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Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature.

C. Cho,Lihai Yu,T. Nsiama,Alisha N. Kadam,Arun Raturi,Sourabh Shukla,Giulio A. Amadei,N. Steinmetz,L. Luyt,J. Lewis

Published 2017 in Nanoscale

ABSTRACT

Angiogenesis is a dynamic process fundamental to the development of solid tumors. Epidermal growth factor-like domain 7 (EGFL7) is a protein whose expression is restricted to endothelial cells undergoing active remodeling that has emerged as a key mediator of this process. EGFL7 expression is associated with poor outcome in several cancers, making it a promising target for imaging or therapeutic strategies. Here, EGFL7 is explored as a molecular target for active neovascularization. Using a combinatorial peptide screening approach, we describe the discovery and characterization of a novel high affinity EGFL7-binding peptide, E7p72, that specifically targets human endothelial cells. Viral nanoparticles decorated with E7p72 peptides specifically target tumor-associated neovasculature with high specificity as assessed by intravital imaging. This work highlights the value of EGFL7 as a target for angiogenic vessels and opens the door for novel targeted therapeutic approaches.

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