Characterisation of pentamidine-resistant Trypanosoma brucei brucei.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Molecular and biochemical parasitology (Print)

• Publication date

  1995-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0166-6851(94)00215-9PMID 7770092
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenil) and in vitro simulation of drug-concentration-time profiles in cattle plasma.

  1993cited by this paper
• Inhibition of topoisomerases in African trypanosomes.

  1993cited by this paper
• Arsenical-resistant trypanosomes lack an unusual adenosine transporter

  1993cited by this paper
• Polyamine and pentamidine metabolism in African trypanosomes.

  1993cited by this paper
• A calmodulin-stimulated Ca2+ pump in plasma-membrane vesicles from Trypanosoma brucei; selective inhibition by pentamidine.

  1993cited by this paper
• Ca2+ transport by digitonin-permeabilized Leishmania donovani. Effects of Ca2+, pentamidine and WR-6026 on mitochondrial membrane potential in situ.

  1992cited by this paper
• Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism.

  1992cited by this paper
• Problems and Pitfalls in the Assay of Pentamidine

  1992cited by this paper
• High-efficiency clonal growth of bloodstream- and insect-form Trypanosoma brucei on agarose plates.

  1992cited by this paper
• Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

  1990cited by this paper
• Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs.

  1990cited by this paper
• Hydroxylation of pentamidine by rat liver microsomes.

  1990cited by this paper
• Distribution of pentamidine in patients with AIDS.

  1988cited by this paper
• Flow cytofluorimetric analysis of drug accumulation by multidrug-resistant Trypanosoma brucei brucei and T. b. rhodesiense.

  1987cited by this paper
• Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).

  1986cited by this paper
• Use of a specific and sensitive assay to determine pentamidine pharmacokinetics in patients with AIDS.

  1986cited by this paper
• Use of a new bioassay to study pentamidine pharmacokinetics.

  1985cited by this paper
• Pentamidine: a review.

  1985cited by this paper
• High-performance liquid chromatographic method for quantitation of pentamidine in blood serum.

  1985cited by this paper
• Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei

  1984cited by this paper
• Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei.

  1984cited by this paper
• Effect of pentamidine isethionate on the ultrastructure and morphology of Leishmania mexicana amazonensis in vitro.

  1982cited by this paper
• The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei.

  1980cited by this paper
• Complex inhibition of thymidylate synthetase by aromatic diamidines: evidence for both rapid, freely reversible and slowly progressive, nonequilibrium inhibition.

  1977cited by this paper
• Pentamidine transport in Trypanosoma brucei-kinetics and specificity.

  1976cited by this paper
• Pentamidine transport and sensitivity in brucei-group trypanosomes.

  1976cited by this paper
• Observations sur la sensibilité aux diamidines de souches de Trypanosoma gambiense récement isolées en republique du Zaire.

  1972cited by this paper
• The African trypanosomiases

  1970cited by this paper
• Some effects of pentamidine di-isethionate on Crithidia fasciculata.

  1969cited by this paper
• Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangers

  1968cited by this paper
• Drug resistance in trapanososmes: cross-resitance analyses.

  1959cited by this paper
• DRUG RESISTANCE IN TRYPANOSOMES; CROSS-RESISTANCE ANALYSES

  1959cited by this paper
• The preparation of a strain of Trypanosoma rhodesiense resistant to stilbamidine and some observations on its nature.

  1955cited by this paper
• 20. A chemotherapeutic comparison of the trypanocidal action of some aromatic diamidines

  1942cited by this paper

• Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

  2024cites this paper
• Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs

  2023cites this paper
• Evolution of protein trafficking in kinetoplastid parasites: Complexity and pathogenesis

  2018cites this paper
• New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites

  2016cites this paper
• THESE pour le DIPLOME D'ETAT DE DOCTEUR EN PHARMACIE

  2015cites this paper
• Sickness of Second-Stage African Sleeping Treatment 28DAP010, a Novel Diamidine for Evaluation of In Vivo and In Vitro

  2014cites this paper
• In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness

  2014cites this paper
• analogs as trypanocides. In vivo efficacies of 5'-methylthioadenosine

