Milk Consumption Decreases Risk for Breast Cancer in Korean Women under 50 Years of Age: Results from the Health Examinees Study

Epidemiologic studies regarding breast cancer risk related to milk consumption remain controversial. The aim of this study was to evaluate the association between milk consumption and the risk for breast cancer. A total of 93,306 participants, aged 40–69 years, were included in the prospective cohort study in the Health Examinees-Gem (HEXA-G) study between 2004 and 2013. Dietary intake was assessed using a validated food frequency questionnaire. Information on cancer diagnosis in the eligible cohort was retrieved from the Korea Central Cancer Registry through 31 December 2014. The Cox proportional hazards model was used to estimate multivariate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 359 breast cancer cases were observed over a median follow-up period of 6.3 years. Milk consumption was not associated with decreased risk for breast cancer in the total population (p for trend = 0.0687). In women under 50 years of age, however, milk consumption was inversely associated with breast cancer risk. In the comparison between highest (≥1 serving/day) and lowest (<1 serving/week) intake categories of milk, the multivariate HR (95% CI) was 0.58 (0.35–0.97, p for trend = 0.0195)) among women under 50 years of age. In conclusion, our findings show that milk consumption in Korean women aged 50 or younger is associated with a decreased risk for breast cancer, when compared to those who never or rarely consumed milk. Further studies need to be conducted to assess this relationship and confirm these results.

• Publication year

  2019

• Venue

  Nutrients

• Publication date

  2019-12-21

• Fields of study

  Agricultural and Food Sciences, Medicine

• Identifiers
  DOI 10.3390/nu12010032PMID 31877693PMCID 7019619
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Milk and yogurt intake and breast cancer risk

  2019cited by this paper
• Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015

  2018cited by this paper
• Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

  2018influential reference
• Egg Consumption and Risk of Metabolic Syndrome in Korean Adults: Results from the Health Examinees Study

  2017cited by this paper
• Cohort Profile Cohort Profile : The Korean Genome and Epidemiology Study ( KoGES ) Consortium

  2017cited by this paper
• The Association between Dairy Intake and Breast Cancer in Western and Asian Populations: A Systematic Review and Meta-Analysis

  2015cited by this paper
• The Health Examinees (HEXA) study: rationale, study design and baseline characteristics.

  2015cited by this paper
• Consumption of dairy and meat in relation to breast cancer risk in the Black Women’s Health Study

  2013cited by this paper
• Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010

  2013cited by this paper
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

  2012cited by this paper
• Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies

  2011cited by this paper
• Alcohol consumption and ethyl carbamate.

  2010cited by this paper
• Dietary patterns and breast cancer risk among Chinese women

  2010cited by this paper
• Dairy consumption and calcium intake and risk of breast cancer in a prospective cohort: The Norwegian Women and Cancer study

  2010cited by this paper
• Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohort.

  2007cited by this paper
• Meat consumption and risk of breast cancer in the UK Women's Cohort Study

  2007cited by this paper
• Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study

  2007influential reference
• Dairy Products, Calcium and the Risk of Breast Cancer: Results of the French SU.VI.MAX Prospective Study

  2007influential reference
• Intakes of calcium and vitamin D and breast cancer risk in women.

  2006cited by this paper
• Dairy products and breast cancer risk: a review of the literature.

  2005cited by this paper
• Dairy, Calcium, and Vitamin D Intake and Postmenopausal Breast Cancer Risk in the Cancer Prevention Study II Nutrition Cohort

  2005cited by this paper
• Breast cancer and hormone-replacement therapy in the Million Women Study.

  2003cited by this paper
• Breast cancer and hormone-replacement therapy: the Million Women Study.

  2003cited by this paper
• Premenopausal fat intake and risk of breast cancer.

  2003cited by this paper
• Breast cancer and hormone-replacement therapy in the Million Women Study.

  2003cited by this paper
• Development of a Semi-quantitative Food Frequency Questionnaire Based on Dietary Data from the Korea National Health and Nutrition Examination Survey

  2003cited by this paper
• Dairy foods and risk of breast cancer: a case–control study in Montevideo, Uruguay

  2002cited by this paper
• Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies.

