Photocatalytic C-F Bond Borylation of Polyfluoroarenes with NHC-boranes.

The first photoredox-catalyzed defluoroborylation of polyfluoroarenes with NHC-BH3 has been facilely achieved at room temperature via a single-electron-transfer (SET)/radical addition pathway. This new strategy makes full use of the advantage of photoredox catalysis to generate the key boryl radical via direct activation of a B-H bond. Good functional group tolerance and high regioselectivity offer this protocol incomparable advantages in preparing a wide array of valuable polyfluoroarylboron compounds. Moreover, both computational and experimental studies were performed to illustrate the reaction mechanism.

• Publication year

  2020

• Venue

  Organic Letters

• Publication date

  2020-02-13

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.0c00020PMID 32052975
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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