Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized 1H MRS study

No abstract is available for this paper.

• Publication year

  2009

• Venue

  NMR in Biomedicine

• Publication date

  2009-08-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/nbm.1385PMID 19338025PMCID PMC2732191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute Increase of the Glutamate–Glutamine Cycling in Discrete Brain Areas after Administration of a Single Dose of Amphetamine

  2008cited by this paper
• Nitric Oxide Signaling in the Medial Prefrontal Cortex is Involved in the Biochemical and Behavioral Effects of Phencyclidine

  2008cited by this paper
• Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania.

  2008cited by this paper
• Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology.

  2008cited by this paper
• Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo1H NMR spectroscopy

  2007cited by this paper
• Isoflurane Strongly Affects the Diffusion of Intracellular Metabolites, as Shown by 1H Nuclear Magnetic Resonance Spectroscopy of the Monkey Brain

  2007cited by this paper
• NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons

  2007cited by this paper
• Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex

  2006cited by this paper
• First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients

  2006cited by this paper
• Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis

  2006cited by this paper
• Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations.

  2006cited by this paper
• Glial–Neuronal Interactions are Impaired in the Schizophrenia Model of Repeated MK801 Exposure

  2006cited by this paper
• Selective interaction of nitric oxide synthase inhibition with phencyclidine: behavioural and NMDA receptor binding studies in the rat.

  2005cited by this paper
• Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801

  2005cited by this paper
• Impaired neuronal glucose uptake in pathogenesis of schizophrenia - can GLUT 1 and GLUT 3 deficits explain imaging, post-mortem and pharmacological findings?

  2005cited by this paper
• Functional magnetic resonance imaging reveals similar brain activity changes in two different animal models of schizophrenia

  2005cited by this paper
• Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study.

  2005cited by this paper
• Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists

  2004cited by this paper
• The GABA-glutamate connection in schizophrenia: which is the proximate cause?

  2004cited by this paper
• The NMDA Receptor Hypofunction Model of Psychosis

  2003cited by this paper
• Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

  2003cited by this paper
• Activation of Glutamate Neurotransmission in the Prefrontal Cortex Sustains the Motoric and Dopaminergic Effects of Phencyclidine

  2003cited by this paper
• NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

  2003cited by this paper
• Animal behavior models of the mechanisms underlying antipsychotic atypicality.

  2003cited by this paper
• Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers.

  2002cited by this paper
• Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia.

  2002cited by this paper
• Metabolic changes in quinolinic acid‐lesioned rat striatum detected non‐invasively by in vivo 1H NMR spectroscopy

  2001cited by this paper
• Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex.

  2001cited by this paper
• Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence.

  2001cited by this paper
• Field mapping without reference scan using asymmetric echo‐planar techniques

  2000cited by this paper
• Effects of Ketamine, MK-801, and Amphetamine on Regional Brain 2-Deoxyglucose Uptake in Freely Moving Mice

  2000cited by this paper
• NMDA receptor hypofunction model of schizophrenia.

  1999cited by this paper
• The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

  1999cited by this paper
• In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time

  1999cited by this paper
• Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain.

  1999cited by this paper
• Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence

  1998cited by this paper
• Prefrontal cortex glucose metabolism and startle eyeblink modification abnormalities in unmedicated schizophrenia patients.

  1998cited by this paper
• Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.

  1998cited by this paper
• Mitochondrial Activity in the Mapping of Functional Brain Changes in Schizophrenia

  1998cited by this paper
• Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics.

  1997cited by this paper
• Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

  1997cited by this paper
• Regional cerebral blood flow and negative/positive symptoms in 24 drug-naive schizophrenics.

  1997cited by this paper
• Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy.

  1997cited by this paper
• High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients.

  1995cited by this paper
• Cerebral metabolic changes induced by MK-801: a 1D (phosphorus and proton) and 2D (proton) in vivo NMR spectroscopy study.

  1994cited by this paper
• Delayed regional metabolic actions of phencyclidine.

  1993cited by this paper
• Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats.

  1991cited by this paper
• Regional alterations in brain amino acids after administration of the receptor antagonists MK-801 and CGP 39551 in rats

  1991cited by this paper
• Recent advances in the phencyclidine model of schizophrenia.

  1991cited by this paper
• Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs.

