Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix®) injections versus local anesthetic in osteoarthritis of the hip

IntroductionComparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix®) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip.MethodsA pilot prospective, double-blind, 6-month randomized trial of 42 patients with hip OA. HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety.ResultsPatients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (P < 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (P < 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal.ConclusionsThis comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA.Trial registration numberISRCTN39397064.

• Publication year

  2009

• Venue

  Arthritis Research & Therapy

• Publication date

  2009-12-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/ar2875PMID 20003205PMCID 3003515
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [18-month observational study on efficacy of intraarticular hyaluronic acid (Hylan G-F 20) injections under ultrasound guidance in hip osteoarthritis].

  2011cited by this paper
• [Safety profile of 185 ultrasound-guided intra-articular injections for treatment of rheumatic diseases of the hip].

  2011cited by this paper
• OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009.

  2010cited by this paper
• What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature

  2008cited by this paper
• OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.

  2008cited by this paper
• The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty.

  2007cited by this paper
• Cardiovascular Thromboembolic Adverse Effects Associated with Cyclooxygenase-2 Selective Inhibitors and Nonselective Antiinflammatory Drugs

  2007cited by this paper
• Risk of upper gastrointestinal events with the use of various NSAIDs: A case-control study in a general population

  2007cited by this paper
• Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline.

  2006cited by this paper
• Intraarticular corticosteroid for treatment of osteoarthritis of the knee.

  2006cited by this paper
• Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review.

  2006cited by this paper
• Safety and efficacy of ultrasound-guided intra-articular hylan G-F 20 injection in osteoarthritis of the hip: a pilot study

  2005cited by this paper
• Is there evidence to support the inclusion of viscosupplementation in the treatment paradigm for patients with hip osteoarthritis?

  2005cited by this paper
• Open pilot study of ultrasound-guided intra-articular injection of hylan G-F 20 (Synvisc) in the treatment of symptomatic hip osteoarthritis

  2005cited by this paper
• Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis

  2005cited by this paper
• Intraarticular corticosteroid for treatment of osteoarthritis of the knee.

  2005cited by this paper
• Accuracy and Outcome of Sonographically Guided Intra‐articular Sodium Hyaluronate Injections in Patients With Osteoarthritis of the Hip

  2005cited by this paper
• Hyaluronic acid injections for knee osteoarthritis. Systematic review of the literature.

  2004cited by this paper
• Cardiovascular and renovascular implications of COX-2 inhibition.

  2004cited by this paper
• OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.

  2004cited by this paper
• Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

  2003cited by this paper
• Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study.

  2003influential reference
• Role of hylan G-F 20 in treatment of osteoarthritis of the hip joint.

  2003cited by this paper
• Efficacy and safety of viscosupplementation by ultrasound-guided intra-articular injection in osteoarthritis of the hip.

  2003influential reference
• Hip osteoarthritis: short-term efficacy and safety of viscosupplementation by hylan G-F 20. An open-label study in 22 patients.

  2002cited by this paper
• A systematic review of the literature

  2002cited by this paper
• Guidance by ultrasound of intra-articular injections in the knee and hip joints.

  2001cited by this paper
• Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines.

  2000cited by this paper
• Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update

  2000cited by this paper
• Screening for adverse events.

  1999influential reference
• Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip.

  1998cited by this paper
• Diagnostic value of intra-articular anaesthetic in primary osteoarthritis of the hip.

  1998cited by this paper
• Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group.

  1998cited by this paper
• Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States.

  1998influential reference
• The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone.

  1995cited by this paper
• The value of bupivicaine hip injection in the differentiation of coxarthrosis from lower extremity neuropathy.

  1991cited by this paper
• Osteoarthritis prevalence in adults by age, sex, race, and geographic area.

  1966cited by this paper

• Long-term efficacy of intra-articular viscosupplementation in delaying hip osteoarthritis radiographic progression: a retrospective, non-controlled study from the ANTIAGE registry.

  2026cites this paper
• Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of osteoarthritis of the hip, 2024- the third edition- secondary publication.

  2025cites this paper
• Intra-articular hyaluronic acid injections for hip osteoarthritis: a level I systematic review

  2025cites this paper
• Advances in hyaluronic acid hydrogel for meniscus repair

  2025cites this paper
• Effectiveness of ultrasound-guided hip injections on pain and functioning in patients with hip osteoarthritis: A systematic review

  2025influential citation
• 10 years of real-world data: long-term efficacy and safety of HyalOne® for hip osteoarthritis

  2025cites this paper
• Clinical efficacy of multiple intra-articular injection for hip osteoarthritis.

  2024cites this paper
• Ultrasound-guided intra-articular hyaluronic acid injection in hip osteoarthritis

  2023cites this paper
• Osteoarthritis of the hip joints: possibilities of local therapy

  2023cites this paper
• Viscosupplementation is Effective for the Treatment of Osteoarthritis in the Hip. A Systematic Review.