  2002cited by this paper
• Intake of dairy products, calcium, and vitamin d and risk of breast cancer.

  2002influential reference
• Childhood and adult milk consumption and risk of premenopausal breast cancer in a cohort of 48,844 women—the Norwegian women and cancer study

  2001cited by this paper
• Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology.

  2001cited by this paper
• Association of menstrual and reproductive factors with breast cancer risk: Results from the Shanghai breast cancer study

  2000cited by this paper
• Antimutagenic and some other effects of conjugated linoleic acid

  2000cited by this paper
• Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk.

  2000cited by this paper
• Role of the insulin-like growth factor family in cancer development and progression.

  2000cited by this paper
• Inverse Association Between Dietary and Serum Conjugated Linoleic Acid and Risk of Breast Cancer in Postmenopausal Women

  2000cited by this paper
• A case-control study of galactose consumption and metabolism in relation to ovarian cancer.

  2000cited by this paper
• Milk fat conjugated linoleic acid (CLA) inhibits growth of human mammary MCF-7 cancer cells.

  2000cited by this paper
• Vitamin D, calcium and prevention of breast cancer: a review.

  1999cited by this paper
• Family history and the risk of breast cancer: A systematic review and meta‐analysis

  1997cited by this paper
• Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale.

  1997cited by this paper
• Dairy products and breast cancer: the IGF-I, estrogen, and bGH hypothesis.

  1997cited by this paper
• Intake of selected foods and nutrients and breast cancer risk: an age- and menopause-specific analysis.

  1997cited by this paper
• Insulin-like growth factors and their binding proteins: biological actions.

  1995cited by this paper
• Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

  1993cited by this paper
• Mammary cancer prevention by conjugated dienoic derivative of linoleic acid.

  1991cited by this paper
• Food Composition Table

  1987cited by this paper

• Dairy consumption is associated with breast cancer risk: a comprehensive meta-analysis stratified by hormone receptor and menopausal status, and age.

  2025cites this paper
• Milk-derived exosomes in breast cancer therapy: Mechanisms and therapeutic potential

  2025cites this paper
• Common Misconceptions about Diet and Breast Cancer: An Unclear Issue to Dispel

  2024influential citation
• Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles.

  2024cites this paper
• Total and cause-specific mortality associated with meat intake in a large cohort study in Korea

  2023cites this paper
• The association between breast cancer and consumption of dairy products: a systematic review

  2023cites this paper
• Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies

  2023cites this paper
• Dietary patterns and breast cancer risk, prognosis, and quality of life: A systematic review

  2023cites this paper
• Dietary and other lifestyle factors and their influence on non-communicable diseases in the Western Pacific region

  2023cites this paper
• Association between dietary habits and incident thyroid cancer: A prospective cohort study

  2023cites this paper
• Association of egg intake with risks of cardiometabolic factors among adults in China

  2022cites this paper
• Association between Milk Intake and All-Cause Mortality among Chinese Adults: A Prospective Study

  2022cites this paper
• Obesity at early adulthood increases risk of gastric cancer from the Health Examinees-Gem (HEXA-G) study

  2022cites this paper
• Dietary intake of branched-chain amino acids in relation to the risk of breast cancer

  2022cites this paper
• Intake of selected food groups in relation to risk of breast cancer

  2022cites this paper
• Association of risk factors and breast cancer among women treated at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a case–control study

  2022cites this paper
• Psicología aeronáutica y perfil de personalidad de los pilotos

  2022cites this paper
• The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies

  2021cites this paper
• The prevalence and related factors of metabolic syndrome in outpatients with first-episode drug-naive major depression comorbid with anxiety

  2021cites this paper
• Intake of Various Food Groups and Risk of Breast Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies.

  2020cites this paper
• Multi-Grain Rice Diet Decreases Risk of Breast Cancer in Korean Women: Results from the Health Examinees Study

  2020cites this paper
• Association between egg consumption and elevated fasting glucose prevalence in relation to dietary patterns in selected group of Polish adults

  2019cites this paper