PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-&kgr;B- and HDAC1-mediated expression and activation of uPA

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.106542PMID 22797919PMCID PMC4074284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion.

  2011influential reference
• Protein Kinase D2 Is an Essential Regulator of Murine Myoblast Differentiation

  2011cited by this paper
• Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.

  2011cited by this paper
• Protein Kinase D Is Implicated in the Reversible Commitment to Differentiation in Primary Cultures of Mouse Keratinocytes*

  2010cited by this paper
• Protein kinase D2 is a crucial regulator of tumour cell–endothelial cell communication in gastrointestinal tumours

  2010cited by this paper
• Protein Kinase D Controls Actin Polymerization and Cell Motility through Phosphorylation of Cortactin*

  2010cited by this paper
• TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells.

  2010cited by this paper
• Epidermal Growth Factor Receptor-Mediated Regulation of Urokinase Plasminogen Activator Expression and Glioblastoma Invasion via C-SRC/MAPK/AP-1 Signaling Pathways

  2010cited by this paper
• Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.

  2010cited by this paper
• ULTRAVIOLET B IRRADIATION AND ACTIVATION OF PROTEIN KINASE D IN PRIMARY MOUSE EPIDERMAL KERATINOCYTES

  2010influential reference
• Protein Kinase D1 Is Essential for the Proinflammatory Response Induced by Hypersensitivity Pneumonitis-Causing Thermophilic Actinomycetes Saccharopolyspora rectivirgula

  2010cited by this paper
• Selective transcription in response to an inflammatory stimulus.

  2010cited by this paper
• The NF-kappaB family of transcription factors and its regulation.

  2009cited by this paper
• Protein Kinase D1 Is Essential for MyD88-Dependent TLR Signaling Pathway1

  2009cited by this paper
• BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-κB binding site of the uPA promoter

  2009cited by this paper
• Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

  2009influential reference
• PKD3 Is the Predominant Protein Kinase D Isoform in Mouse Exocrine Pancreas and Promotes Hormone-induced Amylase Secretion*

  2009cited by this paper
• Bone Morphogenic Protein 2 Activates Protein Kinase D to Regulate Histone Deacetylase 7 Localization and Repression of Runx2*

  2009cited by this paper
• Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.

  2009cited by this paper
• PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells.

  2009influential reference
• Chfr is linked to tumour metastasis through the downregulation of HDAC1

  2009cited by this paper
• Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.

  2008cited by this paper
• β‐catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E‐cadherin and protein kinase D1

  2008influential reference
• Evolving role of uPA/uPAR system in human cancers.

  2008influential reference
• Protein kinase D isozymes activation and localization during mitosis.

  2008cited by this paper
• Inflammation and prostate cancer: a future target for prevention and therapy?

  2008cited by this paper
• Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.

  2008cited by this paper
• Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2.

  2007cited by this paper
• Histone deacetylases and cancer

  2007influential reference
• Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

  2007cited by this paper
• Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells.

  2007cited by this paper
• Targeting uPA/uPAR in prostate cancer.

  2007cited by this paper
• Inhibition of Histone Deacetylase Activity Promotes Invasion of Human Cancer Cells through Activation of Urokinase Plasminogen Activator*

  2007influential reference
• Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-κB-dependent activation of the urokinase plasminogen activator system

  2006cited by this paper
• Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer

  2006cited by this paper
• Tumour necrosis factor‐α depletes histone deacetylase 1 protein through IKK2

  2006influential reference
• Depletion of Histone Deacetylase I Protein: A Common Consequence of Inflammatory Cytokine Signaling?

  2006cited by this paper
• Essential Role for Protein Kinase D Family Kinases in the Regulation of Class II Histone Deacetylases in B Lymphocytes

  2006cited by this paper
• Tumour necrosis factor-alpha depletes histone deacetylase 1 protein through IKK2.

  2006influential reference
• PKD at the crossroads of DAG and PKC signaling.

  2006influential reference
• Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

  2005cited by this paper
• Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.

  2005cited by this paper
• E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer.

  2005influential reference
• Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.

  2005cited by this paper
• Signaling Mechanisms Responsible for Lysophosphatidic Acid-induced Urokinase Plasminogen Activator Expression in Ovarian Cancer Cells*

  2005cited by this paper
• A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.

  2005cited by this paper
• Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity

  2005cited by this paper
• Expression of the constitutively activated RelA/NF-κB in human astrocytic tumors and the in vitro implication in the regulation of urokinase-type plasminogen activator, migration, and invasion

  2005cited by this paper
• Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation

  2005cited by this paper
• A Novel NF-κB Pathway Involving IKKβ and p65/RelA Ser-536 Phosphorylation Results in p53 Inhibition in the Absence of NF-κB Transcriptional Activity*

  2005cited by this paper
• Phosphorylation of RelA/p65 on Serine 536 Defines an IκBα-independent NF-κB Pathway*

  2005cited by this paper
• Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells.

