Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.

Here we report highly efficient and chemoselective azadiene-imine reductive couplings catalyzed by (Ph-BPE)Cu-H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products' diamines are easily differentiable, facilitating downstream synthesis.

• Publication year

  2018

• Venue

  Journal of the American Chemical Society

• Publication date

  2018-05-18

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jacs.8b04750PMID 29775301PMCID PMC5999589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.

  2018cited by this paper
• Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile.

  2018cited by this paper
• Lewis Acid Catalyzed Enantioselective Desymmetrization of Donor-Acceptor meso-Diaminocyclopropanes.

  2018cited by this paper
• Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05176j

  2018cited by this paper
• A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes.

  2018cited by this paper
• Enantioselective Synthesis of 1,2-Diamines Containing Tertiary and Quaternary Centers through Rhodium-Catalyzed DYKAT of Racemic Allylic Trichloroacetimidates.

  2017cited by this paper
• Highly Regio- and Enantioselective Copper-Catalyzed Reductive Hydroxymethylation of Styrenes and 1,3-Dienes with CO2.

  2017cited by this paper
• β-Selective Reductive Coupling of Alkenylpyridines with Aldehydes and Imines via Synergistic Lewis Acid/Photoredox Catalysis.

  2017cited by this paper
• Catalytic Enantioselective Carbonyl Allylation and Propargylation via Alcohol-Mediated Hydrogen Transfer: Merging the Chemistry of Grignard and Sabatier.

  2017cited by this paper
• Enantioselective Three-Component Amination of Enecarbamates Enables the Synthesis of Structurally Complex Small Molecules.

  2017cited by this paper
• Enantioselective CuH-Catalyzed Hydroacylation Employing Unsaturated Carboxylic Acids as Aldehyde Surrogates.

  2017cited by this paper
• Versatile Homoallylic Boronates by Chemo-, SN 2'-, Diastereo- and Enantioselective Catalytic Sequence of Cu-H Addition to Vinyl-B(pin)/Allylic Substitution.

  2017cited by this paper
• Catalytic Asymmetric Diamination of Styrenes.

  2017cited by this paper
• Synthesis of Chiral Vicinal Diamines by Silver(I)-Catalyzed Enantioselective Aminolysis of N-Tosylaziridines.

  2017cited by this paper
• Copper-catalyzed asymmetric addition of olefin-derived nucleophiles to ketones

  2016cited by this paper
• Copper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines Enabled by Ligand-Controlled Chemoselective Hydrocupration

  2016cited by this paper
• Coinage Metal Hydrides: Synthesis, Characterization, and Reactivity.

  2016cited by this paper
• Asymmetric Synthesis of Borylalkanes via Copper-Catalyzed Enantioselective Hydroallylation.

  2016cited by this paper
• Regiodivergent and Diastereoselective CuH-Catalyzed Allylation of Imines with Terminal Allenes.

  2016cited by this paper
• Enantioselective CuH-Catalyzed Reductive Coupling of Aryl Alkenes and Activated Carboxylic Acids

  2016cited by this paper
• Metal-catalyzed reductive coupling of olefin-derived nucleophiles: Reinventing carbonyl addition

  2016cited by this paper
• Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives.

  2016cited by this paper
• Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis

  2016cited by this paper
• Enantioselective CuH-Catalyzed Hydroallylation of Vinylarenes

  2016cited by this paper
• Nickel Catalysis: Synergy between Method Development and Total Synthesis.

  2015cited by this paper
• Versatile In Situ Generated N-Boc-Imines: Application to Phase-Transfer-Catalyzed Asymmetric Mannich-Type Reactions.

  2015cited by this paper
• Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas.

  2015cited by this paper
• N-Substituted tertiary and O-substituted quaternary carbon stereogenic centers by site-, diastereo- and enantioselective vinylogous Mannich reactions.

  2015cited by this paper
• Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines

  2015cited by this paper
• Catalytic Enantioselective Reaction of α-Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts.

  2015cited by this paper
• Diene hydroaminomethylation via ruthenium-catalyzed C–C bond forming transfer hydrogenation: beyond carbonylation

  2015cited by this paper
• Synergistic Catalysis of Ionic Brønsted Acid and Photosensitizer for a Redox Neutral Asymmetric α-Coupling of N-Arylaminomethanes with Aldimines.

  2015cited by this paper
• Catalytic asymmetric mannich-type reaction of N-alkylidene-α-aminoacetonitrile with ketimines.

