Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TAAP.2005.07.008PMID 16112698
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro.

  2005cited by this paper
• Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.

  2005cited by this paper
• Gene-Teratogen Interactions in Chemically Induced Congenital Malformations

  2004cited by this paper
• Anticonvulsant valproic acid inhibits cardiomyocyte differentiation of embryonic stem cells by increasing intracellular levels of reactive oxygen species.

  2003cited by this paper
• Management issues for women with epilepsy

  2003cited by this paper
• Molecular basis of environmentally induced birth defects.

  2003cited by this paper
• Amelioration of sodium valproate‐induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation

  2003cited by this paper
• Methylation and acetylation in nervous system development and neurodegenerative disorders.

  2003cited by this paper
• Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells.

  2003cited by this paper
• Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc.

  2003cited by this paper
• Constitutive nuclear factor-kappa B activity is required for central neuron survival.

  2002cited by this paper
• Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways.

  2002cited by this paper
• Dual effect of oxidative stress on NF-kappakB activation in HeLa cells.

  2002cited by this paper
• Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

  2002cited by this paper
• Dual effect of oxidative stress on NF-κB activation in HeLa cells

  2002cited by this paper
• Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.

  2002cited by this paper
• Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.

  2001cited by this paper
• Impact of extracellular folate levels on global gene expression.

  2001cited by this paper
• Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

  2001cited by this paper
• Neural tube defects : Prevention by folic acid and other vitamins

  2000cited by this paper
• Mouse models for neural tube closure defects.

  2000cited by this paper
• Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation.

  2000cited by this paper
• Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB.

  2000cited by this paper
• A Pathway of Neuronal Apoptosis Induced by Hypoxia/Reoxygenation

  2000cited by this paper
• Vitamin E decreases valproic acid induced neural tube defects in mice.

  2000cited by this paper
• Valproic acid-induced alterations in growth and neurotrophic factor gene expression in murine embryos [corrected].

  2000cited by this paper
• Homocysteine, folate enzymes and neural tube defects.

  1999cited by this paper
• Mini-review: toward understanding mechanisms of genetic neural tube defects in mice.

  1999cited by this paper
• Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.

  1999cited by this paper
• The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

  1999cited by this paper
• Cell death/apoptosis: normal, chemically induced, and teratogenic effect.

  1997cited by this paper
• Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

  1996cited by this paper
• Valproic acid-induced changes in gene expression during neurulation in a mouse model.

  1996cited by this paper
• Expression of mouse c-myb during embryonic development.

  1995cited by this paper
• Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I).

  1995cited by this paper
• Bcl-2 gene family and the regulation of programmed cell death.

  1994cited by this paper
• Epilepsy and pregnancy.

  1993cited by this paper
• Reversal of the Adverse Chronic Effects of the Unsaturated Derivative of Valproic Acid—2-n-Propyl-4-Pentenoic Acid—on Ketogenesis and Liver Coenzyme A Metabolism by a Single Injection of Pantothenate, Carnitine, and Acetylcysteine in Developing Mice

  1993cited by this paper
• Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.

  1992cited by this paper
• Mechanisms of teratogenesis: folic acid and antiepileptic therapy.

  1992cited by this paper
• Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic-acid-induced teratogenicity is time dependent.

  1991cited by this paper
• The cause of neural tube defects: some experiments and a hypothesis.

  1983cited by this paper
• Valproic acid and spina bifida.

  1982cited by this paper

• Abnormal enteric nervous system organization and gastrointestinal motility in mice with valproic acid-induced neural tube defects

  2026cites this paper
• Influence of Methylenetetrahydrofolate 677C > T Variant In Murine Models Following Valproic Acid Exposure.

