Copper stimulates growth of human umbilical vein endothelial cells in a vascular endothelial growth factor-independent pathway

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Experimental biology and medicine

• Publication date

  2012-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1258/ebm.2011.011267PMID 22185917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The stimulation of angiogenesis and collagen deposition by copper.

  2010cited by this paper
• Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway.

  2009cited by this paper
• Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes.

  2009cited by this paper
• VEGF receptor switching in heart development and disease.

  2009cited by this paper
• Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms.

  2009cited by this paper
• Copper Regulation of Hypoxia-Inducible Factor-1 Activity

  2009cited by this paper
• Role of copper in angiogenesis and its medicinal implications.

  2009cited by this paper
• Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size.

  2008cited by this paper
• Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration.

  2007cited by this paper
• Role of eNOS phosphorylation at Ser-116 in regulation of eNOS activity in endothelial cells.

  2007cited by this paper
• Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice

  2007cited by this paper
• Copper Binding by Tetrathiomolybdate Attenuates Angiogenesis and Tumor Cell Proliferation through the Inhibition of Superoxide Dismutase 1

  2006cited by this paper
• Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.

  2006cited by this paper
• Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells.

  2006cited by this paper
• Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

  2005cited by this paper
• Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity.

  2005cited by this paper
• Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress*

  2004cited by this paper
• A short-term in vitro gill culture system to study the effects of toxic (copper) and non-toxic (cortisol) stressors on the rainbow trout, Oncorhynchus mykiss (Walbaum).

  2004cited by this paper
• Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α*

  2003cited by this paper
• Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.

  2003cited by this paper
• High flow drives vascular endothelial cell proliferation during flow-induced arterial remodeling associated with the expression of vascular endothelial growth factor.

  2003cited by this paper
• Evidence that nitric oxide regulates cell‐cycle progression in the developing chick neuroepithelium

  2002cited by this paper
• Copper-induced vascular endothelial growth factor expression and wound healing.

  2002cited by this paper
• Role of leukocytes and endothelial cells in the development of angiogenesis in inflammation and wound healing.

  2001cited by this paper
• The response of neurones and glial cells to elevated copper.

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein

  2000cited by this paper
• Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity.

  1999cited by this paper
• Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

  1998cited by this paper
• Copper stimulates proliferation of human endothelial cells under culture

  1998cited by this paper
• Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.

  1998cited by this paper

• Construction of a Ti2Cu precipitate layer by laser surface treatment to endow Ti-13Nb-13Zr-5Cu alloy with low elastic modulus and strong antibacterial property

  2025cites this paper
• The Yin and Yang of copper in cardiovascular health and disease

  2025cites this paper
• Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications

  2025cites this paper
• Copper ions-photo dual-crosslinked alginate hydrogel for angiogenesis and osteogenesis.

  2024cites this paper
• A spotlight on the role of copper in the epithelial to mesenchymal transition.

  2024cites this paper
• Reversal of atherosclerosis by restoration of vascular copper homeostasis

  2024cites this paper
• Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge

  2024cites this paper
• Meta-analysis of the Relationship Between Zinc and Copper in Patients with Osteoarthritis

  2024cites this paper
• Bioglass and hybrid bioactive material: A review on the fabrication, therapeutic potential and applications in wound healing

  2024cites this paper
• Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocomposites

  2024cites this paper
• Cuproptosis and copper deficiency in ischemic vascular injury and repair

  2024cites this paper
• Rebuilding the myocardial microenvironment to enhance mesenchymal stem cells-mediated regeneration in ischemic heart disease

  2024cites this paper
• Antibacterial nanofibrous wound dressing mats made from blended chitosan-copper complexes and polyvinyl alcohol (PVA) using electrospinning

  2024cites this paper
• Transition metals in angiogenesis – A narrative review

  2023influential citation
• Cu-doped bioactive glass with enhanced in vitro bioactivity and antibacterial properties

  2023cites this paper
• Enhanced antibacterial activity, corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification

  2023cites this paper
• Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1

  2022cites this paper
• The Oncopig as an Emerging Model to Investigate Copper Regulation in Cancer

  2022cites this paper
• Combined Effects of Polydopamine-Assisted Copper Immobilization on 3D-Printed Porous Ti6Al4V Scaffold for Angiogenic and Osteogenic Bone Regeneration

  2022cites this paper
• A high-hydrophilic Cu2O-TiO2/Ti2O3/TiO coating on Ti-5Cu alloy: Perfect antibacterial property and rapid endothelialization potential.

  2022cites this paper
• Nanobiotechnology: Applications in Chronic Wound Healing

  2022cites this paper
• Synergy effects of copper and L-arginine on osteogenic, angiogenic, and antibacterial activities.

  2022cites this paper
• Facile fabrication of biodegradable endothelium-mimicking coatings on bioabsorbable zinc-alloy stents by one-step electrophoretic deposition.

  2022cites this paper
• Copper-Loaded Biodegradable Bone Wax with Antibacterial and Angiogenic Properties in Early Bone Repair.

  2021cites this paper
• Multifunctional TaCu-nanotubes coated titanium for enhanced bacteriostatic, angiogenic and osteogenic properties.

