Asthma and Invasive Pneumococcal Disease in the Age of Pneumococcal Conjugate Vaccines

T. Tan

Published 2019 in Pediatrics

ABSTRACT

* Abbreviations: CDC — : Centers for Disease Control and Prevention IPD — : invasive pneumococcal disease PCV — : pneumococcal conjugate vaccine The widespread use of pneumococcal conjugate vaccines (PCVs) in the United States has led to a significant decrease in invasive pneumococcal disease (IPD) and pneumonia in the pediatric population. On the basis of data reported by the Centers for Disease Control and Prevention (CDC), the overall incidence of IPD among children <5 years of age in the United States decreased from 95 cases per 100 000 in 1998 to 9 cases per 100 000 in 2016, and, similarly, the incidence of IPD caused by 13-valent PCV serotypes decreased from 88 cases per 100 000 in 1998 to 2 cases per 100 000 in 2016.1,2 However, IPD still remains a leading cause of morbidity and mortality in the United States and worldwide. In 2017, … Address correspondence to Tina Q. Tan, MD, Infectious Diseases Division, Department of Pediatrics, Ann and Robert H. Lurie Children’s Hospital of Chicago, 225 E Chicago Ave, Box 20, Chicago, IL 60611. E-mail: titan{at}luriechildrens.org

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