  2015cited by this paper
• Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach

  2015cited by this paper
• Ruthenium-catalyzed C-C coupling of amino alcohols with dienes via transfer hydrogenation: redox-triggered imine addition and related hydroaminoalkylations.

  2015cited by this paper
• Hydroaminomethylation Beyond Carbonylation: Allene-Imine Reductive Coupling by Ruthenium-Catalyzed Transfer Hydrogenation.

  2015cited by this paper
• Enantioselective Diamination with Novel Chiral Hypervalent Iodine Catalysts

  2014cited by this paper
• Catalytic Diamination of Olefins via N–N Bond Activation

  2014cited by this paper
• Copper-Catalyzed Alkene Diamination: Synthesis of Chiral 2-Aminomethyl Indolines and Pyrrolidines.

  2014cited by this paper
• Catalytic imine-imine cross-coupling reactions.

  2014cited by this paper
• Highly enantioselective intermolecular hydroamination of allylic amines with chiral aldehydes as tethering catalysts.

  2013cited by this paper
• Ruthenium(II)-catalyzed regioselective reductive coupling of α-imino esters with dienes.

  2013cited by this paper
• Enantioselective palladium-catalyzed diamination of alkenes using N-fluorobenzenesulfonimide.

  2013cited by this paper
• Ruthenium catalyzed hydroaminoalkylation of isoprene via transfer hydrogenation: byproduct-free prenylation of hydantoins.

  2013cited by this paper
• Catalytic asymmetric synthesis of cyclic sulfamides from conjugated dienes.

  2013cited by this paper
• A chiral bis(betaine) catalyst for the Mannich reaction of azlactones and aliphatic imines.

  2012cited by this paper
• Enantioselective copper-catalyzed reductive coupling of alkenylazaarenes with ketones.

  2012cited by this paper
• Stereocontrolled synthesis of vicinal diamines by organocatalytic asymmetric Mannich reaction of N-protected aminoacetaldehydes: formal synthesis of (-)-agelastatin A.

  2012cited by this paper
• Diastereo- and enantioselective catalytic vinylogous Mukaiyama-Mannich reactions of pyrrole-based silyl dienolates with alkyl-substituted aldehydes.

  2011cited by this paper
• Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods.

  2011cited by this paper
• Enantioselective nickel-catalyzed reductive coupling of alkynes and imines.

  2010cited by this paper
• Copper-promoted and copper-catalyzed intermolecular alkene diamination.

  2010cited by this paper
• Catalytic carbon-carbon bond-forming reactions of aminoalkane derivatives with imines.

  2010cited by this paper
• Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

  2010cited by this paper
• Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.

  2010cited by this paper
• Cycle-specific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis.

  2009cited by this paper
• Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of alpha,beta-diamino acids.

  2009cited by this paper
• Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

  2009cited by this paper
• Direct Mannich reaction of glycinate Schiff bases with N-(8-quinolyl)sulfonyl imines: a catalytic asymmetric approach to anti-alpha,beta-diamino esters.

  2008cited by this paper
• Branch-selective reductive coupling of 2-vinyl pyridines and imines via rhodium catalyzed C-C bond forming hydrogenation.

  2008cited by this paper
• Chiral ammonium betaines: a bifunctional organic base catalyst for asymmetric Mannich-type reaction of alpha-nitrocarboxylates.

  2008cited by this paper
• Catalytic asymmetric allylic and homoallylic diamination of terminal olefins via formal C-H activation.

  2008cited by this paper
• The fluorenone imines of glycine esters and their phosphonic acid analogues.

  2008cited by this paper
• A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids.

  2008cited by this paper
• Dynamic kinetic asymmetric allylic amination and acyl migration of vinyl aziridines with imido carboxylates.

  2007cited by this paper
• The development of scalemic multidentate niobium complexes as catalysts for the highly stereoselective ring opening of meso-epoxides and meso-aziridines.

  2007cited by this paper
• Polishing a diamond in the rough: "Cu--H" catalysis with silanes.

  2007cited by this paper
• Catalytic asymmetric diamination of conjugated dienes and triene.

  2007cited by this paper
• Dinuclear zinc-catalyzed enantioselective Aza-Henry reaction.

  2007cited by this paper
• Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents.

  2007cited by this paper
• Enantioselective iridium-catalyzed imine vinylation: optically enriched allylic amines via alkyne-imine reductive coupling mediated by hydrogen.

