Human FSH isoforms: carbohydrate complexity as determinant of in-vitro bioactivity.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2001-03-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0303-7207(00)00453-6PMID 11306170
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential effects of the charge variants of human follicle-stimulating hormone.

  2000cited by this paper
• Oestrogens regulate pituitary Æ 2,3-sialyltransferase messenger ribonucleic acid levels in the female rat

  1999cited by this paper
• Androgen Regulation of Immunological and Biological Activities of Pituitary Follicle-Stimulating Hormone Isoforms inMale Rats

  1999cited by this paper
• Receptor binding activity and in vitro biological activity of the human FSH charge isoforms as disclosed by heterologous and homologous assay systems

  1999cited by this paper
• Oestrogens regulate pituitary alpha2,3-sialyltransferase messenger ribonucleic acid levels in the female rat.

  1999cited by this paper
• Role of glycosylation in function of follicle-stimulating hormone

  1999cited by this paper
• Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states.

  1998cited by this paper
• A less acidic human follicle-stimulating hormone preparation induces tissue-type plasminogen activator enzyme activity earlier than a predominantly acidic analogue in phenobarbital-blocked pro-oestrous rats.

  1998cited by this paper
• Glycosylation variants of human TSH selectively activate signal transduction pathways.

  1997cited by this paper
• Structure-function relationship of recombinant follicle stimulating hormone (Puregon).

  1996cited by this paper
• FSH isoforms: bio and immuno‐activities in post‐menopausal and normal menstruating women

  1996cited by this paper
• Internal carbohydrate complexity of the oligosaccharide chains of recombinant human follicle stimulating hormone (Puregon, Org 32489): a comparison with Metrodin and Metrodin-HP.

  1996cited by this paper
• Immunological and biological activities of pituitary FSH isoforms in prepubertal male rats: effect of antiandrogens.

  1996cited by this paper
• Recombinant hormones: In-vitro biopotency and glycoform distribution of recombinant human follicle stimulating hormone (Org 32489), Metrodin and Metrodin—HP

  1995cited by this paper
• In-vitro biopotency and glycoform distribution of recombinant human follicle stimulating hormone (Org 32489), Metrodin and Metrodin-HP.

  1995cited by this paper
• Follicle-stimulating isohormones: characterization and physiological relevance.

  1995cited by this paper
• Polymorphism of human pituitary FSH: analysis of immunoreactivity and in vitro bioactivity of different molecular species.

  1994cited by this paper
• Immunological activities of highly purified isoforms of human FSH correlate with in vitro bioactivities.

  1993cited by this paper
• FSH isoforms, radioimmunoassays, bioassays, and their significance.

  1992cited by this paper
• Biological characterization of the naturally occurring analogues of intrapituitary human follicle-stimulating hormone.

  1992cited by this paper
• Effects of neonatal androgenization on the chromatofocusing pattern of anterior pituitary FSH in the female rat.

  1990cited by this paper
• Follicle-stimulating hormones in anterior pituitary glands from children and adults differ in relation to sex and age.

  1989cited by this paper
• Modulation of serum follicle-stimulating hormone bioactivity and isoform distribution by estrogenic steroids in normal women and in gonadal dysgenesis.

  1988cited by this paper
• An improved in vitro bioassay for follicle-stimulating hormone (FSH): suitable for measurement of FSH in unextracted human serum.

  1987cited by this paper
• Influence of the assay method used on the selection of the most active forms of FSH from the human pituitary.

  1986cited by this paper
• Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides.

  1986cited by this paper
• Similar isoelectric profiles of FSH from gonadotroph cell adenomas and non-adenomatous pituitaries.

  1986cited by this paper
• The regulation of metabolic clearance rate of human FSH in mice by variation of the molecular structure of the hormone.

  1986cited by this paper
• Assembly of asparagine-linked oligosaccharides.

  1985cited by this paper
• Heterogeneity of rat FSH by chromatofocusing: studies on in-vitro bioactivity of pituitary FSH forms and effect of neuraminidase treatment.

  1985cited by this paper
• Existence of multiple forms of follicle-stimulating hormone within the anterior pituitaries of cynomolgus monkeys.

  1984cited by this paper
• Coordination between enzyme specificity and intracellular compartmentation in the control of protein‐bound oligosaccharide biosynthesis

  1984cited by this paper
• Human testicular androgen-binding protein shares immunodeterminants with serum testosterone-estradiol-binding globulin.

  1984cited by this paper
• Higher plasma disappearance rate in the mouse for pituitary follicle-stimulating hormone of young women compared to that of men and elderly women.

  1984cited by this paper
• Sexual maturation in female rats: time-related changes in the isoelectric focusing pattern of anterior pituitary follicle-stimulating hormone.

  1983cited by this paper
• Studies on pituitary follitropin. X. Biochemical, receptor binding and immunological properties of deglycosylated ovine hormone.

  1982cited by this paper
• Multiple species of follicle-stimulating hormone exist within the anterior pituitary gland of male golden hamsters.

  1982cited by this paper
• Fractionation of asparagine-linked oligosaccharides by serial lectin-Agarose affinity chromatography. A rapid, sensitive, and specific technique.

