Multiple Functions of D-Type Cyclins Can Antagonize pRb-Mediated Suppression of Proliferation

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell Cycle

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.4.2.1485PMID 15684604
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Retinoblastoma Protein and Cell Cycle Control Review

  2004cited by this paper
• Cellular Senescence Requires CDK5 Repression of Rac1 Activity

  2004cited by this paper
• The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression.

  2004cited by this paper
• Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

  2003cited by this paper
• ERM Proteins and Cdk5 in Cellular Senescence

  2003cited by this paper
• Role of the Retinoblastoma Protein in Differentiation and Senescence

  2003cited by this paper
• Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

  2003cited by this paper
• A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.

  2003cited by this paper
• CtBP, an unconventional transcriptional corepressor in development and oncogenesis.

  2002cited by this paper
• Distinct Phosphorylation Events Regulate p130- and p107-mediated Repression of E2F-4*

  2002cited by this paper
• Cyclin D1 Represses the Basic Helix-Loop-Helix Transcription Factor, BETA2/NeuroD*

  2002cited by this paper
• The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.

  2001cited by this paper
• The Rb/E2F pathway and cancer.

  2001cited by this paper
• Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner.

  2001cited by this paper
• Cyclin D1 Represses STAT3 Activation through a Cdk4-independent Mechanism*

  2001cited by this paper
• Requirement for p27KIP1 in Retinoblastoma Protein-Mediated Senescence

  2001cited by this paper
• D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability.

  1999cited by this paper
• Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth.

  1998cited by this paper
• Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature‐sensitive retinoblastoma protein

  1998cited by this paper
• Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

  1998cited by this paper
• Retinoblastoma protein represses transcription by recruiting a histone deacetylase

  1998cited by this paper
• Retinoblastoma protein recruits histone deacetylase to repress transcription

  1998cited by this paper
• Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

  1998cited by this paper
• Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.

  1998cited by this paper
• Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).

  1998cited by this paper
• Rb interacts with histone deacetylase to repress transcription.

  1998cited by this paper
• Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence.

  1998cited by this paper
• Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism

  1998cited by this paper
• The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis.

  1997cited by this paper
• Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4

  1997cited by this paper
• CDK-independent activation of estrogen receptor by cyclin D1.

  1997cited by this paper
• Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

  1997cited by this paper
• Molecular characterization of 12p abnormalities in hematologic malignancies: deletion of KIP1, rearrangement of TEL, and amplification of CCND2.

  1996cited by this paper
• The consensus motif for phosphorylation by cyclin D1‐Cdk4 is different from that for phosphorylation by cyclin A/E‐Cdk2.

  1996cited by this paper
• Cancer Cell Cycles

  1996cited by this paper
• Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1

  1996cited by this paper
• The retinoblastoma protein pathway and the restriction point.

  1996cited by this paper
• Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

  1996cited by this paper
• Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

  1996cited by this paper
• The retinoblastoma protein and cell cycle control.

  1995cited by this paper
• Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

  1995cited by this paper
• Overexpression of cyclin D2 in chronic B-cell malignancies.

  1995cited by this paper
• Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

  1995cited by this paper
• D-type cyclins.

  1995cited by this paper
• p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

  1994cited by this paper
• Function of a human cyclin gene as an oncogene.

  1994cited by this paper
• Distinct roles for cyclin-dependent kinases in cell cycle control.

  1993cited by this paper
• Physical interaction of the retinoblastoma protein with human D cyclins.

  1993cited by this paper
• Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

  1993cited by this paper
• Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

  1993cited by this paper
• Amplification of cyclin genes in colorectal carcinomas.

  1993cited by this paper
• Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

  1993cited by this paper
• Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

  1993cited by this paper
• The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2.

  1993influential reference
• Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.

  1992cited by this paper
• Modulation of retinoblastoma protein activity during the cell cycle.

  1991cited by this paper
• Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.

  1991cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
• C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

  1990cited by this paper
• The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.

  1989cited by this paper
• Cellular targets for transformation by the adenovirus E1A proteins.

  1989cited by this paper
• SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.

  1988cited by this paper
• Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.

