Leukaemia – a developmental perspective

No abstract is available for this paper.

• Publication year

  2004

• Venue

  British Journal of Haematology

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2141.2004.04986.xPMID 15198727
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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• Association of CBFA2 mutation with decreased platelet PKC-theta and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation.

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• Regulation of pTα Gene Expression by a Dosage of E2A, HEB, and SCL*

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• Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.

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• Identification of RUNX1/AML1 as a classical tumor suppressor gene

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• Identification of a TAL1 Target Gene Reveals a Positive Role for the LIM Domain-Binding Protein Ldb1 in Erythroid Gene Expression and Differentiation

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• Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

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• Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

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• Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21.

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• The Runx genes as dominant oncogenes.

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• The LMO2 T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell Development

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• Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder.

  2003influential reference
• Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1

  2003cited by this paper
• Article Title: RUNX1 and GATA -1 Coexpression and Cooperation in Megakaryocytic Differentiation

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• Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia.

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• Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis.

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• A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases

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• GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome.

  2003cited by this paper
• Transient leukaemia – a benign form of leukaemia in newborn infants with trisomy 21

  2003influential reference
• Chromosome translocations and covert leukemic clones are generated during normal fetal development

  2002cited by this paper
• GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

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• GATA1 — A Player in Normal and Leukemic Megakaryopoiesis

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• Gradient of E2A Activity in B-Cell Development

  2002cited by this paper
• Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

  2002cited by this paper
• Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

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• Core-binding factors in haematopoiesis and leukaemia

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• Down syndrome, transient myeloproliferative syndrome, and leukemia: bridging development and neoplasia.

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• IL‐7Rα and E47: independent pathways required for development of multipotent lymphoid progenitors

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• Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

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  2001cited by this paper
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  2001influential reference
• Amplification of AML1 in childhood acute lymphoblastic leukemias

  2001cited by this paper
• Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

  2001cited by this paper
• Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemia

  2001cited by this paper
• The detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukaemia.

  2001cited by this paper
• X-linked thrombocytopenia caused by a novel mutation of GATA-1.

  2001cited by this paper
• High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21.

  2000cited by this paper
• E2A proteins: essential regulators at multiple stages of B‐cell development

  2000cited by this paper
• The TEL-AML1 Fusion Accompanied by Loss of the Untranslocated TEL Allele in B-Precursor Acute Lymphoblastic Leukaemia of Childhood

  2000cited by this paper
• High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

  2000cited by this paper
• Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

  2000cited by this paper
• SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

  2000cited by this paper
• Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein.

  2000cited by this paper
• Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo.

  2000cited by this paper
• The effect of chromosomal translocations in acute leukemias: the LMO2 paradigm in transcription and development.

  1999cited by this paper
• Prenatal origin of acute lymphoblastic leukaemia in children.

  1999cited by this paper
• THE AML1‐ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE

  1999influential reference
• The role of TEL fusion genes in pediatric leukemias

  1999cited by this paper
• Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.

  1999cited by this paper
• Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice

  1999cited by this paper
• Transient myeloproliferative disorder (transient leukemia) and hematologic manifestations of Down syndrome.

  1999cited by this paper
• Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

  1999cited by this paper
• An Intricate Web: Chemokine Receptors, HIV‐1 and Hematopoiesis

  1998cited by this paper
• The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.

  1998cited by this paper
• Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.

  1998influential reference
• Transcription factor GATA‐1 in megakaryocyte development

  1998cited by this paper
• The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.

  1998cited by this paper
• Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development.

  1998cited by this paper
• Analysis of TEL proteins in human leukemias

  1998cited by this paper
• A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development

  1997cited by this paper
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  1997cited by this paper
• Expression of the SIL gene is correlated with growth induction and cellular proliferation.

  1997cited by this paper
• Leukemia and/or myeloproliferative syndrome in neonates with Down syndrome.

  1997cited by this paper
• The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins

  1997cited by this paper
• An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T‐cell malignancies in transgenic mice

  1997cited by this paper
• E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

  1997cited by this paper
• The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

  1997cited by this paper
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  1996cited by this paper
• Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

  1996cited by this paper
• The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.

  1996cited by this paper
• The CBFb subunit is essential for CBFa2 (AML1)function in vivo

  1996cited by this paper
• Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

  1996influential reference
• The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
• Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia.

  1993cited by this paper
• Leukemia in Down syndrome: a review.

  1992cited by this paper
• Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.

  1992cited by this paper
• Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.

  1990cited by this paper
• The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

  1989cited by this paper
• Speculations on the cause of childhood acute lymphoblastic leukemia.

  1988cited by this paper
• Megakaryoblastic leukemia and Down's syndrome: a review.

  1987cited by this paper

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  2019influential citation
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  2018cites this paper
• Leukemia in Down Syndrome Children Based on National Estimates.

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
• Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis

  2012cites this paper
• MiR-125 in normal and malignant hematopoiesis

  2012cites this paper
• Caudal genes in blood development and leukemia

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
• Identification of DeltaEF1 as a novel target that is negatively regulated by LMO2 in T‐cell leukemia

  2010cites this paper
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  2009cites this paper
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  2009cites this paper
• Constitutional aneuploidy and cancer predisposition.

  2009cites this paper
• Transcriptional regulation by TAL1: A link between epigenetic modifications and erythropoiesis

  2009cites this paper
• Effect of LMO2 protein expression on survival in chronic myeloid leukemia patients treated with imatinib mesylate

  2009cites this paper
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  2008cites this paper
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  2008cites this paper
• Tobacco use, body mass index, and the risk of leukemia and multiple myeloma: a nationwide cohort study in Sweden.

  2007cites this paper
• Perspective: chromosomal aneuploidy in leukemia—lessons from down syndrome

  2006cites this paper
• Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals

  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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