  1989cited by this paper
• PCP‐induced alterations in cerebral glucose utilization in rat brain: Blockade by metaphit, a PCP‐receptor‐acylating agent

  1987cited by this paper
• Alterations in local cerebral glucose utilization induced by phencyclidine.

  1987cited by this paper

• Metabolic Mechanisms in Electroconvulsive Therapy for Schizophrenia: Role, Potential and Future Directions.

  2026cites this paper
• Progress in The Research of Lactate Metabolism Disruption And Astrocyte‐Neuron Lactate Shuttle Impairment in Schizophrenia: A Comprehensive Review

  2024cites this paper
• Ketamine administration in idiopathic epileptic and healthy control dogs: Can we detect differences in brain metabolite response with spectroscopy?

  2023cites this paper
• The association between N-methyl-d-aspartate receptor availability and glutamate levels: A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls

  2022cites this paper
• Functional Connectome in Bipolar Disorder

  2021cites this paper
• fMRI Neurofeedback as Treatment for Depression

  2021cites this paper
• Electrophysiological Biomarkers for Mood Disorders

  2021cites this paper
• Functional Near-Infrared Spectroscopy Studies in Mood Disorders

  2021cites this paper
• Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders

  2021cites this paper
• Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders

  2021cites this paper
• Effects of Lithium on Brain Structure in Bipolar Disorder

  2021cites this paper
• Brain Imaging Methods in Mood Disorders

  2021cites this paper
• Magnetoencephalography Studies in Mood Disorders

  2021cites this paper
• Neuroimaging Studies of Effects of Psychotherapy in Depression

  2021cites this paper
• An Overview of Machine Learning Applications in Mood Disorders

  2021cites this paper
• Neuroanatomical Findings in Bipolar Disorder

  2021cites this paper
• Neuroimaging Brain Inflammation in Mood Disorders

  2021cites this paper
• Brain Imaging and the Mechanisms of Antidepressant Action

  2021cites this paper
• Resting-State Functional Connectivity in Unipolar Depression

  2021cites this paper
• Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders

  2021cites this paper
• Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder

  2021cites this paper
• Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus

  2021cites this paper
• Neuroimaging Biomarkers in Pediatric Mood Disorders

  2021cites this paper
• New concepts in the development of schizophrenia, autism spectrum disorders, and degenerative brain diseases based on chronic inflammation: A working hypothesis from continued advances in neuroscience research

  2021cites this paper
• Imaging Genetic and Epigenetic Markers in Mood Disorders

  2021cites this paper
• B0 shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

  2020cites this paper
• Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study

  2020cites this paper
• Neuro‐metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy

  2019cites this paper
• Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex.

  2019cites this paper
• The potential of 1H-MRS in CNS drug development

  2019cites this paper
• Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

  2018cites this paper
• Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

  2018cites this paper
• Vinpocetine halts ketamine-induced schizophrenia-like deficits in rats: impact on BDNF and GSK-3β/β-catenin pathway

  2018cites this paper
• Functional Magnetic Resonance Spectroscopy: The “New” MRS for Cognitive Neuroscience and Psychiatry Research

  2018cites this paper
• Glutamatergic Response to Heat Pain Stress in Schizophrenia

  2018cites this paper
• Effects of repeated dizocilpine treatment on glutamatergic activity in the prefrontal cortex in an animal model of schizophrenia: An in vivo proton magnetic resonance spectroscopy study at 9.4T.

  2017cites this paper
• Temporal Dynamics of Antidepressant Ketamine Effects on Glutamine Cycling Follow Regional Fingerprints of AMPA and NMDA Receptor Densities

  2017cites this paper
• Metabolic alterations in the rat cerebellum following acute middle cerebral artery occlusion, as determined by 1H NMR spectroscopy.

  2017cites this paper
• Nardostachys jatamansi Targets BDNF-TrkB to Alleviate Ketamine-Induced Schizophrenia-Like Symptoms in Rats

  2017cites this paper
• 7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings.