  1988cited by this paper
• Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation

  1988cited by this paper
• The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells

  1988cited by this paper
• A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

  1988cited by this paper
• Functional domains of adenovirus type 5 E1a proteins.

  1987cited by this paper
• Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes

  1986cited by this paper

• A Necessary Role for Cyclin D2 Induction During Colon Cancer Progression Mediated by L1

  2024cites this paper
• Hepatocellular carcinoma evades RB1-induced senescence by activating the FOXM1–FOXO1 axis

  2022cites this paper
• The cell cycle regulator cyclin D1 modulates the activity of α4-containing GABA A receptors

  2022cites this paper
• Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors

  2022cites this paper
• Predicted landscape of RETINOBLASTOMA-RELATED LxCxE-mediated interactions across the Chloroplastida.

  2022cites this paper
• Cyclin D3 restricts SARS‐CoV‐2 envelope incorporation into virions and interferes with viral spread

  2022cites this paper
• At least two high-risk cytogenetic abnormalities indicate the inferior outcomes for newly diagnosed multiple myeloma patients: a real-world study in China

  2021cites this paper
• Methods to Study Posttranslational Modification Patterns in Cytotoxic T-Cells and Cancer.

  2021cites this paper
• Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human Papillomavirus

  2021cites this paper
• The central role of the transcriptional regulator IκBζ in psoriasis

  2020cites this paper
• Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

  2020cites this paper
• The membrane-associated form of cyclin D1 enhances cellular invasion

  2020cites this paper
• Correction of RNA-Binding Protein CUGBP1 and GSK3β Signaling as Therapeutic Approach for Congenital and Adult Myotonic Dystrophy Type 1

  2019cites this paper
• Mammalian Development and Cancer: A Brief History of Mice Lacking D-Type Cyclins or CDK4/CDK6

  2018cites this paper
• Cyclin D1, Metabolism, and the Autophagy-Senescence Balance

  2018cites this paper
• Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2

  2018cites this paper
• Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.

  2018cites this paper
• CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells

  2017cites this paper
• Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins

  2017cites this paper
• Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus.

  2017cites this paper
• Chemotherapeutic effect of Ellagic acid encapsulated chitosan nanoparticles on DMBA induced hamster buccal pouch carcinogenesis

  2017cites this paper
• Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation.

  2017influential citation
• Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients

  2017cites this paper
• The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

  2016cites this paper
• Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D

  2016cites this paper
• HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block

  2016cites this paper
• CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

  2016cites this paper
• APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway

  2016cites this paper
• Regulation of Ciz1 by Cyclin A-Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation

  2016cites this paper
• Potential gene regulatory role for cyclin D3 in muscle cells

  2015cites this paper
• Potential gene regulatory role for cyclin D3 in muscle cells

  2015cites this paper
• Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis

  2015cites this paper
• Overexpression of microRNA-95-3p suppresses brain metastasis of lung adenocarcinoma through downregulation of cyclin D1

  2015cites this paper
• Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97*

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection

  2014cites this paper
• Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present

  2014cites this paper
• Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1

  2014cites this paper
• Cyclin D 1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC 1

  2014cites this paper
• Iso-suillin isolated from Suillus luteus, induces G1 phase arrest and apoptosis in human hepatoma SMMC-7721 cells.

  2014cites this paper
• Cyclin D1 Represses Gluconeogenesis via Inhibition of the Transcriptional Coactivator PGC1α

  2014cites this paper
• A New Perspective on Cyclin D1: Beyond Cell Cycle Regulation

  2013cites this paper
• Multinucleated cells are involved in normal development and apoptosis in mouse testes.

  2013cites this paper
• Cell cycle arrest, extracellular matrix changes and intrinsic apoptosis in human melanoma cells are induced by Boron Neutron Capture Therapy.

  2013cites this paper
• Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration

  2012cites this paper
• Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

  2012cites this paper
• Common genetic variants in cell cycle pathway are associated with survival in stage III-IV non-small-cell lung cancer.

  2011cites this paper
• Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway

  2011cites this paper
• Cyclin D as a therapeutic target in cancer

  2011cites this paper
• Cell cycle regulation and interneuron production

  2011cites this paper
• Specific Overexpression of Cyclin E·CDK2 in Early Preinvasive and Primary Breast Tumors in Female ACI Rats Induced by Estrogen

  2010cites this paper
• Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.

