper
• Membrane estrogen receptor and follicle-stimulating hormone receptor.

  2023cites this paper
• Roles of BSEP protein in estrogen-induced intrahepatic cholestasis of pregnancy

  2023cites this paper
• The G protein-coupled oestrogen receptor GPER in health and disease: an update

  2023cites this paper
• Phytoestrogens, novel dietary supplements for breast cancer.

  2023cites this paper
• Identification of molecular initiating events and key events leading to endocrine disrupting effects of PFOA: Integrated molecular dynamic, transcriptomic, and proteomic analyses.

  2022cites this paper
• Estradiol (E2) Improves Glucose-Stimulated Insulin Secretion and Stabilizes GDM Progression in a Prediabetic Mouse Model

  2022cites this paper
• Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice.

  2021cites this paper
• GPER-Induced ERK Signaling Decreases Cell Viability of Hepatocellular Carcinoma

  2021cites this paper
• Role of G Protein-Coupled Estrogen Receptor in Digestive System Carcinomas: A Minireview

  2021cites this paper
• Role of G Protein-Coupled Estrogen Receptor in Digestive System Carcinomas: A Minireview

  2021cites this paper
• The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30

  2021cites this paper
• Activation of Estrogen Receptor G Protein–Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice

  2020cites this paper
• Bisphenols and Leydig Cell Development and Function

  2020cites this paper
• Genetic contribution of ABCC2 to Dubin‐Johnson syndrome and inherited cholestatic disorders

  2020cites this paper
• A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice

  2020cites this paper
• Role of ERK1/2 in TNFα-induced internalization of Abcc2 in rat hepatocyte couplets.

  2019cites this paper
• Bioinformatics‑based identification of key pathways and candidate genes for estrogen‑induced intrahepatic cholestasis using DNA microarray analysis.

  2019cites this paper
• Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis.

  2019cites this paper
• Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats

  2019cites this paper
• The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism

  2019cites this paper
• Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER

  2019influential citation
• GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.

  2019cites this paper
• Inside the Endometrial Cell Signaling Subway: Mind the Gap(s)

  2018cites this paper
• Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver.

  2018cites this paper
• Reconsidering the roles of endogenous estrogens and xenoestrogens: the membrane estradiol receptor G protein-coupled receptor 30 (GPR30) mediates the effects of various estrogens

  2018cites this paper
• The Role of GPER Signaling in Carcinogenesis: A Focus on Prostate Cancer

  2018cites this paper
• Molecular pathways of oestrogen receptors and β‐adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value

  2017cites this paper
• Activation of insulin-like growth factor 1 receptor participates downstream of GPR30 in estradiol-17β-d-glucuronide-induced cholestasis in rats

  2017cites this paper
• Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

  2017cites this paper
• Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse

  2017cites this paper
• Estrogen lowers triglyceride via regulating hepatic APOA5 expression

  2017cites this paper
• UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats.

  2016cites this paper
• Biología celular del proceso de internalización endocítica de transportadores hepatocelulares canaliculares en colestasis por estrógenos

  2016cites this paper
• EGFR participates downstream of ERα in estradiol-17β-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets

  2016cites this paper
• Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats

  2016cites this paper
• G protein‐coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice

  2016cites this paper
• Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF‐κB signals

  2016cites this paper
• A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release

  2015cites this paper
• Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells

  2015cites this paper
• Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells

  2015cites this paper
• International Union of Basic and Clinical Pharmacology. XCVII. G Protein–Coupled Estrogen Receptor and Its Pharmacologic Modulators

  2015cites this paper
• GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus.

  2014cites this paper
• G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction

  2014cites this paper
• Estrogen biology: new insights into GPER function and clinical opportunities.

  2014cites this paper
• Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis

  2014cites this paper