Aberrant Salience? Brain Hyperactivation in Response to Pain Onset and Offset in Fibromyalgia

While much brain research on fibromyalgia (FM) focuses on the study of hyperresponsiveness to painful stimuli, some studies suggest that the increased pain‐related brain activity often reported in FM studies may be partially explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, the stimulation's painfulness. Therefore, this study was undertaken to test our hypothesis that FM patients would demonstrate elevated brain responses to both pain onset and offset—2 salient sensory events of opposing valences.

• Publication year

  2020

• Venue

  Arthritis & Rheumatology

• Publication date

  2020-02-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/art.41220PMID 32017421PMCID PMC7329624
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation.

  2019cited by this paper
• Catastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia

  2018cited by this paper
• Encoding of Self‐Referential Pain Catastrophizing in the Posterior Cingulate Cortex in Fibromyalgia

  2018cited by this paper
• The Dorsolateral Prefrontal Cortex in Acute and Chronic Pain.

  2017cited by this paper
• Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe.

  2017cited by this paper
• A comprehensive review of group level model performance in the presence of heteroscedasticity: Can a single model control Type I errors in the presence of outliers?

  2017cited by this paper
• Towards a neurophysiological signature for fibromyalgia

  2017cited by this paper
• Effects of Cognitive-Behavioral Therapy (CBT) on Brain Connectivity Supporting Catastrophizing in Fibromyalgia

  2016cited by this paper
• The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients.

  2015cited by this paper
• The somatosensory link : S 1 functional connectivity is altered by sustained pain and associated with clinical / autonomic dysfunction in fibromyalgia

  2015cited by this paper
• The Somatosensory Link in Fibromyalgia: Functional Connectivity of the Primary Somatosensory Cortex Is Altered by Sustained Pain and Is Associated With Clinical/Autonomic Dysfunction

  2015cited by this paper
• Fibromyalgia: a clinical review.

  2014cited by this paper
• Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI.

  2014cited by this paper
• Disrupted Brain Circuitry for Pain‐Related Reward/Punishment in Fibromyalgia

  2014cited by this paper
• Objective evidence that small‐fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia

  2013cited by this paper
• Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans.

  2013cited by this paper
• Prefrontal control of attention to threat

  2013cited by this paper
• Sustained deep‐tissue pain alters functional brain connectivity

  2013cited by this paper
• Small fibre pathology in patients with fibromyalgia syndrome.

  2013cited by this paper
• Optimizing parameter choice for FSL-Brain Extraction Tool (BET) on 3D T1 images in multiple sclerosis

  2012cited by this paper
• Neurobiology Underlying Fibromyalgia Symptoms

  2011cited by this paper
• Multisensory hypersensitivity in women with fibromyalgia: implications for well being and intervention.

  2011cited by this paper
• The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity

  2010cited by this paper
• Perceived intensity and unpleasantness of cutaneous and auditory stimuli: An evaluation of the generalized hypervigilance hypothesis

  2009cited by this paper
• Mapping Brain Response to Pain in Fibromyalgia Patients Using Temporal Analysis of fMRI

  2009cited by this paper
• Accurate and robust brain image alignment using boundary-based registration

  2009cited by this paper
• A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls.

  2008cited by this paper
• Transient and sustained BOLD responses to sustained visual stimulation.

  2008cited by this paper
• Non-linear registration aka Spatial normalisation

  2007cited by this paper
• Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia

  2007cited by this paper
• Individual Differences in the Effects of Perceived Controllability on Pain Perception: Critical Role of the Prefrontal Cortex

  2007cited by this paper
• The cerebral signature for pain perception and its modulation.

  2007cited by this paper
• How do we know that the pain in fibromyalgia is "real"?

  2006cited by this paper
• Anterolateral Prefrontal Cortex Mediates the Analgesic Effect of Expected and Perceived Control over Pain

  2006cited by this paper
• Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

  2006cited by this paper
• Intensity dependence of auditory-evoked cortical potentials in fibromyalgia patients: a test of the generalized hypervigilance hypothesis.

  2006cited by this paper
• Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)

  2005cited by this paper
• Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

  2005cited by this paper
• Pain catastrophizing and interpersonal problems: a circumplex analysis of the communal coping model

  2004cited by this paper
• Multilevel linear modelling for FMRI group analysis using Bayesian inference

  2004cited by this paper
• Functional imaging of pain in patients with primary fibromyalgia.

  2004cited by this paper
• Pain catastrophizing and neural responses to pain among persons with fibromyalgia.

  2004cited by this paper
• Validation of the Brief Pain Inventory for chronic nonmalignant pain.