  2021cites this paper
• Assessing the potential role of copper and cobalt in stimulating angiogenesis for tissue regeneration

  2021cites this paper
• Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants

  2021cites this paper
• Improvement in antibacterial ability and cell cytotoxicity of Ti–Cu alloy by anodic oxidation

  2021cites this paper
• Copper-based biomaterials for bone and cartilage tissue engineering

  2021cites this paper
• Copper Preserves Vasculature Structure and Function by Protecting Endothelial Cells from Apoptosis in Ischemic Myocardium

  2021cites this paper
• Induced Biological Response in Contact with Ag-and Cu-Doped Carbon Coatings for Potential Orthopedic Applications

  2021cites this paper
• The Immunomodulatory Potential of Copper and Silver Based Self-Assembled Metal Organic Biohybrids Nanomaterials in Cancer Theranostics

  2021cites this paper
• Reactive magnetron co-sputtering of Ti-xCuO coatings: Multifunctional interfaces for blood-contacting devices.

  2020cites this paper
• Copper promotes the migration of bone marrow mesenchymal stem cells via Rnd3‐dependent cytoskeleton remodeling

  2020cites this paper
• Copper promotion of myocardial regeneration

  2020cites this paper
• Repair of segmental rabbit radial defects with Cu/Zn co-doped calcium phosphate scaffolds incorporating GDF-5 carrier

  2020cites this paper
• A potential strategy for in-stent restenosis: Inhibition of migration and proliferation of vascular smooth muscle cells by Cu ion.

  2020cites this paper
• Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

  2020cites this paper
• Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing.

  2020cites this paper
• A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

  2020cites this paper
• Copper-containing bioactive glasses and glass-ceramics: From tissue regeneration to cancer therapeutic strategies.

  2020cites this paper
• Antibacterial, proangiogenic, and osteopromotive nanoglass paste coordinates regenerative process following bacterial infection in hard tissue.

  2020cites this paper
• Concentration-dependent osteogenic and angiogenic biological performances of calcium phosphate cement modified with copper ions.

  2019cites this paper
• Multifunctional Ti-xCu coatings for cardiovascular interfaces: Control of microstructure and surface chemistry.

  2019cites this paper
• Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

  2019cites this paper
• Synergistic Effects of N/Cu Dual Ions Implantation on Stimulating Antibacterial Ability and Angiogenic Activity of Titanium.

  2018cites this paper
• Pro-angiogenic near infrared-responsive hydrogels for deliberate transgene expression.

  2018cites this paper
• Synthesis, structure and in vitro antiproliferative activities of oxamido‐bridged dicopper(II) complexes: A comparative study of experimental evidence and molecular docking of DNA/protein binding

  2018cites this paper
• Physical and Biological Properties of Cobalt- and Copper-Doped Calcium Phosphates as Bone Substitute Materials

  2018cites this paper
• Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies

  2017cites this paper
• Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells

  2017cites this paper
• Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression

  2017cites this paper
• Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing.

  2017cites this paper
• Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties

  2017cites this paper
• The Inorganic Perspective of VEGF: Interactions of Cu(2+) with Peptides Encompassing a Recognition Domain of the VEGF Receptor.

  2016cites this paper
• Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A

  2016cites this paper
• Preparation and in vitro osteogenic, angiogenic and antibacterial properties of cuprorivaite (CaCuSi4O10, Cup) bioceramics

  2016cites this paper
• Evaluation of in vivo angiogenetic effects of copper doped bioactive glass scaffolds in the AV loop model

  2016influential citation
• Determination of copper in composite biomaterials by capillary electrophoresis: an UV-direct method based on in situ complex formation

  2016cites this paper
• Biosynthesis of copper nanoparticles using copper-resistant Bacillus cereus, a soil isolate

  2016cites this paper
• Nanocomposite scaffolds with tunable mechanical and degradation capabilities: co-delivery of bioactive agents for bone tissue engineering

  2016cites this paper
• Three-dimensional endothelial cell morphogenesis under controlled ion release from copper-doped phosphate glass.

  2015influential citation
• Effect of ion release from Cu-doped 45S5 Bioglass® on 3D endothelial cell morphogenesis.

  2015cites this paper
• Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

  2015cites this paper
• A dual function of copper in designing regenerative implants.

  2015cites this paper
• Role of copper in regression of cardiac hypertrophy.

  2015cites this paper
• Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

  2015cites this paper
• Bioactive Copper-Doped Glass Scaffolds Can Stimulate Endothelial Cells in Co-Culture in Combination with Mesenchymal Stem Cells

  2014cites this paper
• Copper promotion of angiogenesis in isolated rat aortic ring: role of vascular endothelial growth factor.

  2014influential citation
• Inhibition of osteogenic differentiation of mesenchymal stem cells by copper supplementation

  2014cites this paper
• Cuprous oxide nanoparticles inhibit angiogenesis via down regulation of VEGFR2 expression.

  2014cites this paper
• Synergy effects of copper and silicon ions on stimulation of vascularization by copper-doped calcium silicate.

  2014cites this paper
• Role of Copper and Vascular Endothelial Growth Factor (VEGF) on Endometrial Angiogenesis

  2013cites this paper
• Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: synthesis, characterization, magnetic properties, and biological activity.

  2013cites this paper
• Controlled Copper Ion Release from Phosphate-Based Glasses Improves Human Umbilical Vein Endothelial Cell Survival in a Reduced Nutrient Environment

  2012cites this paper
• Copper Is Required for Cobalt-Induced Transcriptional Activity of Hypoxia-Inducible Factor-1

  2012cites this paper