  2007cited by this paper
• Hydrogen-mediated reductive coupling of conjugated alkynes with ethyl (N-Sulfinyl)iminoacetates: synthesis of unnatural alpha-amino acids via rhodium-catalyzed C-C bond forming hydrogenation.

  2005cited by this paper
• Highly enantioselective thiourea-catalyzed nitro-Mannich reactions.

  2005cited by this paper
• Nickel-catalyzed reductive cyclizations and couplings.

  2004cited by this paper
• Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral pi-allyl Pd-catalyst.

  2004cited by this paper
• Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

  2004cited by this paper
• Copper(I)-catalyzed asymmetric hydrosilylations of imines at ambient temperatures.

  2004cited by this paper
• Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives.

  2003cited by this paper
• Stereoselective synthesis of trans beta-lactams through iridium-catalyzed reductive coupling of imines and acrylates.

  2002cited by this paper
• The first catalytic asymmetric aza-Henry reaction of nitronates with imines: a novel approach to optically active beta-nitro-alpha-amino acid- and alpha,beta-diamino acid derivatives.

  2001cited by this paper
• The First Catalytic Asymmetric Nitro-Mannich-Type Reaction Promoted by a New Heterobimetallic Complex.

  1999cited by this paper
• The Chemistry of Vicinal Diamines.

  1998cited by this paper

• Preparation of 1,4-Diamines by Enantio- and Diastereoselective Cu-Josiphos-Catalyzed Reductive Couplings of Azatrienes and Imines: Regiodivergence Enabled by Catalyst Structure and Reagent Tailoring.

  2025cites this paper
• Oxidative Kinetic Resolution of Alkyl-Substituted 1,2-Diamines.

  2025cites this paper
• Iridium-Catalyzed Asymmetric β-Selective Hydroamination of Enamides for the Synthesis of 1,2-Diamines.

  2025cites this paper
• Diastereo- and Site-Selective Synthesis of Bishomoallyl Amines by Nickel-Catalyzed Multicomponent Couplings with Imines and Dienes Enabled by a Pyridyl-Phosphine Ligand.

  2025cites this paper
• CuH‐Catalyzed Asymmetric Desymmetrization of Cyclobutenes via Stereodivergent Hydroamination

  2025cites this paper
• Nickel-Catalyzed Alkene–Imine Couplings via Nickelacycles

  2025cites this paper
• Synthesis of gem-Difluorohomoallyl Amines via a Transition-Metal-Free Defluorinative Alkylation of Benzyl Amines with Trifluoromethyl Alkenes.

  2024cites this paper
• Regioselective and Enantioselective Nickel-Catalyzed Intermolecular Reductive Coupling of Aliphatic Alkenes with Imines.

  2024cites this paper
• Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine.

  2024cites this paper
• Palladium-catalyzed enantioselective umpolung allylation of amido-tethered allylic carbonates with isatin-derived ketimines.

  2024cites this paper
• Regio- and Diastereoselective Synthesis of E-Allylic Amines through Hydroalkylation of Terminal Alkynes

  2024cites this paper
• Azocarboxamide-enabled enantioselective regiodivergent unsymmetrical 1,2-diaminations

  2024cites this paper
• Enantioselective Synthesis of Aminals Via Nickel-Catalyzed Hydroamination of 2-Azadienes with Indoles and N-Heterocycles.

  2024cites this paper
• Iron(II)-Catalyzed 1,2-Diamination of Styrenes Installing a Terminal NH2 Group Alongside Unprotected Amines.

  2024cites this paper
• Catalytic asymmetric synthesis of 1,2-diamines.

  2024cites this paper
• Chiral bisphosphine Ph-BPE ligand: a rising star in asymmetric synthesis.

  2024cites this paper
• Intermolecular Hydroalkoxylation and Hydrocarboxylation of 2-Azadienes with High Efficiency.

  2023cites this paper
• Asymmetric alkyl-alkyl cross-coupling enabled by earth-abundant metal-catalyzed hydroalkylations of olefins

  2023cites this paper
• Copper(I)-Catalyzed Asymmetric Allylation of Ketones with 2-Aza-1,4-dienes

  2023cites this paper
• Copper(I)-Catalyzed Asymmetric Allylation of Ketones with 2-Aza-1,4-dienes.

  2023cites this paper
• Nickel-Catalyzed Enantioselective Hydrophosphinylation of 2-Azadienes to Access Enantioenriched α-Aminophosphine Oxides

  2023cites this paper
• Development of regiodivergent asymmetric reductive coupling reactions of allenamides to access heteroatom-rich organic compounds.