  2004cited by this paper
• Protein kinase D mediates a stress‐induced NF‐κB activation and survival pathway

  2003cited by this paper
• NF-κB Activates Prostate-Specific Antigen Expression and Is Upregulated in Androgen-Independent Prostate Cancer

  2002cited by this paper
• Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells.

  2002cited by this paper
• The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

  2002cited by this paper
• Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB.

  2002cited by this paper
• NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer.

  2002cited by this paper
• Protein Kinase C Induces Motility of Breast Cancers by Upregulating Secretion of Urokinase-Type Plasminogen Activator through Activation of AP-1 and NF-κB

  2002cited by this paper
• The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.

  2002cited by this paper
• Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

  2001cited by this paper
• Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis.

  2001cited by this paper
• Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen.

  1999cited by this paper
• Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen

  1999cited by this paper
• NF-kappa B-mediated regulation of urokinase gene expression by PMA and TNF-alpha in human A549 cells.

  1996cited by this paper
• NF‐κB‐mediated regulation of urokinase gene expression by PMA and TNF‐α in human A549 cells

  1996cited by this paper
• Effect of epidermal growth factor on prostate cancer cell line PC3 growth and invasion

  1994cited by this paper

• Golgi Drivers of Cancer.

  2026cites this paper
• Protein kinase D: Integrating cancer and metabolic disorders.

  2026cites this paper
• Targeting PRKCN, an Essential Driver Orchestrating mTOR-IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma.

  2026cites this paper
• A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis

  2025cites this paper
• Protein kinase D2-mediated maintenance complex component 2 phosphorylation promotes bladder cancer progression

  2025cites this paper
• Transcriptome Analysis Suggests PKD3 Regulates Proliferative Glucose Metabolism, Calcium Homeostasis and Microtubule Dynamics After MEF Spontaneous Immortalization

  2025cites this paper
• Polyamines signalling pathway: A key player in unveiling the molecular mechanisms underlying Huntington's disease.

  2025cites this paper
• Advances in sequencing and omics studies in prostate cancer: unveiling molecular pathogenesis and clinical applications

  2024cites this paper
• Propofol suppressed cell proliferation through inhibition of SREBP1c-mediated De novo lipogenesis in colorectal cancer cells

  2024cites this paper
• PRKD3 promotes proliferation of liver cancer cells: a downstream proteomics profiling study.

  2024cites this paper
• Rabeprazole suppressed gastric intestinal metaplasia through activation of GPX4-mediated ferroptosis

  2024cites this paper
• BRAT1 - a new therapeutic target for glioblastoma

  2024cites this paper
• Protein kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines

  2024cites this paper
• Protein kinase D2 and 3 promote prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner.

  2023cites this paper
• The novel mechanism of human norovirus induced diarrhea: Activation of PKD2 caused by HuNoVs destroyed AQP3 expression through AP2γ in intestinal epithelial cells.

  2023cites this paper
• Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.

  2023cites this paper
• Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a snail/ERK dependent mechanism.

  2023cites this paper
• Potential role for protein kinase D inhibitors in prostate cancer

  2023cites this paper
• Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration

  2023influential citation
• Addressing the role of PKD3 in the T cell compartment with knockout mice

  2022cites this paper
• Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.

  2022cites this paper
• Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1

  2022cites this paper
• Emerging photodynamic/sonodynamic therapies for urological cancers: progress and challenges

  2022cites this paper
• Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers

  2022cites this paper
• Golgi Complex: A Signaling Hub in Cancer

  2022cites this paper
• Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.

  2022cites this paper
• Protein kinase D promotes prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner

  2022cites this paper
• Targeting Protein Kinases and Epigenetic Control as Combinatorial Therapy Options for Advanced Prostate Cancer Treatment

  2022cites this paper
• iTRAQ-Based Proteome Profiling of Differentially Expressed Proteins in Insulin-Resistant Human Hepatocellular Carcinoma

  2022cites this paper
• Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases

  2021influential citation
• The oncogenic role of protein kinase D3 in cancer

  2021cites this paper
• Protein Kinase D3 Promotes the Reconstruction of OSCC Immune Escape Niche Via Regulating MHC-I and Immune Inhibit Molecules Expression

  2021cites this paper
• TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer

  2021cites this paper
• Developments in the Discovery and Design of Protein Kinase D Inhibitors

  2021cites this paper
• Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors.

  2020cites this paper
• Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection

  2020cites this paper
• N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1

  2020cites this paper
• Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

  2020cites this paper
• Npas4 impairs fear memory via phosphorylated HDAC5 induced by CGRP administration in mice

  2020cites this paper
• Protein kinase D3 regulates the expression of the immunosuppressive protein, PD-L1, through STAT1/STAT3 signaling

  2020cites this paper
• PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling

  2020cites this paper
• Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer.

