Total Synthesis of Dysoxylactam A.

The total synthesis of a potent multi-drug-resistant reverser, dysoxylacatam A (1), was achieved in a highly efficient and stereocontrolled fashion. The highlights of the strategy enlisted an iterative combination of lithiation-borylation tactics including Aggarwal homologation and Matteson homologation, Brown crotylation, Krische allylation, and ring-closing metathesis to forge the macrocycle.

• Publication year

  2020

• Venue

  Organic Letters

• Publication date

  2020-02-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.0c00074PMID 32049538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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