  2025cites this paper
• Epilepsy in women of childbearing age: a focused review

  2025cites this paper
• A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate

  2025cites this paper
• Gcm1 Orchestrates Lef1 Expression in Folate Deficiency-Induced Neural Tube Defects

  2025cites this paper
• Maternal Immune Stimulation With Interferon‐Gamma Limits Embryonic Valproic Acid Induced Apoptotic Gene Expression

  2025cites this paper
• Intralitter Variability Influences the Developmental Impact of Valproic Acid Exposure in CD‐1 Mice

  2025cites this paper
• Valproic Acid in Pregnancy Revisited: Neurobehavioral, Biochemical and Molecular Changes Affecting the Embryo and Fetus in Humans and in Animals: A Narrative Review

  2023cites this paper
• Anti-inflammatory and protective effects of royal jelly against hepatic and renal damage induced by valproic acid in rats

  2023cites this paper
• Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses

  2022cites this paper
• Folic Acid Rescues Valproic Acid-Induced Morphogenesis Inhibition in Neural Rosettes Derived From Human Pluripotent Stem Cells

  2022cites this paper
• Effect of Valproic Acid on Pre and Postnatal Development of the Cerebellar Cortex of the Albino Rat and the Possible Protective Role of the Folic Acid

  2022cites this paper
• Exploring phytotherapeutic approach in the management of valproic acid-induced toxicity

  2021cites this paper
• Characterizing the effects of in utero valproic acid exposure on murine fetoplacental development.

  2021cites this paper
• Folic acid supplementation rescues valproic acid‐induced developmental neurotoxicity and behavioral alterations in zebrafish embryos

  2021cites this paper
• Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.

  2021cites this paper
• Gestational valproic acid exposure induces epigenetic modifications in murine decidua.

  2021cites this paper
• Role of environmental factors and epigenetics in autism spectrum disorders.

  2020cites this paper
• Characterizing the effects of in utero valproic acid exposure on NF-κB signaling in CD-1 mouse embryos during neural tube closure.

  2020cites this paper
• Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects.

  2020cites this paper
• Role of Cbp, p300 and Akt in valproic acid induced neural tube defects in CD-1 mouse embryos.

  2020cites this paper
• M2-like cells from the macrophage lineage might play a central role in closure of the embryonic neural tube.

  2019cites this paper
• Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development.

  2019cites this paper
• MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia

  2018cites this paper
• Anti-teratogenic potential and curtailing toxicity of valproic acid

  2018cites this paper
• Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human.

  2018cites this paper
• Developing a link between toxicants, claudins and neural tube defects.

  2018cites this paper
• Passive Addiction and Teratogenic Effects

  2018cites this paper
• A Study of The Effect of Prenatal Exposure to Valproic Acid on The Cerebellum of Albino Rat’s Offspring and The Possible Protective Role of Folic Acid

  2018cites this paper
• Механизмы вальпроат-индуцированного тератогенеза

  2017cites this paper
• Folate receptors and neural tube closure

  2017cites this paper
• Valproic acid increases NF-κB transcriptional activation despite decreasing DNA binding ability in P19 cells, which may play a role in VPA-initiated teratogenesis.

  2017cites this paper
• Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity.

  2017cites this paper
• COMPUTATIONAL ANALYSIS OF INTERACTIONS BETWEEN ANTI-EPILEPTIC DRUGS AND IMPORTANT PLACENTAL PROTEINS-A POSSIBLE ROUTE FOR NEURAL TUBE DEFECTS IN HUMANS

  2016cites this paper
• EXAMINATION OF THE EFFECTS OF VALPROIC ACID EXPOSURE OR P300 PROTEIN INHIBITION ON THE BALANCE OF APOPTOSIS AND PROLIFERATION IN P19 EMBRYONAL CARCINOMA CELLS

  2016influential citation
• Critical periods and neurodevelopmental brain disorders

  2016cites this paper
• Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells.

  2016influential citation
• Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling.

  2016cites this paper
• Sensitive and critical periods during neurotypical and aberrant neurodevelopment: a framework for neurodevelopmental disorders.