  2004cited by this paper
• Integration of emotion and cognition in the lateral prefrontal cortex

  2002cited by this paper
• Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images

  2002cited by this paper
• Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia.

  2002cited by this paper
• Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data

  2001cited by this paper
• A global optimisation method for robust affine registration of brain images

  2001cited by this paper
• Transient activation during block transition.

  2001cited by this paper
• Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

  2000cited by this paper
• Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?

  1999cited by this paper
• Catastrophizing, pain, and disability in patients with soft‐tissue injuries

  1998cited by this paper
• Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects

  1997cited by this paper
• The Pain Catastrophizing Scale: Development and validation.

  1995influential reference
• Psychosocial Predictors of Outcome in Acute and Subchronic Low Back Trouble

  1995cited by this paper
• The prevalence and characteristics of fibromyalgia in the general population.

  1995cited by this paper
• Coping with rheumatoid arthritis.

  1993cited by this paper
• Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy

  1989cited by this paper
• Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation

  1988cited by this paper

• Exploring the hypothetical role of cerebellar pain prediction errors in fibromyalgia-associated chronic pain.

  2026cites this paper
• Machine learning for the diagnosis of fibromyalgia based on magnetic resonance imaging

  2026cites this paper
• Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans

  2026cites this paper
• Brain Responses during provoked pain in Patients with Chronic Primary Pain: A systematic review and meta-analysis of fMRI studies.

  2026cites this paper
• Multidimensional Effects of Manual Therapy Combined with Pain Neuroscience-Based Sensorimotor Retraining in a Patient with Chronic Neck Pain: A Case Study Using fNIRS

  2025cites this paper
• How does chronic psychosocial distress induce pain? Focus on neuroinflammation and neuroplasticity changes.

  2025cites this paper
• An ALE meta-analysis of pain processing alterations in fibromyalgia: toward an evidence-based process model.

  2025cites this paper
• Descending Pain Modulation in Fibromyalgia: A Short Review of Mechanisms and Biomarkers

  2025cites this paper
• Perceptual Novelty in Tinnitus a Causative Factor for its Persistence. A Stimulus Novelty Based P300 Paradigm on Acute, Chronic, and Non-Tinnitus Controls

  2025influential citation
• Can Gratitude Ease the Burden of Fibromyalgia? A Systematic Review

  2025cites this paper
• Does practice make perfect? Functional connectivity of the salience network and somatosensory network predicts response to mind–body treatments for fibromyalgia

  2024cites this paper
• Gender Differences in Amplitude of Low-Frequency Fluctuation Alterations in Healthy Volunteers by Acupuncture on Left “LI 15”: A Resting-State fMRI Study

  2024cites this paper
• Diagnosis and treatment of Fibromyalgia: a comprehensive review of current evidence and clinical practices

  2024cites this paper
• Frequency of idiopathic intracranial hypertension with ultrasound in patients with fibromyalgia: Relation with function, central sensitization, and neuropathic pain

  2024cites this paper
• Neurophysiological and Psychosocial Mechanisms of Fibromyalgia: A Comprehensive Review and Call for An Integrative Model.

  2023cites this paper
• Dysfunctional Activation of the Dorsolateral Prefrontal Cortex During Pain Anticipation Is Associated With Altered Subsequent Pain Experience in Fibromyalgia Patients.

  2023cites this paper
• The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence

  2022cites this paper
• The Lumping/Splitting Conversation Related to Fibromyalgia in Rheumatology: Does It Matter?

  2022cites this paper
• Efficacy of adding pain neuroscience education to a multimodal treatment in fibromyalgia: A systematic review and meta‐analysis

  2022cites this paper
• Research in Mindfulness Interventions for Patients With Fibromyalgia: A Critical Review

  2022cites this paper
• Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

  2021cites this paper
• Fibromyalgia Detection Based on EEG Connectivity Patterns

  2021cites this paper
• Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis

  2021cites this paper
• Involvement of Parvalbumin-Positive Neurons in the Development of Hyperalgesia in a Mouse Model of Fibromyalgia

  2021cites this paper
• 3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia

  2021cites this paper
• How fMRI Analysis Using Structural Equation Modeling Techniques Can Improve Our Understanding of Pain Processing in Fibromyalgia

  2021cites this paper
• Dynamic Functional Brain Connectivity Underlying Temporal Summation of Pain in Fibromyalgia

  2021cites this paper
• Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia

  2021cites this paper
• DNA Methylation and Brain‐Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia

  2020cites this paper
• Surface-based Map Plasticity of the Sensorimotor Cortex in Hip Disorder at Local and Extensive Levels: A Resting-state fMRI Study

  2020cites this paper
• Assessing our approach to diagnosing Fibromyalgia

  2020cites this paper