  2023cites this paper
• Ligand-Controlled NiH-Catalyzed Regiodivergent and Enantioselective Hydroamination of Alkenyl Amides

  2023cites this paper
• Nickel-Catalyzed Intermolecular Reductive Coupling of Styrene and Its Derivatives with Imines Using Methanol as a Reductant

  2023cites this paper
• Asymmetric Access to Boryl-Substituted Vicinal Aminoalcohols through Cu-Catalyzed Reductive Coupling.

  2023cites this paper
• Catalytic Chemo- and Regioselective Radical Carbocyanation of 2-Azadienes for the Synthesis of α-Amino Nitriles.

  2023cites this paper
• Recent advances in the synthesis of chiral α-tertiary amines via transition-metal catalysis.

  2023cites this paper
• Studies Toward Improved Enantiocontrol in the Asymmetric Cu-Catalyzed Reductive Coupling of Ketones and Allenamides: 1,2-Aminoalcohol Synthesis.

  2023cites this paper
• Catalytic Asymmetric Imine Cross-Coupling Reaction.

  2023cites this paper
• Cobalt-Catalyzed Asymmetric Alkylation of (Hetero)Arenes with Styrenes.

  2022cites this paper
• A Unified Approach to the Aminoallylation of Carbonyl Compounds Through Cu-Catalyzed Enantioselective Reductive Coupling of Alle-namides

  2022cites this paper
• Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer

  2022cites this paper
• Diastereo‐ and Enantioselective Reductive Mannich‐type Reaction of α,β‐Unsaturated Carboxylic Acids to Ketimines: A Direct Entry to Unprotected β 2,3,3‐Amino Acids

  2022cites this paper
• Preparation of Chiral γ-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes.

  2022cites this paper
• Efficient Enantio-, Diastereo, E/Z-, and Site-Selective Nickel-Catalyzed Fragment Couplings of Aldehydes, Dienes, and Organoborons.

  2022cites this paper
• Copper-Catalyzed Asymmetric Conjugate Addition of Alkene-Derived Nucleophiles to Alkenyl-Substituted Heteroarenes

  2022cites this paper
• Copper-Catalyzed Umpolung of N-2,2,2-Trifluoroethylisatin Ketimines for the Enantioselective 1,3-Dipolar Cycloaddition with Benzo[b]thiophene Sulfones.

  2022cites this paper
• α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes

  2022cites this paper
• A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines.

  2021influential citation
• Access to Chiral Diamine Derivatives through Stereoselective Cu-Catalyzed Reductive Coupling of Imines and Allenamides

  2021cites this paper
• Iron-Catalyzed Radical Asymmetric Aminoazidation and Diazidation of Styrenes.

  2021cites this paper
• CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers.

  2021cites this paper
• Synthesis of an elusive, stable 2-azaallyl radical guided by electrochemical and reactivity studies of 2-azaallyl anions

  2021cites this paper
• Tb2(WO4)3@N-GQDs-FA as an efficient nanocatalyst for the efficient synthesis of β-aminoalcohols in aqueous solution

  2021cites this paper
• Nickel-catalyzed enantioselective vinylation of aryl 2-azaallyl anions†‡

  2021cites this paper
• CO2 capture intensified by solvents with metal hydride

  2021cites this paper
• Enantioselective Catalyzed Synthesis of Amino Derivatives Using Electrophilic Open‐Chain N ‐Activated Ketimines

  2021cites this paper
• Transition-Metal-Catalyzed Asymmetric Couplings of α-Aminoalkyl Fragments to Access Chiral Alkylamines

  2021cites this paper
• Synthesis of 1,2-Aminoalcohols through Enantioselective Aminoallylation of Ketones by Cu-Catalyzed Reductive Coupling

  2021cites this paper
• Iron-Catalyzed Intra-intermolecular Aminoazidation of Alkenes

  2020cites this paper
• Formal α-Allylation of Primary Amines by a Dearomative, Palladium-Catalyzed Umpolung Allylation of N-(Aryloxy)imines.

  2020cites this paper
• Cu ‐Catalyzed Asymmetric Synthesis

  2020cites this paper
• Synthesis of chiral anti-1,2-diamine derivatives through copper(I)-catalyzed asymmetric α-addition of ketimines to aldimines

  2020cites this paper
• Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines.

