Methanol/sorbitol co-feeding induction enhanced porcine interferon-α production by P. pastoris associated with energy metabolism shift

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Bioprocess and biosystems engineering (Print)

• Publication date

  2012-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00449-012-0697-1PMID 22349926
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Converging toward a common speech code: imitative and perceptuo-motor recalibration processes in speech production

  2013cited by this paper
• Improvement of ATP regeneration efficiency and operation stability in porcine interferon-α production by Pichia pastoris under lower induction temperature

  2011cited by this paper
• Effective and stable porcine interferon-α production by Pichia pastoris fed-batch cultivation with multi-variables clustering and analysis

  2010cited by this paper
• Enhanced porcine interferon-α production by recombinant Pichia pastoris with a combinational control strategy of low induction temperature and high dissolved oxygen concentration

  2010influential reference
• Enhancement of cell viability and alkaline polygalacturonate lyase production by sorbitol co-feeding with methanol in Pichia pastoris fermentation.

  2010cited by this paper
• Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation.

  2010cited by this paper
• [Comparison of antiviral activities of porcine interferon type I and type II].

  2009cited by this paper
• Lowering induction temperature for enhanced production of polygalacturonate lyase in recombinant Pichia pastoris

  2009cited by this paper
• Fed‐batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co‐substrate sorbitol

  2009cited by this paper
• Pichia Protocols

  2007cited by this paper
• Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures: A quantitative study based on concentration gradients in transient continuous cultures.

  2007cited by this paper
• Regulation of alcohol oxidase of a recombinant Pichia pastoris Mut+ strain in transient continuous cultures.

  2007cited by this paper
• Effective induction of phytase in Pichia pastoris fed-batch culture using an ANN pattern recognition model-based on-line adaptive control strategy

  2007cited by this paper
• Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris.

  2007cited by this paper
• A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris.

  2007cited by this paper
• The significance of peroxisomes in methanol metabolism in methylotrophic yeast.

  2006cited by this paper
• An on-line adaptive control based on DO/pH measurements and ANN pattern recognition model for fed-batch cultivation

  2006cited by this paper
• Use of different carbon sources in cultivation of recombinant Pichia pastoris for angiostatin production

  2005cited by this paper
• Heterologous protein production using the Pichia pastoris expression system

  2005cited by this paper
• Secretive Expression of Porcine IFN-α in Yeast Pichia pastoris

  2005cited by this paper
• Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha

  2005cited by this paper
• [Gene modification and high prokaryotic expression of porcine interferon alpha-1].

  2004cited by this paper
• Directed evolution of single-chain Fv for cytoplasmic expression using the β-galactosidase complementation assay results in proteins highly susceptible to protease degradation and aggregation

  2004cited by this paper
• Novel Viral Disease Control Strategy: Adenovirus Expressing Alpha Interferon Rapidly Protects Swine from Foot-and-Mouth Disease

  2003cited by this paper
• Temperature limited fed-batch technique for control of proteolysis in Pichia pastoris bioreactor cultures

  2003cited by this paper
• Pichia pastoris fermentation with mixed-feeds of glycerol and methanol: growth kinetics and production improvement

  2003cited by this paper
• Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris.

  2002cited by this paper
• Modeling of growth and energy metabolism of Pichia pastoris producing a fusion protein

  2002cited by this paper
• Physiological role of the glutathione-dependent formaldehyde dehydrogenase in the methylotrophic yeast Candida boidinii.

  2002cited by this paper
• Heterologous protein expression in the methylotrophic yeast Pichia pastoris.