  2010cites this paper
• Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance

  2010cites this paper
• Somatic alterations in the melanoma genome: A high‐resolution array‐based comparative genomic hybridization study

  2010cites this paper
• Cationic nanoparticles for cancer therapy

  2010cites this paper
• Mieloma Múltiple: Alteraciones génicas y cromosómicas no translocacionales y sus implicaciones pronósticas

  2010cites this paper
• Biomarkers in Osteosarcoma.

  2009cites this paper
• Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells

  2009influential citation
• Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells.

  2009cites this paper
• Cell cycle arrest induced by engagement of B7‐H4 on Epstein–Barr virus‐positive B‐cell lymphoma cell lines

  2009cites this paper
• Cyclin D1 overexpression increases susceptibility to 4‐nitroquinoline‐1‐oxide‐induced dysplasia and neoplasia in murine squamous oral epithelium

  2009cites this paper
• The Phylogenetic Analysis of Animal and Plant D-Type Cyclins

  2008cites this paper
• Casein Kinase II Motif-Dependent Phosphorylation of Human Papillomavirus E7 Protein Promotes p130 Degradation and S-Phase Induction in Differentiated Human Keratinocytes

  2008cites this paper
• Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons.

  2008cites this paper
• Do Different Disorders in Cell Cycle Regulation Account for Different Biological Behavior of Urothelial and Sinonasal Inverted Papillomas?

  2008cites this paper
• Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment.

  2008cites this paper
• Apigenin-induced Cell Cycle Arrest is Mediated by Modulation of MAPK, PI3K-Akt, and Loss of Cyclin D1 Associated Retinoblastoma Dephosphorylation in Human Prostate Cancer Cells

  2007cites this paper
• Genetic events in the pathogenesis of multiple myeloma.

  2007cites this paper
• Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition

  2007cites this paper
• Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells

  2007cites this paper
• CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16INK4a-Independent Mechanisms

  2007cites this paper
• Non-genomic effects of 17β-estradiol in activation of the ERK1/ERK2 pathway induces cell proliferation through upregulation of cyclin D1 expression in bovine artery endothelial cells

  2007cites this paper
• Perspectives on c-Myc, Cyclin D1, and their interaction in cancer formation, progression, and response to chemotherapy.

  2007cites this paper
• Interweaving the Cell Cycle Machinery with Cell Differentiation

  2007cites this paper
• The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.

  2007cites this paper
• CURRENT IMPLICATIONS FOR CANCER DETECTION, PREVENTION, AND THERAPEUTICS*

  2006cites this paper
• Posttranslational Protein Modifications

  2006cites this paper
• Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.

  2006influential citation
• p75NTR enhances PC12 cell tumor growth by a non-receptor mechanism involving downregulation of cyclin D2.

  2006cites this paper
• Induction of Transcriptionally Active Jun Proteins Regulates Drug-induced Senescence*

  2006cites this paper
• From Cell Cycle to Differentiation: An Expanding Role for Cdk6

  2006cites this paper
• TFII-I: Connecting Mitogenic Signals to Cell Cycle Regulation

  2006cites this paper
• Targeting Cyclins and Cyclin-Dependent Kinases in Cancer: Lessons from Mice, Hopes for Therapeutic Applications in Humans

  2006cites this paper
• Distinct Specificities of pRb Phosphorylation by CDK4 Activated by Cyclin D1 or Cyclin D3: Differential Involvement in the Distinct Mitogenic Modes of Thyroid Epithelial Cells

  2006cites this paper
• Structural Basis for the Modulation of CDK-Dependent/Independent Activity of Cyclin D1

  2006cites this paper
• The Cell Cycle Regulators P16INK4a, P15INK4b and Cyclin D1: Relationship to Clinicopathological Parameters and Disease-free Survival in Laryngeal Carcinoma Patients.

  2005cites this paper
• Cyclins and cdks in development and cancer: a perspective

  2005cites this paper
• Meeting report: The international conference on tumor progression and therapeutic resistance.

  2005cites this paper