Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Blood

• Publication date

  2010-09-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood-2010-03-272278PMID 20505157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IMGT, the International ImMunoGeneTics Information System.

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  2004cited by this paper
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  2004cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Prognostic value of chromosomal abnormalities in follicular lymphoma.

  1994cited by this paper
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  1987cited by this paper
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  1982cited by this paper
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  year unknowninfluential reference
• Follicular Lymphoma: Early Direct or Late from Fl Progenitor Cells Mutation Patterns Suggest Different Progression Pathways in Μ S

  year unknowncited by this paper

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  2012cites this paper
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