  1982cited by this paper
• Studies on pituitary follitropin. XI. Induction of hormonal antagonistic activity by chemical deglycosylation.

  1982cited by this paper
• Structural requirements for the binding of oligosaccharides and glycopeptides to immobilized wheat germ agglutinin.

  1981cited by this paper
• The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant.

  1981cited by this paper
• Large-scale preparation of highly purified pyrogen-free human growth hormone for clinical use.

  1979cited by this paper
• A structural basis for four distinct elution profiles on concanavalin A--Sepharose affinity chromatography of glycopeptides.

  1979cited by this paper
• Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

  1978cited by this paper
• Plasma concentration of oestradiol-17beta in premature thelarche and in different types of sexual precocity.

  1976cited by this paper
• The role of sialic acid in determining the survival of glycoproteins in the circulation.

  1971cited by this paper
• THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

  1963cited by this paper

• Hypo-glycosylated FSH enhances the ovarian microenvironment for follicular development compared to fully glycosylated FSH

  2025cites this paper
• Biased signaling by human follicle-stimulating hormone variants: Secrets behind carbohydrates.

  2025cites this paper
• Low-scale production and purification of a biologically active optimized form of the antitumor protein growth arrest specific 1 (GAS1) in a mammalian system for post-translational analysis

  2023cites this paper
• In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity

  2020cites this paper
• FSH for the Treatment of Male Infertility

  2020cites this paper
• The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

  2020cites this paper
• Neuroendocrine, Autocrine, and Paracrine control of follicle-stimulating hormone secretion.

  2020cites this paper
• Gonadotropin Glycoforms Circulating in Women Using Progestins of the Levonorgestrel Family for Contraception

  2020cites this paper
• Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications

  2020cites this paper
• Role of Glycosylation in Modulating Therapeutic Efficiency of Protein Pharmaceuticals

  2019cites this paper
• Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males

  2019cites this paper
• Electrophysiological Responses to Different Follicle-Stimulating Hormone Isoforms on Human Cumulus Oophorus Cells: Preliminary Results

  2018cites this paper
• Comparative pharmacology of a new recombinant FSH expressed by a human cell line

  2017cites this paper
• Role of FSH glycan structure in the regulation of Sertoli cell inhibin production.

  2017cites this paper
• Follicle-Stimulating Hormone

  2016cites this paper
• — A LATIN AMERICAN PERSPECTIVE ON G PROTEIN-COUPLED RECEPTORS The Follitropin Receptor : Matching Structure and Function

  2016influential citation
• A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7Δ) Asn(24Δ)) FSHβ subunit fails to rescue Fshb null mice.

  2016cites this paper
• The Follitropin Receptor: Matching Structure and Function

  2016influential citation
• Identification, caractérisation et validation de biomarqueurs liés à l’immunothérapie allergénique

  2015cites this paper
• Changes in Glycosylation of Pituitary Gonadotropins in Polycystic Ovary Syndrome

  2014cites this paper
• Glycotherapy: new advances inspire a reemergence of glycans in medicine.

  2014cites this paper
• Concanavalin-A induces granulosa cell death and inhibits FSH-mediated follicular growth and ovarian maturation in female rats.

  2013cites this paper
• Development and analysis of alpha 1-antitrypsin neoglycoproteins: the impact of additional N-glycosylation sites on serum half-life.

  2013cites this paper
• Effect of sialylation and complexity of FSH oligosaccharides on inhibin production by granulosa cells.

  2013cites this paper
• The glycan structure in recombinant human FSH affects endocrine activity and global gene expression in human granulosa cells.

  2013influential citation
• 1.32 – Glycomics

  2011cites this paper
• Pharmacologic profiling of corifollitropin alfa, the first developed sustained follicle stimulant.

  2011cites this paper
• The role of corifollitropin alfa in controlled ovarian stimulation for IVF in combination with GnRH antagonist

  2011cites this paper
• Novel pathways in gonadotropin receptor signaling and biased agonism

  2011cites this paper
• Absorption, Distribution, Metabolism and Excretion of Corifollitropin Alfa, a Recombinant Hormone with a Sustained Follicle-Stimulating Activity

  2010cites this paper
• Corifollitropin Alfa: A Novel Long-Acting Recombinant Follicle-Stimulating Hormone Agonist for Controlled Ovarian Stimulation

  2010cites this paper
• Glycosylation of Therapeutic Proteins

  2010cites this paper
• Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency.

  2009cites this paper
• Gonadotropins and the importance of glycosylation

  2009cites this paper
• FSH: One Hormone with Multiple Forms, or a Family of Multiple Hormones

  2009cites this paper
• Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility.

  2009cites this paper
• Chromatofocusing fails to separate hFSH isoforms on the basis of glycan structure.

  2008cites this paper
• Separation of protein charge variants with induced pH gradients using anion exchange chromatographic columns

  2008cites this paper
• Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-A in plasma from neonates with intrauterine growth restriction: proteomics screening and potential clinical implications.

  2008cites this paper
• FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity.