  2020cites this paper
• High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial–mesenchymal Transition

  2019cites this paper
• Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer‐related pathways in breast cancer

  2019cites this paper
• Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

  2019cites this paper
• Protein kinase D3 promotes gastric cancer development through p65/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 activation of glycolysis.

  2019cites this paper
• The Role and Mechanism of CRT 0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer

  2019cites this paper
• The role of PKC and PKD in CXCL12 directed prostate cancer migration.

  2019cites this paper
• Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells

  2019influential citation
• The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role

  2018cites this paper
• Crosstalk of protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis

  2018cites this paper
• NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation

  2018cites this paper
• Protein kinase D2: a versatile player in cancer biology

  2018cites this paper
• TITLE : Targeting a Novel Androgen Receptor-Repressed Pathway in Prostate Cancer Therapy

  2018cites this paper
• Deciphering the role of SerpinB2 in cancer invasion and metastasis

  2017cites this paper
• Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors

  2017cites this paper
• Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients.

  2017cites this paper
• Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

  2017cites this paper
• Specific tumor-derived CCL2 mediated by pyruvate kinase M2 in colorectal cancer cells contributes to macrophage recruitment in tumor microenvironment

  2017cites this paper
• Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα

  2017cites this paper
• Protein kinase D signaling in cancer: A friend or foe?

  2017cites this paper
• Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

  2017cites this paper
• Protein Kinase D: A Potential Therapeutic Target in Prostate Cancer.

  2017cites this paper
• Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion

  2017cites this paper
• Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M

  2017cites this paper
• Detecting in vivo urokinase plasminogen activator activity with a catalyCEST MRI contrast agent

  2017cites this paper
• Validation de la protéine Kinase D1 comme facteur pronostique et cible thérapeutique dans le cancer du sein triple négatif et analyse de son rôle dans le maintien du phénotype mésenchymateux dans le mélanome

  2017cites this paper
• TRPP2 Enhances Metastasis by Regulating Epithelial-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma

  2016cites this paper
• TRPP 2 Enhances Metastasis by Regulating Epithelial-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma

  2016cites this paper
• A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms

  2016cites this paper
• Subtilase cytotoxin produced by locus of enterocyte effacement‐negative Shiga‐toxigenic Escherichia coli induces stress granule formation

  2016influential citation
• Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion

  2016cites this paper
• Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases.

  2016influential citation
• The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2.

  2015cites this paper
• Opposing Growth Regulatory Roles of Protein Kinase D Isoforms in Human Keratinocytes*

  2015cites this paper
• Efficient gene and siRNA delivery with cationic polyphosphoramide with amino moieties in the main chain

  2015cites this paper
• Protein Kinase D 3 Is Essential for Prostratin-Activated Transcription of Integrated HIV-1 Provirus Promoter via NF-κ B Signaling Pathway

  2015cites this paper
• Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer

  2015cites this paper
• Evaluation and integration of cancer gene classifiers: identification and ranking of plausible drivers

  2015cites this paper
• Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro

  2015cites this paper
• Effective Targeting of Estrogen Receptor–Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101

  2015cites this paper
• Isoliensinine, a Bioactive Alkaloid Derived from Embryos of Nelumbo nucifera, Induces Hepatocellular Carcinoma Cell Apoptosis through Suppression of NF-κB Signaling.

  2015cites this paper
• Protein kinase D2 contributes to TNF-α-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3β/β-catenin pathway in hepatocellular carcinoma

  2015cites this paper
• Plasminogen Activator Inhibitor Type-2 (PAI-2)/SerpinB2: A Unique Multifunctional Serpin

  2015cites this paper
• Isoform specific functions of protein kinase D3 (PKD3) in breast cancer cell proliferation and motility

  2014cites this paper
• Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.

  2014cites this paper
• Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways

  2014cites this paper
• Protein Kinase D3 Is Essential for Prostratin-Activated Transcription of Integrated HIV-1 Provirus Promoter via NF-κB Signaling Pathway

  2014cites this paper
• Protein Kinase D Isoforms Differentially Modulate Cofilin-Driven Directed Cell Migration

  2014cites this paper
• Hope and Fear for Interferon: The Receptor-Centric Outlook on the Future of Interferon Therapy

  2013cites this paper
• Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro

  2013cites this paper
• Elevated Protein Kinase D3 (PKD3) Expression Supports Proliferation of Triple-negative Breast Cancer Cells and Contributes to mTORC1-S6K1 Pathway Activation*

  2013cites this paper
• Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption

  2013cites this paper
• Rol de HO-1 en la regulación de la inflamación asociada al cáncer de próstata. Compartimentalización subcelular y función

  2013cites this paper
• Protein kinase D isoforms: new targets for therapy in invasive breast cancers?

  2013cites this paper
• Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein

  2012cites this paper
• World Journal of Clinical Oncology

  year unknowncites this paper