Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Endocrinology

• Publication date

  2011-05-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2011-0036PMID 21586553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability.

  2010cited by this paper
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  2010influential reference
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  2007cited by this paper
• Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages.

  2007cited by this paper
• Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice.

  2007cited by this paper
• A Substrate Specificity-determining Unit of Three Lin12-Notch Repeat Modules Is Formed in Trans within the Pappalysin-1 Dimer and Requires a Sequence Stretch C-terminal to the Third Module*

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• Genetic Deletion of Pregnancy-Associated Plasma Protein-A Is Associated With Resistance to Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice Challenged With a High-Fat Diet

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• Impact of Pregnancy‐Associated Plasma Protein‐A Deletion on the Adult Murine Skeleton

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  2006cited by this paper
• Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury.

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• Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo.

  2006cited by this paper
• Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module.

  2004cited by this paper
• Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development

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  2003cited by this paper
• Transforming Growth Factor‐β Regulation of the Insulin‐Like Growth Factor Binding Protein‐4 Protease System in Cultured Human Osteoblasts

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• Development: Early-pregnancy origins of low birth weight

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• Cell Surface Targeting of Pregnancy-associated Plasma Protein A Proteolytic Activity

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  2002cited by this paper
• Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane.

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• Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth.

  2002cited by this paper
• Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse.

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• Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.

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  1999cited by this paper
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  1998cited by this paper
• Characterization of four human pregnancy-associated plasma proteins.

  1974cited by this paper

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• Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances.

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• Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

  2024cites this paper
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• The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story.

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition

  2023cites this paper
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  2023cites this paper
• The History of the Insulin-Like Growth Factor System

  2022cites this paper
• The Genomic Consistency of the Loss of Anadromy in an Arctic Fish (Salvelinus alpinus)

  2022cites this paper
• Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency

  2021cites this paper
• Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease

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