Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of General Virology

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1099/vir.0.2008/004051-0PMID 18931065PMCID PMC2876975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer.

  2007cited by this paper
• Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus.

  2005cited by this paper
• The Cotton Rat (Sigmodon hispidus) Is a Permissive Small Animal Model of Human Metapneumovirus Infection, Pathogenesis, and Protective Immunity

  2005cited by this paper
• Impact of human metapneumovirus in childhood: Comparison with respiratory syncytial virus and influenza viruses

  2005cited by this paper
• Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children.

  2004cited by this paper
• Human Metapneumovirus as a Major Cause of Human Respiratory Tract Disease

  2004cited by this paper
• Biochemical characterization of the respiratory syncytial virus P-P and P-N protein complexes and localization of the P protein oligomerization domain.

  2004influential reference
• A 1-Year Experience with Human Metapneumovirus in Children Aged <5 Years

  2004cited by this paper
• Human Metapneumovirus Infection among Children Hospitalized with Acute Respiratory Illness

  2004cited by this paper
• An improved cyan fluorescent protein variant useful for FRET

  2004cited by this paper
• Life-Threatening Human Metapneumovirus Pneumonia Requiring Extracorporeal Membrane Oxygenation in a Preterm Infant

  2004cited by this paper
• Recovery of Human Metapneumovirus Genetic Lineages A and B from Cloned cDNA

  2004cited by this paper
• Domains of Human Respiratory Syncytial Virus P Protein Essential for Homodimerization and for Binding to N and NS1 Protein

  2004cited by this paper
• Profilin is required for viral morphogenesis, syncytium formation, and cell-specific stress fiber induction by respiratory syncytial virus

  2003cited by this paper
• Investigations into the amino-terminal domain of the respiratory syncytial virus nucleocapsid protein reveal elements important for nucleocapsid formation and interaction with the phosphoprotein.

  2003cited by this paper
• Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein.

  2003influential reference
• Human metapneumovirus infections in young and elderly adults.

  2003cited by this paper
• Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients.

  2003cited by this paper
• Identification of Temperature-Sensitive Mutations in the Phosphoprotein of Respiratory Syncytial Virus That Are Likely Involved in Its Interaction with the Nucleoprotein

  2002cited by this paper
• Significant differences in nucleocapsid morphology within the Paramyxoviridae.

  2002cited by this paper
• A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

  2002cited by this paper
• Analysis of the genomic sequence of a human metapneumovirus.

  2002influential reference
• Characterization of monoclonal antibodies raised against recombinant respiratory syncytial virus nucleocapsid (N) protein: identification of a region in the carboxy terminus of N involved in the interaction with P protein.

  2001cited by this paper
• A newly discovered human pneumovirus isolated from young children with respiratory tract disease

  2001cited by this paper
• Profilin Is Required for Optimal Actin-Dependent Transcription of Respiratory Syncytial Virus Genome RNA

  2000cited by this paper
• Identification of regions of bovine respiratory syncytial virus N protein required for binding to P protein and self-assembly.

  1998cited by this paper
• Characterization of the interaction of the human respiratory syncytial virus phosphoprotein and nucleocapsid protein using the two-hybrid system.

  1998cited by this paper
• Interactions between cellular actin and human respiratory syncytial virus (HRSV).

  1998cited by this paper
• Role of cellular actin in the gene expression and morphogenesis of human respiratory syncytial virus.

  1998cited by this paper
• Orthomyxoviridae: The Viruses and Their Replication.

  1996cited by this paper
• Identification of protein regions involved in the interaction of human respiratory syncytial virus phosphoprotein and nucleoprotein: significance for nucleocapsid assembly and formation of cytoplasmic inclusions

  1996influential reference
• Characterisation of the interaction between the nucleoprotein and phosphoprotein of pneumonia virus of mice.

  1995cited by this paper
• Paramyxovirus phosphoproteins form homotrimers as determined by an epitope dilution assay, via predicted coiled coils.

  1995cited by this paper
• In vivo interaction of rabies virus phosphoprotein (P) and nucleoprotein (N): existence of two N-binding sites on P protein.

  1994cited by this paper
• Cytoplasmic inclusions of respiratory syncytial virus-infected cells: formation of inclusion bodies in transfected cells that coexpress the nucleoprotein, the phosphoprotein, and the 22K protein.

