IJD® 2012: A Progress Report

K. Lahiri

Published 2013 in Indian Journal of Dermatology

ABSTRACT

IN public health circles, where immunity is normally equated with resistance, Rh hemolytic disease of the newborn is paradoxical because it affects only subjects who are immune. Since the Rh factor occurs in nature only in the red cells of humans or primates, the one way an Rh-negative mother can become immunized to this antigen is by leakage of Rh-positive fetal red cells into her circulation during pregnancy or labor, or from the injection of Rh-positive blood. Following exposure to Rh antigen in one of these two ways, Rh-negative women in a percentage of cases will respond by forming anti-Rh antibodies. When such an immunized woman becomes pregnant with an Rh-positive fetus anti-Rh antibody will cross the placenta into the fetal cir-

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