  2000cited by this paper
• The Pichia pastoris dihydroxyacetone kinase is a PTS1‐containing, but cytosolic, protein that is essential for growth on methanol

  1998cited by this paper
• Interaction of ${\alpha}$-Ketoglutarate Dehydrogenase Complex with Allosteric Regulators Detected by a Fluorescence Probe, 1,1'-bi(4-aniline)naphthalene-5,5'-disulfonic acid, an Inhibitor of Catalytic Activity

  1996cited by this paper
• Screening and Identification of Candida methanosorbosa as Alcohol Oxidase-producing Methanol Using Yeast

  1990cited by this paper
• NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: Support of steroid hydroxylation

  1985cited by this paper
• Production of Lysine by Pyruvate Dehydrogenase Mutants of Brevibacterium flavum

  1984cited by this paper
• Purification and properties of formaldehyde dehydrogenase and formate dehydrogenase from Candida boidinii.

  1976cited by this paper

• The optimized signal peptide and feeding strategy to enhance secretory expression of LegH in Komagataella phaffii

  2025cites this paper
• Optimizated Prolyl‐4‐Hydroxylase Expression in Komagataella phaffii Enables Efficient Triple‐Helix Formation of Recombinant Human Collagen

  2025cites this paper
• Enhance Protein Secretion Pathway and Energy Metabolism to Improved Protein Activity in Recombinant Pichia pastoris

  2025cites this paper
• Efficient production of human lysozyme by recombinant Pichia pastoris via periodic methanol/glycerol feeding control and its applications in strawberry preservation

  2024cites this paper
• Effect and mechanism of signal peptide and maltose on recombinant type III collagen production in Pichia pastoris

  2023cites this paper
• Recent Developments in Bioprocessing of Recombinant Antibody Fragments

  2023cites this paper
• A multi-model predictive control method for the Pichia pastoris fermentation process based on relative error weighting algorithm

  2022cites this paper
• P AOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol consumption regardless of the secondary carbon source

  2022cites this paper
• Study on Multi-Model Soft Sensor Modeling Method and Its Model Optimization for the Fermentation Process of Pichia pastoris

  2021cites this paper
• Controlling speci c growth rate for recombinant protein production by Pichia pastoris under oxidation stress in fed-batch fermentation

  2021cites this paper
• Enhancing HSA-GCSFm fusion protein production by Pichia pastoris with an on-line model-based exponential and DO-stat control modes

  2021cites this paper
• Controlling Specific Growth Rate for Recombinant Protein Production by Pichia pastoris Under Oxidation Stress in Fed-batch Fermentation

  2021cites this paper
• PAOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol uptake regardless of the secondary carbon source: a simplifying principle for predicting recombinant protein production

  2021cites this paper
• Dual Regulation of Cytoplasm and Peroxisomes for Improved Α-Farnesene Production in Recombinant Pichia pastoris.

  2021cites this paper
• Fermentation, Purification, and Tumor Inhibition of a Disulfide-Stabilized Diabody Against Fibroblast Growth Factor-2

  2021cites this paper
• Enhanced human lysozyme production by Pichia pastoris via periodic glycerol and dissolved oxygen concentrations control

  2021cites this paper
• Development of a New High-Cell Density Fermentation Strategy for Enhanced Production of a Fungus β-Glucosidase in Pichia pastoris

  2020cites this paper
• Pichia pastoris: A highly successful expression system for optimal synthesis of heterologous proteins

  2020cites this paper
• Microbioreactor for lower cost and faster optimisation of protein production.

  2020cites this paper
• Microfluidic Microbioreactor to Reduce the Cost and Speed Up Optimisation of Protein Production

  2020cites this paper
• Controlling methanol feeding for recombinant protein production by Pichia pastoris under oxidation stress in fed-batch fermentation

  2020cites this paper
• Development of new cultivation strategies to enhance heterologous protein production in Pichia pastoris

  2019influential citation
• Functional expression of porcine interferon-α using a combinational strategy in Pichia pastoris GS115.

  2019cites this paper
• Expression of recombinant enhanced green fluorescent protein provides insight into foreign gene‐expression differences between Mut+ and MutS strains of Pichia pastoris

  2019cites this paper
• Statistically Designed Medium Reveals Interactions between Metabolism and Genetic Information Processing for Production of Stable Human Serum Albumin in Pichia pastoris

  2019cites this paper
• Sorbitol/methanol mixed induction reduces process impurities and improves centrifugal dewatering in Pichia pastoris culture.

