Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Circulation Research

• Publication date

  2015-07-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.117.306712PMID 26034040PMCID PMC4490945
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

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• The PRMT-mediated arginine methylation: From molecular mechanisms to therapeutic targets in cardiovascular diseases.

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• Wnt/β‐catenin signaling: Structure, assembly and endocytosis of the signalosome

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• Aldosterone is a possible new stimulating factor for promoting vascular calcification.

  2021cites this paper
• Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Pathology of metabolically-related dyslipidemia.

  2021cites this paper
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  2021influential citation
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  2021cites this paper
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  2021influential citation
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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