  1993influential reference
• Cloning and sequencing of the matrix protein (M) gene of turkey rhinotracheitis virus reveal a gene order different from that of respiratory syncytial virus

  1992cited by this paper
• Assembly of nucleocapsidlike structures in animal cells infected with a vaccinia virus recombinant encoding the measles virus nucleoprotein

  1991cited by this paper
• Measles virus phosphoprotein retains the nucleocapsid protein in the cytoplasm.

  1991cited by this paper
• Separate domains of Sendai virus P protein are required for binding to viral nucleocapsids.

  1990cited by this paper
• Carboxyl-terminal region of Sendai virus P protein is required for binding to viral nucleocapsids.

  1988cited by this paper
• Morphogenesis of Respiratory Syncytial Virus in a Green Monkey Kidney Cell Line (Vero)

  1970cited by this paper
• Development of measles virus in vitro.

  1969cited by this paper
• Morphogenesis of Type 2 Parainfluenza Virus Examined by Light and Electron Microscopy

  1967cited by this paper
• An electron microscopic study of moderate and virulent virus-cell interactions of the parainfluenza virus SV5.

  1966cited by this paper

• Human metapneumovirus: understanding the molecular mechanisms and pathology of infection

  2025cites this paper
• In silico drug repurposing targeting fusion and nucleoprotein of human metapneumovirus: A step toward pandemic preparedness

  2025cites this paper
• Next-generation multi-epitope subunit vaccine design: A computational approach utilizing two stable proteins to combat Human Metapneumovirus (HMPV)

  2025cites this paper
• hMPV Outbreaks: Worldwide Implications of a Re-Emerging Respiratory Pathogen

  2025cites this paper
• Human Metapneumovirus: A Critical Review of Its Impact on the Immune System and Clinical Implications

  2025cites this paper
• Structure and assembly of Borna disease virus 1 nucleoprotein–RNA complexes

  2025cites this paper
• A Review On Pathology Of Human Metapneumovirus (HMPV)

  2025cites this paper
• A Re-emerging Respiratory Virus: Human Metapneumovirus (hMPV)

  2025cites this paper
• Global surge of human metapneumovirus (hMPV) and its interactions with microbiome to disease severity.

  2025cites this paper
• Human metapneumovirus SH protein promotes JAK1 degradation to impair host IL-6 signaling

  2024cites this paper
• Human metapneumovirus SH protein promotes JAK1 degradation to impair host IL-6 signaling

  2024cites this paper
• Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice

  2024cites this paper
• Actin cytoskeleton dynamics affect replication of human Metapneumovirus

  2024cites this paper
• Molten globule driven and self-downmodulated phase separation of a viral factory scaffold

  2023cites this paper
• Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase Complex

  2023influential citation
• Nyamanini Virus Nucleoprotein and Phosphoprotein Organize Viral Inclusion Bodies That Associate with Host Biomolecular Condensates in the Nucleus

  2023cites this paper
• Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions

  2023cites this paper
• The intricacies of Ebola NP0VP35 formation of inclusion body-like structures and their disruption reducing viral infection.

  2023cites this paper
• Spatial resolution of virus replication: RSV and cytoplasmic inclusion bodies.

  2023cites this paper
• Ebola virus inclusion bodies are liquid organelles whose formation is facilitated by nucleoprotein oligomerization

  2023cites this paper
• Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies

  2022cites this paper
• Liquid Phase Partitioning in Virus Replication: Observations and Opportunities.

  2022cites this paper
• Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus

  2021cites this paper
• Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus

  2021cites this paper
• Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals

  2021cites this paper
• Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation.

