The challenge of the microenvironment in B‐cell lymphomas

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Histopathology

• Publication date

  2011-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2559.2010.03706.xPMID 21261684
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Monoclonal Antibodies in the Treatment of Non-Hodgkin’s Lymphoma

  2012cited by this paper
• Regulatory T cells and skin tumors.

  2010cited by this paper
• Prognostic biomarkers in malignant lymphomas

  2010cited by this paper
• The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation.

  2010influential reference
• Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation

  2010cited by this paper
• The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape

  2010cited by this paper
• Malignant B cells skew the balance of regulatory T cells and TH17 cells in B-cell non-Hodgkin's lymphoma.

  2009influential reference
• Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting.

  2009cited by this paper
• B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells.

  2009cited by this paper
• Clinicobiological, prognostic and therapeutic implications of the tumor microenvironment in follicular lymphoma

  2009cited by this paper
• High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma.

  2009cited by this paper
• Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin’s lymphoma

  2008cited by this paper
• Stromal gene signatures in large-B-cell lymphomas.

  2008cited by this paper
• Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling.

  2008influential reference
• High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial.

  2008cited by this paper
• IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.

  2008cited by this paper
• Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma.

  2008cited by this paper
• CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-κB Activation and Up-Regulation of c-FLIP and Bcl-xL1

  2008influential reference
• Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

  2008cited by this paper
• Stroma-initiated hedgehog signaling takes center stage in B-cell lymphoma.

  2008cited by this paper
• Fibroblastic Reticular Cells Guide T Lymphocyte Entry into and Migration within the Splenic T Cell Zone1

  2008cited by this paper
• Classification of lymphoid neoplasms: the microscope as a tool for disease discovery.

  2008cited by this paper
• Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma.

  2007cited by this paper
• Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.

  2007cited by this paper
• CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells.

  2007influential reference
• Absence of a relationship between immunophenotypic and colony enumeration analysis of endothelial progenitor cells in clinical haematopoietic cell sources

  2007cited by this paper
• Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.

  2007cited by this paper
• CD8+ T-Cell Content in Diagnostic Lymph Nodes Measured by Flow Cytometry Is a Predictor of Survival in Follicular Lymphoma

  2007cited by this paper
• A High Tumor-Associated Macrophage Content Predicts Favorable Outcome in Follicular Lymphoma Patients Treated with Rituximab and Cyclophosphamide-Doxorubicin-Vincristine-Prednisone

  2007cited by this paper
• Essential role of stromally induced hedgehog signaling in B-cell malignancies

  2007influential reference
• High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma.

  2006cited by this paper
• Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients.

  2006influential reference
• FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.

  2006cited by this paper
• Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin's lymphoma.

  2006cited by this paper
• Regulatory T cells in cancer.

  2006cited by this paper
• Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L

  2006cited by this paper
• Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome.

  2006cited by this paper
• Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.

  2006influential reference
• In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity.

  2006cited by this paper
• Differential gene expression in non‐malignant tumour microenvironment is associated with outcome in follicular lymphoma patients treated with rituximab and CHOP

  2006cited by this paper
• Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma.

  2005cited by this paper
• CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer.

  2005cited by this paper
• Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL).

  2005cited by this paper
• Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

  2005cited by this paper
• BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors.

  2005cited by this paper
• Follicular Dendritic Cells Catalyze Hepatocyte Growth Factor (HGF) Activation in the Germinal Center Microenvironment by Secreting the Serine Protease HGF Activator

  2005cited by this paper
• How do follicular dendritic cells interact intimately with B cells in the germinal centre?

  2005cited by this paper
• Maintenance of serum antibody levels.

  2005cited by this paper
• Lymph Node Fibroblastic Reticular Cells Construct the Stromal Reticulum via Contact with Lymphocytes

  2004cited by this paper
• Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

  2004cited by this paper
• Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.

  2004cited by this paper
• MALT lymphoma: from morphology to molecules

  2004cited by this paper
• BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.

  2004cited by this paper
• A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.

  2004cited by this paper
• Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells.

  2004cited by this paper
• Lymphocyte trafficking across high endothelial venules: dogmas and enigmas

  2004cited by this paper
• Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer

  2004cited by this paper
• Anti-tumor immunity and autoimmunity: a balancing act of regulatory T cells

  2004cited by this paper
• Supporting Online Material

  2003cited by this paper
• Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma.

  2003cited by this paper
• Kinetics and signaling requirements of CD40‐mediated protection from B cell receptor‐induced apoptosis

  2003cited by this paper
• CXCL13 (BCA‐1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells

  2002cited by this paper
• Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.

  2002cited by this paper
• Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

  2002cited by this paper
• Splenic T Zone Development Is B Cell Dependent

  2001cited by this paper
• New approaches to lymphoma diagnosis.

  2001influential reference
• A chemokine-driven positive feedback loop organizes lymphoid follicles

  2000cited by this paper
• Follicular stromal cells and lymphocyte homing to follicles

  2000cited by this paper
• Factors that predict chemotherapy-induced myelosuppression in lymphoma patients: role of the tumor necrosis factor ligand-receptor system.

  2000cited by this paper
• Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells

  1999cited by this paper
• CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.

  1999cited by this paper
• Somatic hypermutation in normal and transformed human B cells

  1998cited by this paper
• A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4.

  1998cited by this paper
• Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis.

  1998cited by this paper
• Turning off follicular dendritic cells

  1998cited by this paper
• Localization in situ of costimulatory molecules and cytokines in B‐cell non‐Hodgkin’s lymphoma

  1998cited by this paper
• Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

  1997cited by this paper
• In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation.

  1997cited by this paper
• Paracrine Regulation of Germinal Center B Cell Adhesion through the c-Met–Hepatocyte Growth Factor/Scatter Factor Pathway

  1997cited by this paper
• Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation.

  1996cited by this paper
• CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease.

  1995cited by this paper
• Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

  1994cited by this paper
• Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.

  1993cited by this paper
• Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system.

  1993cited by this paper
• Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

  1992cited by this paper
• Follicular lymphoma: a model of lymphoid tumor progression in man.

  1991cited by this paper
• Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clones.

  1990cited by this paper
• Dendritic reticulum cell pattern as a microenvironmental indicator for a distinct origin of lymphoma of follicular mantle cells

  1988influential reference
• Brief Definitive Report Identification of a Human Follicular Dendritic Cell Molecule That Stimulates Germinal Center B Cell Growth

  year unknowncited by this paper

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• The B cell receptor in marginal zone lymphoma ontogeny and evolution

  2020cites this paper
• PD1 distribution pattern, regardless of the cell origin, is an independent microenvironmental prognostic factor for progression-free survival in follicular lymphoma.

  2020cites this paper
• High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma

  2020cites this paper
• Unravelling the proteome of diffuse large B-cell lymphoma: Differences in cell of origin and HLA loss

  2019cites this paper
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  2019cites this paper
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• C-X-C Chemokine Receptor 4 in Diffuse Large B Cell Lymphoma: Achievements and Challenges

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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Establishment and characterization of therapy-resistant mantle cell lymphoma cell lines derived from diff erent tissue sites

  2012cites this paper
• Mechanisms of microenvironmental conditioning in non-Hodgkin’s lymphoma

  2012influential citation
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  2012cites this paper
• Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study.

  2012cites this paper
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  2012cites this paper
• Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications.

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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