  2020cites this paper
• Regioselective and Stereodivergent Synthesis of Enantiomerically Pure Vic-Diamines from Chiral β-Amino Alcohols with 2-Pyridyl and 6-(2,2′-Bipyridyl) Moieties †

  2020cites this paper
• Recent Developments in C–C Bond Formation Using Catalytic Reductive Coupling Strategies

  2020cites this paper
• Nickel-Catalyzed Regioselective Hydroarylation of Internal Enamides.

  2020cites this paper
• CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition.

  2020cites this paper
• Multi-layer 3D chirality: new synthesis, AIE and computational studies

  2020cites this paper
• KOBut/DMSO-Mediated α-C-H Vinylation of N-Benzyl Ketimines with Acetylene Gas: Stereoselective Synthesis of (E,Z)-2-Azadienes.

  2020cites this paper
• Umpolung of Enamines: An Overview on Strategies and Synthons

  2020cites this paper
• Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes.

  2020cites this paper
• Enantio‐ and Diastereoselective Synthesis of Homopropargyl Amines by Copper‐Catalyzed Coupling of Imines, 1,3‐Enynes, and Diborons

  2020cites this paper
• Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers.

  2019cites this paper
• Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis.

  2019cites this paper
• Copper‐Catalyzed, Enantioselective Hydrofunctionalization of Alkenes

  2019cites this paper
• Access to a Catalytically Generated Umpolung Reagent through the Use of Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral Vicinal Aminoalcohol Synthons

  2019cites this paper
• Catalytic, Enantioselective syn-Diamination of Alkenes.

  2019cites this paper
• Highly Selective and Catalytic Generation of Acyclic Quaternary Carbon Stereocenters via Functionalization of 1,3-Dienes with CO2.

  2019cites this paper
• TBHP/NH4I-mediated Direct N-H Phosphorylation of Imines and Imidates.

  2019cites this paper
• One-Pot Aminoalkylation of Aldehydes: Diastereoselective Synthesis of Vicinal Diamines with Azaarylmethylamines.

  2019cites this paper
• Engaging Aldehydes in CuH-Catalyzed Reductive Coupling Reactions: Stereoselective Allylation with Unactivated 1,3-Diene Pronucleophiles.

  2019cites this paper
• Combining Organocatalysis and Photoredox Catalysis: An Asymmetric Synthesis of Chiral β‐Amino α‐Substituted Tryptamines

  2019cites this paper
• Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: A Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes.

  2019cites this paper
• Direct Conversion of Primary Alcohols to 1,2-Amino Alcohols: Enantioselective Iridium-Catalyzed Carbonyl Reductive Coupling of Phthalimido-Allene via Hydrogen Auto-Transfer.

  2019cites this paper
• Catalytic Asymmetric Synthesis of α-Tetrasubstituted α-Trifluoromethyl Homoallylic Amines by Ir-Catalyzed Umpolung Allylation of Imines.

  2019cites this paper
• Reductive coupling of alkenes with unsaturated imines via a radical pathway

  2019cites this paper
• Regio- and Enantioselective Synthesis of 1,2-Diamine Derivatives by Copper-Catalyzed Hydroamination.

  2019cites this paper
• Copper-Catalyzed Asymmetric Reductive Allylation of Ketones with 1,3-Dienes.

  2019cites this paper
• Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines.

  2019cites this paper
• 2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines

  2019cites this paper
• Intermolecular Metal-Catalyzed Reductive Coupling of Dienes, Allenes, and Enynes with Carbonyl Compounds and Imines.

  2018cites this paper
• CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence.

  2018cites this paper
• Intramolecular Umpolung Allylation of Imines.

  2018cites this paper
• 2-Azaallyl Anions, 2-Azaallyl Cations, 2-Azaallyl Radicals, and Azomethine Ylides.

  2018cites this paper
• A Reverse Polarity Approach to Preparing Chiral Amines through Stereoselective C – C Bond Assembly ”

  2018cites this paper
• Cu-Catalyzed Enantioselective Reductive Coupling of 1,3-Dienes and Aldimines.

  2018cites this paper
• Copper-Catalyzed Synthesis of Chiral 1,2-Diamines

  2018cites this paper
• Lewis Acid Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic N-Sulfonylaziridines.

  2018cites this paper
• Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes

  2018cites this paper
• Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl-Silver Intermediate.

  2018cites this paper
• CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications.

  2018cites this paper
• MIT Open Access Articles CuH-Catalyzed Regio-and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers

  year unknowncites this paper