  2015cites this paper
• The Effects of Valproic Acid on the Skeletal Development and the Ameliorative Effects of Combined Use of Folic Acid and Vitamin E in Pregnant Albino Rats

  2015cites this paper
• The Phosphorylation State of GSK3β Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration

  2015cites this paper
• Valproic acid effects on renal corpuscle of pregnant rats: Defensive Strategies of folic acid and vitamin E

  2014cites this paper
• Role of folic acid in chlorpyrifos induced teratogenicity in mice

  2014cites this paper
• Teratogenic activity of HDAC inhibitors.

  2014cites this paper
• Effects of royal jelly on genotoxicity and nephrotoxicity induced by valproic acid in albino mice

  2014cites this paper
• Genetic variations in the GLUT3 gene associated with myelomeningocele.

  2014cites this paper
• A scientific review: mechanisms of valproate-mediated teratogenesis

  2013cites this paper
• Inhibition of nitric oxide synthesis enhances teratogenic effects induced by valproic Acid.

  2013cites this paper
• Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid.

  2013cites this paper
• Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

  2012cites this paper
• EFECTO DE LA SPIRULINA MAXIMA CONTRA LA TERATOGENICIDAD Y GENOTOXICIDAD PRODUCIDAS POR HIDROXIUREA

  2012cites this paper
• Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis.

  2012cites this paper
• Spirulina (Arthrospira) Protects Against Valproic Acid–Induced Neural Tube Defects in Mice

  2012cites this paper
• The Role of Oxidative Stress and Epigenetic Modifications in Valproic Acid-Induced Teratogenesis in the Mouse

  2012cites this paper
• The chick cardiomyocyte micromass system and stem cell differentiation along specific pathways : prediction of embryotoxic effects and their mechanism

  2012cites this paper
• iomarkers of teratogenesis : Suggestions from animal studies

  2012cites this paper
• Biomarkers of teratogenesis: suggestions from animal studies.

  2012cites this paper
• Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice

  2011cites this paper
• Valproic acid-induced DNA damage increases embryonic p27(KIP1) and caspase-3 expression: a mechanism for valproic-acid induced neural tube defects.

  2011cites this paper
• Valproic Acid Induced Fetal Malformations Are Reduced by Maternal Immune Stimulation with Granulocyte-Macrophage Colony-Stimulating Factor or Interferon γ

  2011cites this paper
• Genetic basis of susceptibility to teratogen induced birth defects

  2011cites this paper
• Developmental Toxicity of Antiepileptic Drugs

  2010cites this paper
• Epigenetic modifications in valproic acid-induced teratogenesis.

  2010cites this paper
• VPA-related axial skeletal defects and apoptosis: a proposed event cascade.

  2010cites this paper
• The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E

  2010cites this paper
• Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity.

  2010cites this paper
• Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation.

  2009cites this paper
• Autism and Parkinson's Disease: Animal Models and a Common Etiological Mechanism

  2009cites this paper
• Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects.

  2009cites this paper
• All‐trans‐retinoic acid alters Smads expression in embryonic neural tissue of mice

  2009cites this paper
• Ascorbic Acid Reverses Valproic Acid-Induced Inhibition of Hoxa2 and Maintains Glutathione Homeostasis in Mouse Embryos in Culture

  2009cites this paper
• Valproic acid in pregnancy: how much are we endangering the embryo and fetus?

  2009cites this paper
• Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress.

  2008cites this paper
• Reactive oxygen species, diabetes and toxicity in the placenta - a workshop report.

  2008cites this paper
• Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency

  2008cites this paper
• TNFalpha in the pathogenesis of diabetes-induced embryopathies: functions and targets.

  2007cites this paper
• Effect of valproic acid on glutathione homeostasis in mouse whole embryo cultures

  2007cites this paper
• Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma.

  2006cites this paper
• Valproic Acid in Epilepsy

  2006cites this paper
• My approach to performing a perinatal or neonatal autopsy

  2006cites this paper