Neuropilin-1 identifies a subset of bone marrow Gr1- monocytes that can induce tumor vessel normalization and inhibit tumor growth.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cancer Research

• Publication date

  2012-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-12-0762PMID 23222303
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice.

  2012cited by this paper
• Toward a functional characterization of blood monocytes

  2011influential reference
• HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

  2011cited by this paper
• Targeting neuropilin-1 in human leukemia and lymphoma.

  2011cited by this paper
• Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

  2011cited by this paper
• Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models

  2011cited by this paper
• HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

  2011cited by this paper
• Targeting hypoxia in cancer therapy

  2011cited by this paper
• Development of Monocytes, Macrophages, and Dendritic Cells

  2010influential reference
• Comparison of gene expression profiles between human and mouse monocyte subsets.

  2010cited by this paper
• Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction.

  2010cited by this paper
• A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships.

  2009cited by this paper
• A new target for tumor therapy.

  2009cited by this paper
• Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models.

  2009cited by this paper
• Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.

  2009cited by this paper
• The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression.

  2009cited by this paper
• Role of Class 3 Semaphorins and Their Receptors in Tumor Growth and Angiogenesis

  2009cited by this paper
• Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

  2009cited by this paper
• Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

  2009cited by this paper
• Blood monocytes: development, heterogeneity, and relationship with dendritic cells.

  2009influential reference
• “Antimyeloangiogenic” Therapy for Cancer by Inhibiting PlGF

  2009cited by this paper
• Role of myeloid cells in tumor angiogenesis and growth.

  2008cited by this paper
• Successful Inhibition of Tumor Development by Specific Class-3 Semaphorins Is Associated with Expression of Appropriate Semaphorin Receptors by Tumor Cells

  2008cited by this paper
• The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

  2008cited by this paper
• Macrophage polarization in tumour progression.

  2008cited by this paper
• Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression.

  2008cited by this paper
• Deletion of Vascular Endothelial Growth Factor in myeloid cells accelerates tumorigenesis

  2008cited by this paper
• Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice.

  2008cited by this paper
• The role of myeloid cells in the promotion of tumour angiogenesis

  2008cited by this paper
• Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor.

  2008cited by this paper
• Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

  2007cited by this paper
• Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.

  2007cited by this paper
• VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells.

  2006cited by this paper
• Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors

  2005cited by this paper
• Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

  2005cited by this paper
• Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

  2005cited by this paper
• Angiogenesis in life, disease and medicine

  2005cited by this paper
• Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.

  2004cited by this paper
• Determination of subcutaneous tumor size in athymic (nude) mice

  2004cited by this paper
• Imaging of angiogenesis: from microscope to clinic

  2003cited by this paper
• Blood monocytes consist of two principal subsets with distinct migratory properties.

  2003influential reference
• Molecular regulation of vessel maturation

  2003cited by this paper
• Genesis: cluster analysis of microarray data

  2002cited by this paper
• Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.

  2002cited by this paper
• Angiogenesis in cancer and other diseases

  2000cited by this paper
• Hemostasis, Thrombosis, and Vascular Biology Materials and Methods Effects of Local Vegf Expression on Progenitor Cell Mobilization

  year unknowncited by this paper

• Predictive Value of Circulatory Total VEGF-A and VEGF-A Isoforms for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Patients with Non-Small-Cell Lung Cancer

  2025cites this paper
• Serum VEGF-A as a biomarker for the addition of bevacizumab to chemo-immunotherapy in metastatic NSCLC

  2025cites this paper
• The alternatively spliced diacylglycerol kinase gamma-Δ exon13 transcript generated under hypoxia promotes glioblastoma progression

  2025cites this paper
• NRP1-expressing monocyte/macrophages promote arteriogenesis in the ischemic limb

  2024influential citation
• EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening

  2024cites this paper
• Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling

  2024cites this paper
• Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

  2024cites this paper
• The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

  2023cites this paper
• Enhanced angiogenic properties of umbilical cord blood primed by OP9 stromal cells ameliorates neurological deficits in cerebral infarction mouse model

  2023cites this paper
• Semaphorin 3A in the Immune System: Twenty Years of Study

  2022influential citation
• Inflammatory cells in tumor microenvironment

  2021cites this paper
• Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation

  2021cites this paper
• Plasmacytoid dendritic cells in the eye.