  2019cites this paper
• Evaluation of the sub-optimal induction strategies for heterologous proteins production by Pichia pastoris Mut+/MutS strains and related transcriptional and metabolic analysis

  2018cites this paper
• Bioprocess and downstream optimization of recombinant human growth hormone in Pichia pastoris

  2018cites this paper
• Transcriptional analysis for carbon metabolism and kinetic modeling for heterologous proteins productions by Pichia pastoris in induction process with methanol/sorbitol co-feeding

  2017cites this paper
• A comparative study of glycerol and sorbitol as co-substrates in methanol-induced cultures of Pichia pastoris: temperature effect and scale-up simulation

  2017cites this paper
• Evaluation of Sorbitol-Methanol Co-Feeding Strategy on Production of Recombinant Human Growth Hormone in Pichia Pastoris

  2017cites this paper
• Integrating metabolic modeling and population heterogeneity analysis into optimizing recombinant protein production by Komagataella (Pichia) pastoris

  2017cites this paper
• Engineering strategies for enhanced production of protein and bio-products in Pichia pastoris: A review.

  2017cites this paper
• Cofactor engineering improved CALB production in Pichia pastoris through heterologous expression of NADH oxidase and adenylate kinase

  2017cites this paper
• [Transcriptome analysis of Pichia pastoris in response to ethanol stress].

  2016cites this paper
• An upstream platform for the production of high grade heterologous proteins in the yeast Pichia pastoris

  2016influential citation
• A comparative study of glycerol and sorbitol as co‐substrates in methanol‐induced cultures of Pichia pastoris: temperature effect and scale‐up simulation

  2016cites this paper
• Secreted expression of truncated capsid protein from porcine circovirus type 2 in Pichia pastoris

  2016cites this paper
• Methanol feeding strategy design enhances recombinant human growth hormone production by Pichia pastoris

  2016cites this paper
• Improving Performance and Operational Stability of Porcine Interferon-α Production by Pichia pastoris with Combinational Induction Strategy of Low Temperature and Methanol/Sorbitol Co-feeding

  2015cites this paper
• High-level expression and characterization of a thermostable xylanase mutant from Trichoderma reesei in Pichia pastoris.

  2015cites this paper
• Effect of Ethanol Accumulation on Porcine Interferon-α Production by Pichia pastoris and Activities of Key Enzymes in Carbon Metabolism

  2015cites this paper
• Enhanced secretion of a methyl parathion hydrolase in Pichia pastoris using a combinational strategy

  2015cites this paper
• Genetic engineering of nonconventional yeasts for the production of valuable compounds

  2015cites this paper
• Improving the Secretion of a Methyl Parathion Hydrolase in Pichia pastoris by Modifying Its N-Terminal Sequence

  2014cites this paper
• Pichia pastoris: a workhorse for recombinant protein production

  2014cites this paper
• Stabilizing porcine interferon‐α production by Pichia pastoris with an ethanol on‐line measurement based DO‐Stat glycerol feeding strategy

  2014cites this paper
• Small-scale slow glucose feed cultivation of Pichia pastoris without repression of AOX1 promoter: towards high throughput cultivations

  2014cites this paper
• Enhanced porcine circovirus Cap protein production by Pichia pastoris with a fuzzy logic DO control based methanol/sorbitol co-feeding induction strategy.

  2014cites this paper
• Efficient secretion of inulin fructotransferase in Pichia pastoris using the formaldehyde dehydrogenase 1 promoter

  2014cites this paper
• Effect of co‐substrate sorbitol different feeding strategies on human growth hormone production by recombinant Pichia pastoris

  2013cites this paper
• A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

  2013cites this paper
• Process Control and Optimization for Heterologous Protein Production by Methylotrophic Pichia pastoris

  2013cites this paper
• Investigating the physiological response of Pichia (Komagataella) pastoris GS115 to the heterologous expression of misfolded proteins using chemostat cultures

  2013cites this paper