  2013cites this paper
• Novel Treatment of African Trypanosomiasis

  2013cites this paper
• Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

  2012cites this paper
• Mitochondria and Trypanosomatids: Targets and Drugs

  2011cites this paper
• Diamidine transporters of Trypanosoma brucei

  2011cites this paper
• Linkage mapping and genetic analysis of Trypanosoma brucei

  2010influential citation
• Antiprotozoal/Antiparasitic Agents

  2010cites this paper
• Diagnosis and Inhibition Tools in Medicinal Chemistry

  2009cites this paper
• Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

  2009cites this paper
• Biochemical and Functional Characterization of Serine Proteases in Leishmania

  2009cites this paper
• Drug Resistance in African Trypanosomiasis

  2009cites this paper
• Trypanocidal drugs: mechanisms, resistance and new targets

  2009cites this paper
• Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis

  2008cites this paper
• Detection of mutant P2 adenosine transporter (TbAT1) gene in Trypanosoma brucei gambiense isolates from northwest Uganda using allele‐specific polymerase chain reaction

  2007cites this paper
• Drugs and drug resistance in African trypanosomiasis.

  2007cites this paper
• Die post-SELEX Optimierung des Trypanosomen-spezifischen RNA-Aptamers 2-16

  2007cites this paper
• Accumulation and Intracellular Distribution of Aromatic Diamidines in African Trypanosomes

  2007cites this paper
• Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease

  2007cites this paper
• Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes

  2007cites this paper
• Amino acid transporters & amino acid metabolism in Trypanosoma brucei brucei.

  2007cites this paper
• Antiprotozoal Agents (African Trypanosomiasis, Chagas Disease, and Leishmaniasis)

  2007cites this paper
• Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

  2006cites this paper
• Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols.

  2006cites this paper
• Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.

  2006cites this paper
• Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes

  2006cites this paper
• Targeting of toxic compounds to the trypanosome's interior.

  2006cites this paper
• Aromatic diamidines as antiparasitic agents

  2005cites this paper
• Synthesis of 2-azabicyclo[3.2.2]nonanes from bicyclo[2.2.2]octan-2-ones and their activities against Trypanosoma brucei rhodesiense and Plasmodium falciparum K1.

  2005cites this paper
• Antiprotozoal activities of new bicyclo[2.2.2]octan-2-imines and esters of bicyclo[2.2.2]octan-2-ols.

  2005cites this paper
• A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats

  2005influential citation
• Biochemical and molecular characterisation of purine transporters of Trypanosoma brucei brucei

  2004cites this paper
• 6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.

  2004cites this paper
• Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis

  2003cites this paper
• Drug transport and drug resistance in African trypanosomes.

  2003cites this paper
• Chemotherapy of human African trypanosomiasis: current and future prospects.

  2003cites this paper
• Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.

  2003cites this paper
• Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion

  2002cites this paper
• Transporters in African trypanosomes: role in drug action and resistance.

  2001cites this paper
• Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy.

  2001cites this paper
• Transporters in African trypanosomes: role in drug action and resistance.

  2001cites this paper
• Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.

  2001cites this paper
• Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle.

  2001cites this paper
• Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.

  2000cites this paper
• The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.

  1999cites this paper
• Surface receptors and transporters of Trypanosoma brucei.

  1998cites this paper
• An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

  1998cites this paper
• Investigations on mechanisms of acquisition of drug resistance in trypanosomes

  1998cites this paper
• A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin

  1998cites this paper
• Drug resistance in Leishmania: similarities and differences to other organisms.

  1998cites this paper
• Characterization of a Nucleoside/Proton Symporter in ProcyclicTrypanosoma brucei brucei *

  1998cites this paper
• Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.

  1997cites this paper
• Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes

  1997influential citation
• In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides

  1997cites this paper
• Modulation of mitochondrial electrical potential: a candidate mechanism for drug resistance in African trypanosomes.

  1997cites this paper
• Identification of three ABC transporter genes in Trypanosomabrucei spp.

  1997cites this paper
• Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives

  1996cites this paper
• Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria.

  1996cites this paper
• Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes.

  1996cites this paper
• A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.

  1995cites this paper
• Uptake of Diamidine Drugs by the P2 Nucleoside Transporter in Melarsen-sensitive and -resistant Trypanosoma brucei brucei(*)

  1995cites this paper