A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).

No abstract is available for this paper.

• Publication year

  2014

• Venue

  International Journal of Molecular Medicine

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijmm.2013.1592PMID 24356923
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.

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• Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008).

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• Ageing in Werner syndrome.

  2012cited by this paper
• RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

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• The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity.

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• Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome.

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• RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress

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• Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

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• Axis of ageing: telomeres, p53 and mitochondria

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• Accelerated in vivo epidermal telomere loss in Werner syndrome

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• Shelterin complex and associated factors at human telomeres

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• Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review).

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• Telomere dysfunction induces metabolic and mitochondrial compromise

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• Aging and TOR: interwoven in the fabric of life

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• Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

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• Vitamin C restores healthy aging in a mouse model for Werner syndrome

  2010cited by this paper
• Letter to the editor: periodontal conditions in Werner syndrome.

  2010cited by this paper
• TP53 and MTOR crosstalk to regulate cellular senescence

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• Growth and aging: a common molecular mechanism

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• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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• Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells

  2008cited by this paper
• Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?

  2008cited by this paper
• Syndrome-causing mutations in Werner syndrome.

  2008cited by this paper
• Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance.

  2008cited by this paper
• How shelterin protects mammalian telomeres.

  2008cited by this paper
• The Role of Cellular Senescence in Werner Syndrome

  2007cited by this paper
• Telomere dysfunction as a cause of genomic instability in Werner syndrome

  2007cited by this paper
• TOR signaling in growth and metabolism.

  2006cited by this paper
• Multiple Involvement of Oxidative Stress in Werner Syndrome Phenotype

  2005cited by this paper
• Current advances in unraveling the function of the Werner syndrome protein.

  2005cited by this paper
• Shelterin: the protein complex that shapes and safeguards human telomeres.

  2005cited by this paper
• Telomeres, crisis and cancer.

  2005cited by this paper
• In vivo prooxidant state in Werner syndrome (WS): Results from three WS patients and two WS heterozygotes

  2005cited by this paper
• Essential role of limiting telomeres in the pathogenesis of Werner syndrome

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• Steps Involved in Immortalization and Tumorigenesis in Human B-Lymphoblastoid Cell Lines Transformed by Epstein-Barr Virus

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• Molecular biology of Werner syndrome

  2004cited by this paper
• WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus.

  2004cited by this paper
• Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

  2004cited by this paper
• Investigation of the Signaling Pathways Involved in the Proliferative Life Span Barriers in Werner Syndrome Fibroblasts

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• Telomeres, stem cells, senescence, and cancer.

  2004cited by this paper
• WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex

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• CANCER PATHOGENESIS IN THE HUMAN RecQ HELICASE DEFICIENCY SYNDROMES

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• From premature gray hair to helicase - werner syndrome : implications for aging and cancer

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• Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.

  2000cited by this paper
• Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

  1999cited by this paper
• Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.

  1999cited by this paper
• Incorrect us of "immortalization" for B-lymphoblastoid cell lines transformed by Epstein-Barr virus.

  1999cited by this paper
• Incorrect Use of “Immortalization” for B-Lymphoblastoid Cell Lines Transformed by Epstein-Barr Virus

  1999cited by this paper
• Immunological diagnosis of Werner syndrome by down-regulated and truncated gene products

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• Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG) n *

  1999cited by this paper
• Reconsideration of senescence, immortalization and telomere maintenance of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines.

  1999cited by this paper
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• A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.

  1998cited by this paper
• Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients.

  1998cited by this paper
• Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.

  1998cited by this paper
• The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

  1998cited by this paper
• De novo telomere addition by Tetrahymena telomerase in vitro

  1997cited by this paper
• Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus

  1997cited by this paper
• DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.

  1997cited by this paper
• Telomere crisis, the driving force in cancer cell evolution.

  1997cited by this paper
• Analysis of helicase gene mutations in Japanese Werner’s syndrome patients

  1997cited by this paper
• Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

  1997cited by this paper
• Impaired nuclear localization of defective DNA helicases in Werner's syndrome

  1997cited by this paper
• Positional Cloning of the Werner's Syndrome Gene

  1996cited by this paper
• Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

  1996cited by this paper
• Excess of rare cancers in Werner syndrome (adult progeria).

  1996cited by this paper
• The Bloom's syndrome gene product is homologous to RecQ helicases.

  1995cited by this paper
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  1994cited by this paper
• Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12.

  1994cited by this paper
• Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines.

  1992cited by this paper
• Genetic linkage of Werner's syndrome to five markers on chromosome 8

  1992cited by this paper
• Mutator phenotype of Werner syndrome is characterized by extensive deletions.

  1989cited by this paper
• Spontaneous and induced chromosomal instability in Werner syndrome

  1988cited by this paper
• Clinical, demographic, and genetic aspects of the Werner syndrome in Japan.

  1985cited by this paper
• Autoradiographic studies of DNA replication in Werner's syndrome cells.

  1985cited by this paper
• Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism.

  1981cited by this paper
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• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

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• Diagnosis and Management of Hereditary Sarcoma.

  2016cites this paper
• Interventions for preventing keratinocyte cancer in high-risk groups not receiving immunosuppressive therapy

  2016cites this paper
• RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers

  2015cites this paper
• Biomathematical exploration of the MARK-AGE database

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