  2008cites this paper
• Progesterone and the distribution of pituitary gonadotropin isoforms in cattle.

  2008cites this paper
• 13C-sialic acid labeling of glycans on glycoproteins using ST6Gal-I.

  2008cites this paper
• Marked Defects in the Expression and Glycosylation of α2-HS Glycoprotein/Fetuin-A in Plasma from Neonates with Intrauterine Growth Restriction

  2008cites this paper
• Instituto de Pesquisas Energéticas e Nucleares

  2008cites this paper
• Caprine luteinizing hormone isoforms during the follicular phase and anestrus.

  2007cites this paper
• Glycosylation of therapeutic proteins in different production systems

  2007cites this paper
• Luteinizing hormone (LH) isoforms in ruminants: characterization and physiological relevance.

  2007cites this paper
• Validating a custom multiplex ELISA against individual commercial immunoassays using clinical samples.

  2007cites this paper
• Carbohydrate complexity and proportions of serum FSH isoforms in the male: lectin-based studies.

  2007cites this paper
• Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles.

  2006cites this paper
• Conjugated Estrogens and Tibolone Modify the Gonadotrophin Glycosylation Pattern in Postmenopausal Women

  2006cites this paper
• Caracterização físico-química da foliculotrofina humana (hFSH) recombinante e de suas subunidades, por cromatografia líquida de alta eficiência (HPLC) em fase reversa: comparação com a preparação de referência de hFSH de origem hipofisária do "National Hormone and Pituitary Program" dos EUA.

  2006cites this paper
• Ovine serum and pituitary isoforms of luteinising hormone during the luteal phase.

  2006cites this paper
• Effects of human pituitary FSH isoforms on mouse follicles in vitro.

  2006cites this paper
• Analysis of intact human follicle-stimulating hormone preparations by reversed-phase high-performance liquid chromatography.

  2006cites this paper
• Urofollitropin and Ovulation Induction

  2005cites this paper
• Effects of long-acting recombinant human follicle-stimulating hormone analogs containing N-linked glycosylation on murine folliculogenesis.

  2005cites this paper
• Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins.

  2005cites this paper
• Pattern of circulating luteinizing hormone isoforms during the estrous and luteal phases in Holstein heifers.

  2005cites this paper
• Basal and gonadotropin-releasing hormone-releasable serum follicle-stimulating hormone charge isoform distribution and in vitro biological-to-immunological ratio in male puberty

  2004cites this paper
• Purifi cación de cinco isoformas de la hormona luteinizante bovina (bLH). Caracterización fi sicoquímica, biológica e inmunológica Purifi cation of fibovine luteinizing hormone (bLH) isoforms. Chemical, physical, biological and immunological characterization

  2004cites this paper
• FSH isoform composition of commercial gonadotrophin preparations: a neglected aspect?

  2004cites this paper
• Chemical, physical, biological and immunological characterization

  2004cites this paper
• Long-acting follicle-stimulating hormone analogs containing N-linked glycosylation exhibited increased bioactivity compared with o-linked analogs in female rats.

  2004cites this paper
• Pregnancy and Delivery After Stimulation with rFSH of a Galatosemia Patient Suffering Hypergonadotropic Hypogonadism: Case Report

  2004cites this paper
• Effect of Dihydrotestosterone on Pituitary Follicle-Stimulating Hormone Isoforms in Adult Male Rats Treated with a Gonadotropin-Releasing Hormone Antagonist

  2003cites this paper
• Impact of Carbohydrate Heterogeneity in Function of Follicle-Stimulating Hormone: Studies Derived from in Vitro and in Vivo Models1

  2003cites this paper
• Glycosylation of an N-terminal extension prolongs the half-life and increases the in vivo activity of follicle stimulating hormone.

  2003cites this paper
• Improvement in consistency of response to ovarian stimulation with recombinant human follicle stimulating hormone resulting from a new method for calibrating the therapeutic preparation.

  2003cites this paper
• Effect of FSH and its different isoforms on maturation of oocytes from pre-ovulatory follicles.

  2002cites this paper
• Expression and characterization of functional recombinant bovine follicle‐stimulating hormone (boFSHα/β) produced in the milk of transgenic rabbits

  2002influential citation
• Effect of FSH and its different isoforms on maturation of oocytes from pre-ovulatory follicles.

  2002cites this paper
• Membrane-Assisted Isoform ImmunoAssay : Separation and determination of protein isoforms

  2002cites this paper
• Differences in Sialic Acid Residues Among Bone Alkaline Phosphatase Isoforms: A Physical, Biochemical, and Immunological Characterization

  2002cites this paper
• Intact follicle culture: what it can tell us about the roles of FSH glycoforms during follicle development.

  2002cites this paper
• Changes in the biological:immunological ratio of basal and GnRH-releasable FSH during the follicular, pre-ovulatory and luteal phases of the human menstrual cycle.

  2001cites this paper
• International Journal of Women's Health Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Review of the Safety, Efficacy, Costs and Patient Acceptability of Recombinant Follicle-stimulating Hormone for Injection in Assisting Ovulation Induction in Infer

  year unknowncites this paper