  2021cites this paper
• Host Components That Modulate the Disease Caused by hMPV

  2021cites this paper
• Human metapneumovirus P protein independently drives phase separation and recruits N protein to liquid-like inclusion bodies

  2021cites this paper
• Induction of Protective Immunity by a Single Low Dose of a Master Cell Bank cGMP-rBCG-P Vaccine Against the Human Metapneumovirus in Mice

  2021cites this paper
• Pneumoviral Phosphoprotein, a Multidomain Adaptor-Like Protein of Apparent Low Structural Complexity and High Conformational Versatility

  2021cites this paper
• The mechanism underlying the organization of Borna disease virus inclusion bodies is unique among mononegaviruses

  2021cites this paper
• Negri bodies and other virus membrane-less replication compartments

  2020cites this paper
• Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly

  2020cites this paper
• Ebola Virus Inclusion Body Formation and RNA Synthesis Are Controlled by a Novel Domain of Nucleoprotein Interacting with VP35

  2020influential citation
• Innate Immune Components That Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections

  2020cites this paper
• Structure, dynamics and phase separation of measles virus RNA replication machinery.

  2020cites this paper
• Respiratory Syncytial Virus and Human Metapneumovirus Infections in Three-Dimensional Human Airway Tissues Expose an Interesting Dichotomy in Viral Replication, Spread, and Inhibition by Neutralizing Antibodies

  2020cites this paper
• Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

  2020cites this paper
• Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates

  2020cites this paper
• To assemble or not to assemble: The changing rules of pneumovirus transmission.

  2019cites this paper
• Structure and Function of Negri Bodies.

  2019cites this paper
• Особенности течения метапневмовирусной инфекции у взрослых

  2019cites this paper
• Features of the Course of Metapneumoviral Infection in Adults

  2019cites this paper
• Nipah virus induces two inclusion body populations: Identification of novel inclusions at the plasma membrane

  2019cites this paper
• Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles

  2019influential citation
• Physical Virology: Virus Structure and Mechanics

  2019cites this paper
• Human metapneumovirus - what we know now

  2018cites this paper
• Recombinant BCG Vaccines Reduce Pneumovirus-Caused Airway Pathology by Inducing Protective Humoral Immunity

  2018cites this paper
• Développement de vaccins sous-unitaires contre le métapneumovirus humain

  2018cites this paper
• Étude de l'infection par le métapneumovirus humain : facteurs de virulence et développement de vaccins vivants atténués

  2018cites this paper
• Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient Genome Replication and Transcription

  2017influential citation
• Negri bodies are viral factories with properties of liquid organelles

  2017cites this paper
• Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering

  2017cites this paper
• LATE EVENTS OF HUMAN METAPNEUMOVIRUS INFECTION: INSIGHTS INTO VIRAL SPREAD WITHIN THE RESPIRATORY EPITHELIUM

  2016influential citation
• Nucleocapsid proteins: roles beyond viral RNA packaging

  2016cites this paper
• Modulation of Host Immunity by the Human Metapneumovirus

  2016cites this paper
• Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated α-Tubulin Enhances Viral Replication

  2016cites this paper
• Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs*

  2016cites this paper
• Human metapneumovirus small hydrophobic (SH) protein downregulates type I IFN pathway signaling by affecting STAT1 expression and phosphorylation.

  2016cites this paper
• Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread

  2016cites this paper
• Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design.

  2015cites this paper
• Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

  2014cites this paper
• An Amino Acid of Human Parainfluenza Virus Type 3 Nucleoprotein Is Critical for Template Function and Cytoplasmic Inclusion Body Formation

  2013cites this paper
• CRITICAL EVENTS IN HUMAN METAPNEUMOVIRUS INFECTION: FROM ENTRY TO EGRESS

  2013influential citation
• Inclusion Body Formation Template Function and Cytoplasmic Virus Type 3 Nucleoprotein Is Critical for An Amino Acid of Human Parainfluenza

  2013cites this paper
• Analysis of Sequence Diversity of Human Metapneumovirus Collected from Young Children with Acute Respiratory Tract Infections in South India

  2013cites this paper
• Evidence for the interaction of the human metapneumovirus G and F proteins during virus-like particle formation

  2013cites this paper
• Solution and Crystallographic Structures of the Central Region of the Phosphoprotein from Human Metapneumovirus

  2013cites this paper
• Human Metapneumovirus Antagonism of Innate Immune Responses

  2012cites this paper
• p38 and OGT Sequestration into Viral Inclusion Bodies in Cells Infected with Human Respiratory Syncytial Virus Suppresses MK2 Activities and Stress Granule Assembly

  2012cites this paper
• Respiratory Syncytial Virus and Human Metapneumovirus

  2011cites this paper