  2023cites this paper
• Comparison of Various Modalities in the Treatment of Early Knee Osteoarthritis: An Unsolved Controversy

  2023cites this paper
• BRAZILIAN CONSENSUS STATEMENT ON VISCOSUPPLEMENTATION OF THE HIP (COBRAVI-Q)

  2022cites this paper
• The Booster Effect of a Single Quarterly Dose of Hyaluronic Acid in Knee Osteoarthritis: Five-Year Results of a Registry-Based Study

  2022cites this paper
• Diclofenac–hyaluronate conjugate (diclofenac etalhyaluronate) intra-articular injection for hip, ankle, shoulder, and elbow osteoarthritis: a randomized controlled trial

  2022cites this paper
• Ultrasound-guided injection with hyaluronic acid in hip osteoarthritis: efficacy and safety in a real-life setting

  2022cites this paper
• Cartilage Lesions and Osteoarthritis of the Hip and Ankle: Orthobiologics

  2022cites this paper
• Molecular Weight of Hyaluronic Acid Has Major Influence on Its Efficacy and Safety for Viscosupplementation in Hip Osteoarthritis: A Systematic Review and Meta-Analysis

  2021cites this paper
• The use of biologics to improve patient-reported outcomes in hip preservation

  2021cites this paper
• The Use of Biologics for Hip Preservation

  2021cites this paper
• Hyaluronan and Derivatives: An In Vitro Multilevel Assessment of Their Potential in Viscosupplementation

  2021cites this paper
• Viscosupplementation for hip osteoarthritis: Does systematic review of patient-reported outcome measures support use?

  2020cites this paper
• Different Intra-articular Injections as Therapy for Hip Osteoarthritis: A Systematic Review and Network Meta-analysis.

  2020cites this paper
• Efficacy of a Single Intra-Articular HYMOVIS ONE Injection for Managing Symptomatic Hip Osteoarthritis: A 12-Month Follow-Up Retrospective Analysis of the ANTIAGE Register Data

  2020cites this paper
• Predictors of efficacy of viscosupplementation for the treatment of hip osteoarthritis: a retrospective cohort study

  2020cites this paper
• Efficacy and safety of viscosupplementation with hyaluronic acid for hip osteoarthritis: results from a cross-sectional study with a minimum follow-up of 4 years

  2020cites this paper
• Intra-articular hyaluronic acid

  2020cites this paper
• Injection therapy in hip osteoarthritis: one year in review

  2020cites this paper
• Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain: a systematic review and network meta-analysis of randomised controlled trials

  2020cites this paper
• Adjuvant Therapies in the Treatment of Pre-Arthritic Hip Disease

  2020cites this paper
• Place des gestes intra articulaires dans la coxarthrose ?

  2019cites this paper
• Intra-Articular Viscosupplementation for Patients with Hip Osteoarthritis: A Meta-Analysis and Systematic Review

  2019influential citation
• Hyaluronic Acid Derivatives for Translational Medicines.

  2019cites this paper
• Sodium Hyaluronate (for Louisiana Only) – Community Plan Medical Benefit Drug Policy

  2019cites this paper
• High Molecular Weight Hyaluronic Acid (Hyalubrix/HyalOne) for Treating Symptomatic Hip Osteoarthritis

  2019cites this paper
• SODIUM HYALURONATE ( FOR TENNESSEE ONLY )

  2019cites this paper
• Biologics in hip preservation

  2018cites this paper
• Recent advances in hyaluronic acid based therapy for osteoarthritis

  2018cites this paper
• When is indicated viscosupplementation in hip osteoarthritis?

  2018cites this paper
• Hyaluronic acid injections in musculoskeletal disorders guidelines

  2018cites this paper
• Chondroprotection Validation

  2018cites this paper
• Efficacy of intra-articular hyaluronic acid injections in hip osteoarthritis: a meta-analysis of randomized controlled trials

  2017influential citation
• Treatment Options for Degenerative Joint Disease of the Hip

  2017cites this paper
• Nonsurgical Treatment (Indications, Limitations, Outcomes): Injections

  2017cites this paper
• HyalOne® in the treatment of symptomatic hip OA - data from the ANTIAGE register: seven years of observation.

  2017cites this paper
• Viscosupplementation for Hip Osteoarthritis: A Systematic Review and Meta-Analysis of the Efficacy on Pain and Disability, and the Occurrence of Adverse Events.

  2017cites this paper
• Intra-articular therapy in hip osteoarthritis Mini-review

  2017cites this paper
• Intra-articular therapy in hip osteoarthritis.

  2017cites this paper
• Combination , for Hip Osteoarthritis : A Randomized Controlled Study Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid , Separately and in

  2016cites this paper
• Differences Regarding Branded HA in Italy, Part 2: Data from Clinical Studies on Knee, Hip, Shoulder, Ankle, Temporomandibular Joint, Vertebral Facets, and Carpometacarpal Joint

  2016cites this paper
• Viscosupplementation with intra-articular hyaluronic acid for hip disorders. A systematic review and meta-analysis.