  2020cites this paper
• RETRACTED: Contact co-culture of osteoblasts and sympathetic neuronal cells enhances osteoblast differentiation

  2020cites this paper
• Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells

  2020cites this paper
• Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.

  2019cites this paper
• Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis

  2019cites this paper
• Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin

  2019cites this paper
• Class-3 Semaphorins and Their Receptors: Potent Multifunctional Modulators of Tumor Progression

  2019cites this paper
• Benefits and Pitfalls of Tumor Vessel Normalization

  2019cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1512 Neuropilin-1 regulation of tumor vascularization and growth

  2018influential citation
• Exploring mechanisms regulating the heterogeneity of Tumor-Associated Macrophages

  2018cites this paper
• Downregulating Heparanase-Induced Vascular Normalization: A New Approach To Increase the Bioavailability of Chemotherapeutics in Solid Tumors.

  2018cites this paper
• Comparative Anti-Angiogenesis Study between Allicin Nanoparticle and Normal Allicin from Garlic (Allium Sativum Linn)

  2018cites this paper
• Tumor-associated macrophages and microglia : double-edged sword in tumor evolvement and invasion

  2018cites this paper
• Development and functions of patrolling monocytes and kidney resident macrophages

  2018cites this paper
• The Role of the Neuropilins in Developmental Angiogenesis

  2017cites this paper
• Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

  2017cites this paper
• The Role of Angiogenesis in Cancer Treatment

  2017cites this paper
• The Role of Semaphorin 3A in Bone Remodeling

  2017cites this paper
• Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity

  2017cites this paper
• Neuropilin-1-Expressing Monocytes: Implications for Therapeutic Angiogenesis and Cancer Therapy

  2017cites this paper
• Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization

  2016cites this paper
• Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

  2016cites this paper
• The semaphorins and their receptors as modulators of tumor progression.

  2016cites this paper
• VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans

  2016cites this paper
• Dynamics of VEGF-A and its Receptors in Cancer Vascularization – an Overview

  2016cites this paper
• The role of the semaphorins in cancer

  2016cites this paper
• Regulation of VEGFR2 signaling in angiogenesis and vascular permeability

  2016cites this paper
• VEGF blockade enhances the antitumor effect of BRAFV 600E inhibition

  2016cites this paper
• Effects of Pleiotrophin on endothelial and inflammatory cells: Pro-angiogenic and anti-inflammatory properties and potential role for vascular bio-prosthesis endothelialization.

  2015cites this paper
• Depletion of CD11c+ cells in the CD11c.DTR model drives expansion of unique CD64+ Ly6C+ monocytes that are poised to release TNF-α

  2015cites this paper
• The potential of class 3 semaphorins as both targets and therapeutics in cancer

  2015cites this paper
• Regulation of Angiogenesis and Tumor Progression by Semaphorins

  2015cites this paper
• VEGF dose regulates vascular stabilization through Semaphorin3A and the Neuropilin-1+ monocyte/TGF-β1 paracrine axis

  2015cites this paper
• Semaphorins

  2015cites this paper
• Trends in Malignant Glioma Monoclonal Antibody Therapy

  2015cites this paper
• Tumor angiogenesis: methods to analyze tumor vasculature and vessel normalization in mouse models of cancer.

  2015cites this paper
• Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity

  2015cites this paper
• Semaphorins in cardiovascular medicine.

  2014cites this paper
• Tumor dormancy and the angiogenic switch: possible implications of bone marrow- derived cells.

  2014cites this paper
• Neuropilin-1 Expression Is Induced on Tolerant Self-Reactive CD8+ T Cells but Is Dispensable for the Tolerant Phenotype

  2014cites this paper
• Vascular endothelial growth factor-B in physiology and disease.

  2014cites this paper
• Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk.

  2014cites this paper
• Neuropilin regulation of angiogenesis.

  2014cites this paper
• Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability

  2014cites this paper
• Adeno-Associated Virus Vectors as Therapeutic and Investigational Tools in the Cardiovascular System

  2014cites this paper
• Class 3 semaphorin in angiogenesis and lymphangiogenesis.

  2014cites this paper
• The role of semaphorins and their receptors in vascular development and cancer.

  2013cites this paper
• The role of immune semaphorins in cancer progression.

  2013cites this paper
• Distinct roles of DKK1 and DKK2 in tumor angiogenesis

  2013cites this paper
• Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk

  year unknowncites this paper