  2017cites this paper
• Altered Glutamate and Regional Cerebral Blood Flow Levels in Schizophrenia: A 1H-MRS and pCASL study

  2017cites this paper
• Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline

  2016cites this paper
• Hippocampal proteomic and metabonomic abnormalities in neurotransmission and oxidative stress pathways in a chronic phencyclidine rat model

  2016cites this paper
• T proton magnetic resonance spectroscopy of GABA , glutamate , and glutamine reveals altered concentrations in schizophrenia patients and healthy siblingsGABA and glutamate in schizophrenia patients and siblings

  2016cites this paper
• Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

  2016cites this paper
• Molecular Substrates of Schizophrenia: Homeostatic Signaling to Connectivity

  2015cites this paper
• Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.

  2015cites this paper
• Anterior cingulate Glutamate-Glutamine cycle metabolites are altered in euthymic bipolar I disorder.

  2015cites this paper
• Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents.

  2015cites this paper
• An Examination of Rostral Anterior Cingulate Cortex Function and Neurochemistry in Obsessive–Compulsive Disorder

  2015cites this paper
• Brain and cognition abnormalities in long-term anabolic-androgenic steroid users.

  2015cites this paper
• Relationship among Glutamine, γ-Aminobutyric Acid, and Social Cognition in Autism Spectrum Disorders

  2015cites this paper
• Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo

  2015cites this paper
• In vivo neurometabolic profiling to characterize the effects of social isolation and ketamine-induced NMDA antagonism: a rodent study at 7.0 T.

  2014cites this paper
• Increased glutamine in patients undergoing long-term treatment for schizophrenia: a proton magnetic resonance spectroscopy study at 3 T.

  2014cites this paper
• Glutamate-mediated excitotoxicity in schizophrenia: a review.

  2014cites this paper
• Effects of acute phencyclidine administration on arginine metabolism in the hippocampus and prefrontal cortex in rats.

  2014cites this paper
• Neuropharmacological and Neurobiological Relevance of In vivo 1H-MRS of GABA and Glutamate for Preclinical Drug Discovery in Mental Disorders

  2014cites this paper
• Neurochemical Changes in the Rat Occipital Cortex and Hippocampus after Repetitive and Profound Hypoglycemia During the Neonatal Period: An Ex Vivo 1H Magnetic Resonance Spectroscopy Study

  2013cites this paper
• Metabolic Flux and Compartmentation Analysis in the Brain In vivo

  2013cites this paper
• Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions

  2013cites this paper
• Animal models and high field imaging and spectroscopy

  2013cites this paper
• Glutamate in schizophrenia: a focused review and meta-analysis of ¹H-MRS studies.

  2013cites this paper
• Relationship between Glutamate Dysfunction and Symptoms and Cognitive Function in Psychosis

  2013cites this paper
• Exploration of the Neurochemistry, Structural Morphology and Behavior in the GCPII+/- Mouse Model with Magnetic Resonance

  2013cites this paper
• An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression.

  2012influential citation
• Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders.

  2012cites this paper
• The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia

  2012cites this paper
• N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.

  2012cites this paper
• Simultaneous Measurement of Glucose Blood–Brain Transport Constants and Metabolic Rate in Rat Brain using in-vivo1H MRS

  2012influential citation
• Cortical Metabolites as Biomarkers in the R6/2 Model of Huntington's Disease

  2012cites this paper
• Brain Imaging in Behavioral Neuroscience

  2012cites this paper
• Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: Implications for neurodevelopmental disorders

  2012cites this paper
• ¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism.

  2012cites this paper
• The glutamate hypothesis of schizophrenia: neuroimaging and drug development.

  2012cites this paper
• The neurochemical profile quantified by in vivo 1H NMR spectroscopy

  2012cites this paper
• Neuroimaging as a Translational Tool in Animal and Human Models of Schizophrenia

  2012cites this paper
• Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo.

  2011cites this paper
• Acute Restraint-Mediated Increases in Glutamate Levels in the Rat Brain: An In Vivo 1H-MRS Study at 4.7 T

  2011cites this paper
• In vivo and ex vivo evidence for ketamine‐induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia

  2011cites this paper
• Magnetic resonance spectroscopy of in vivo tissue metabolism in small animals.

  2011cites this paper
• Current Awareness in NMR in Biomedicine

  2010cites this paper
• Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders.

  2010cites this paper
• Rapid Enhancement of Glutamatergic Neurotransmission in Bipolar Depression Following Treatment with Riluzole

  2010cites this paper
• Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.

  2009cites this paper
• Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis.

  2009cites this paper