  2016cites this paper
• Interventional MSK procedures: the hip.

  2016cites this paper
• PRP and HA for Hip Osteoarthritis: Letter to the Editor

  2016cites this paper
• Managing Osteoarthritis and Other Chronic Musculoskeletal Pain Disorders.

  2016cites this paper
• Infiltrative Therapy as Conservative Treatment in HIP Osteoarthritis: A Literature Review

  2016cites this paper
• PRP and HA for Hip Osteoarthritis: Response

  2016cites this paper
• Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis

  2016cites this paper
• Hyaluronic Acid Injections in Patients with Hip Osteoarthritis: A Systematic Review

  2016influential citation
• Groin pain syndrome: an association of different pathologies and a case presentation.

  2015cites this paper
• Human Infrapatellar Fat Pad-Derived Stromal Cells have more Potent Differentiation Capacity than other Mesenchymal Cells and can be Enhanced by Hyaluronan

  2015cites this paper
• Ultrasound-Guided Interventional Maneuvers

  2015cites this paper
• Single intra-articular injection of high molecular weight hyaluronic acid for hip osteoarthritis

  2015cites this paper
• INTERVENTIONAL MSK PROCEDURES SPECIAL FEATURE: REVIEW ARTICLE Interventional MSK procedures: the hip

  2015cites this paper
• Is intra-articular hyaluronic acid effective in treating osteoarthritis of the hip joint?

  2015influential citation
• The Non-operative Management of Hip Disease in Young Adults

  2014cites this paper
• Economic impact of the use of Hyalubrix® in the treatment of hip osteoarthritis in Italy

  2014cites this paper
• Ultrasound-guided procedures around the wrist and hand: how to do.

  2014cites this paper
• Viscosupplementation with high molecular weight native hyaluronan. Focus on a 1500-2000 KDa fraction (Hyalubrix®).

  2014cites this paper
• The athlete's hip and groin.

  2013cites this paper
• Ultrasound-Guided Interventional Procedures in Pain Medicine: A Review of Anatomy, Sonoanatomy, and Procedures. Part IV: Hip

  2013cites this paper
• Ultrasound (US) guided interventional procedures around the hand and the wrist.

  2013cites this paper
• Musculoskeletal ultrasound guiding shoulder injection when "one picture is worth ten thousand landmarks".

  2013cites this paper
• Ultrasound in Athletes: Emerging Techniques in Point-of-Care Practice

  2012cites this paper
• Viscosupplementation in haemophilic arthropathy: a long‐term follow‐up study

  2012cites this paper
• Sport et vieillissement articulaire avec arthrose précoce et conflit antérieur de hanche

  2012cites this paper
• Sodium Hyaluronate

  2012cites this paper
• Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

  2012cites this paper
• Total hip replacement rate in a cohort of patients affected by symptomatic hip osteoarthritis following intra-articular sodium hyaluronate (MW 1,500–2,000 kDa) ORTOBRIX study

  2012cites this paper
• Kinematic and kinetic modifications in walking pattern of hip osteoarthritis patients induced by intra-articular injections of hyaluronic acid.

  2012cites this paper
• Hip arthroscopy for femoroacetabular impingement in patients aged 50 years or older.

  2012cites this paper
• Hyaluronic Acid for the Treatment of Osteoarthritis in all Joints Except the Knee

  2012cites this paper
• Non-surgical treatment of osteoarthritis-related pain in the elderly

  2011cites this paper
• L’arthrose : une nouvelle maladie inflammatoire ? Actualités fondamentales et thérapeutiques

  2011cites this paper
• "Ultrasound, if performed by skilled professionals, has become the most commonly used guidance technique for reasons of cost-effectiveness, availability, real-time imaging capability and ease to use."

  2011cites this paper
• Ultrasound-guided joint injection in difficult locations

  2011cites this paper
• Cartilage Injuries in the Degenerative Hip

  2011cites this paper
• Power Doppler Sonography and Clinical Monitoring for Hyaluronic Acid Treatment of Rhizarthrosis: A Pilot Study

  2011cites this paper
• Recent clinical evidence for the treatment of osteoarthritis: what we have learned.

  2011cites this paper
• Use of Viscosupplementation for Knee Osteoarthritis: An Update

  2011cites this paper
• Intra-articular injection of hyaluronic acid (MW 1,500–2,000 kDa; HyalOne®) in symptomatic osteoarthritis of the hip: a prospective cohort study

  2011cites this paper
• Hylan G-F 20 Improves Hip Osteoarthritis: A Prospective, Randomized Study

  2010cites this paper
• PATIENT PREFERENCE AND ADHERENCE

  year unknowncites this paper
• Reumatismo - The Italian Journal of Rheumatology

  year unknowncites this paper