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Tau PET distributional pattern in AD patients with visuospatial dysfunction.

Xi Sun,B. Nie,Shujun Zhao,Qian Chen,Panlong Li,Tianhao Zhang,Tingting Pan,Ting Feng,Luying Wang,Xiaolong Yin,Wei Zhang,Shilun Zhao,B. Shan,Hua Liu,S. Liang,L. Ai,Guihong Wang

Published 2019 in Current Alzheimer Research

ABSTRACT

BACKGROUND Visuospatial dysfunction is one predominant symptom in many atypical Alzheimer's disease (AD) patients, however, until now its neural correlates still remain unclear. For the accumulation of intracellular hyperphosphorylated tau proteins is a major pathogenic factor in neurodegeneration of AD, the distributional pattern of tau could highlight the affected brain regions associated with specific cognitive deficits. OBJECTIVE We investigated the brain regions particularly affected by tau accumulation in patients with visuospatial dysfunction to explore its neural correlates. METHOD Using 18F-AV-1451 tau positron emission tomography (PET), voxel-wise two-sample t-tests were performed between AD patients with obvious visuospatial dysfunction (VS-AD) and cognitively normal subjects, AD patients with little-to-no visuospatial dysfunction (non VS-AD) and cognitively normal subjects, respectively. RESULTS Results showed increased tau accumulations mainly located in occipitoparietal cortex, posterior cingulate cortex, precuneus, inferior and medial temporal cortex in VS-AD patients, while increased tau accumulations mainly occurred in the inferior and medial temporal cortex in non VS-AD patients. CONCLUSION These findings suggested that occipitoparietal cortex, posterior cingulate cortex and precuneus, which were particularly affected by increased tau accumulation in VS-AD patients, may associate with visuospatial dysfunction of AD.

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