Nitric oxide selectively suppresses IH currents mediated by HCN1‐containing channels

The superior olivary complex (SOC) exhibits a spectrum of HCN1 and HCN2 subunit expression, which generate IH currents with fast and slow kinetics, respectively. Neuronal nitric oxide synthase (nNOS) was broadly distributed across the SOC. NO hyperpolarizes the half‐activation voltage of HCN1‐mediated currents and caused a slowing of the IH current kinetics in the respective nuclei (medial and lateral superior olives and superior paraolivary nucleus). This signalling was independent of cGMP. NO also caused a depolarizing shift in the half‐activation voltage of HCN2‐mediated IH currents, increasing activation at resting potentials; this was cGMP‐dependent. Thus, NO signalling suppressed fast HCN1‐mediated currents and potentiated slow HCN2‐mediated currents, modulating the overall kinetics and magnitude of the endogenous IH.

• Publication year

  2015

• Venue

  Journal of Physiology

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2014.282194PMID 25605440PMCID PMC4386966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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