Dmrt genes participate in the development of Cajal‐Retzius cells derived from the cortical hem in the telencephalon

T. Kikkawa,Nobuyuki Sakayori,Hayato Yuuki,Y. Katsuyama,F. Matsuzaki,D. Konno,T. Abe,H. Kiyonari,N. Osumi

Published 2020 in Developmental Dynamics

ABSTRACT

During development, Cajal‐Retzius (CR) cells are the first generated and essential pioneering neurons that control neuronal migration and arealization in the mammalian cortex. CR cells are derived from specific regions within the telencephalon, that is, the pallial septum in the rostromedial cortex, the pallial‐subpallial boundary, and the cortical hem (CH) in the caudomedial cortex. However, the molecular mechanism underlying the generation of CR cell subtypes in distinct regions of origin is poorly understood.

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