Sanhuang Shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines.

BACKGROUND Sanhuangshu'ai decoction (SH), a traditional Chinese medicine (TCM) prescription, has been safely used to treat diarrhea, dysentery and other inflammatory diseases with little side effect and low cost for thousands of years. However, its mechanism remains elusive. This study was designed to investigate the anti-ulcerative colitis (UC) activity of SH and mechanism by detecting its anti-inflammatory, anti-oxidative, and intervention effects of intestinal flora with the dextran sodium sulfate (DSS)-induced colitis mice. METHODS The DSS-induced colitis mice was orally administered SH for 1 week with 0.8 or 1.6 g kg-1 d-1 dosage. A clinical disease activity score was evaluated daily. The colonic tissues of the mice were collected and prepared to detect its anti-inflammatory, anti-oxidative, intervention effects of intestinal flora and hydrogen peroxide(H2O2) in vivo, cytotoxicity and ROS influencing effects in vitro. Histological colitis severity and expression of cytokines were also determined. RESULTS Oral administration of SH significantly prevented the development of colitis. It reduced the expression of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α in the colon. Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level. Furthermore, SH can prevent the decrease ofLactobacillus sp. and population abundance of intestinal flora caused by DSS. CONCLUSION SH significantly ameliorates the symptoms of DSS-induced colitis mice and the potential mechanism of SH may involve in multiple kinds of metabolic pathway including the regulation of gut microbiota, inflammatory mediators and cytokines.

• Publication year

  2020

• Venue

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

• Publication date

  2020-02-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.biopha.2020.109934PMID 32058214
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

  2019cited by this paper
• New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

  2019cited by this paper
• Acupuncture therapy for the treatment of stable angina pectoris: An updated meta-analysis of randomized controlled trials.

  2019cited by this paper
• Acupuncture for primary trigeminal neuralgia: A systematic review and PRISMA-compliant meta-analysis.

  2019cited by this paper
• Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group.

  2019cited by this paper
• CTGF-mediated ERK signaling pathway influences the inflammatory factors and intestinal flora in ulcerative colitis.

  2019cited by this paper
• Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

  2019cited by this paper
• QingBai decoction regulates intestinal permeability of dextran sulphate sodium‐induced colitis through the modulation of notch and NF‐κB signalling

  2019cited by this paper
• Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group.

  2019cited by this paper
• Inflammatory bowel disease and bipolar disorder: A population-based cross-sectional study.

  2019cited by this paper
• A Comprehensive and Rapid Quality Evaluation Method of Traditional Chinese Medicine Decoction by Integrating UPLC-QTOF-MS and UFLC-QQQ-MS and Its Application

  2019cited by this paper
• Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.

  2019cited by this paper
• Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: An integrated strategy based on UPLC‐QTOF/MS combined with multivariate statistical analysis

  2019cited by this paper
• Manual Acupuncture for Optic Atrophy: A Systematic Review and Meta-Analysis

  2019cited by this paper
• Preparation of Herbal Formulation for Inflammatory Bowel Disease Based on In Vitro Screening and In Vivo Evaluation in a Mouse Model of Experimental Colitis

  2019cited by this paper
• Eupatilin ameliorates dextran sulphate sodium-induced colitis in mice partly through promoting AMPK activation.

  2018cited by this paper
• Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences

  2018cited by this paper
• Regulation of JAK2/STAT3 and NF-κB signal transduction pathways; Veronica polita alleviates dextran sulfate sodium-induced murine colitis.

  2018cited by this paper
• Dietary Supplementation With a Bacillus Superoxide Dismutase Protects Against &ggr;-Radiation-induced Oxidative Stress and Ameliorates Dextran Sulphate Sodium-induced Ulcerative Colitis in Mice

  2018cited by this paper
• Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis

  2018cited by this paper
• Precision editing of the gut microbiota ameliorates colitis

  2018cited by this paper
• NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice.

  2018cited by this paper
• The role of diet in the aetiopathogenesis of inflammatory bowel disease

  2018cited by this paper
• Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease.

  2017cited by this paper
• Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications

  2017cited by this paper
• The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation

  2017cited by this paper
• Pouchitis after ileal pouch‐anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence

  2017cited by this paper
• Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

  2017cited by this paper
• Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease

  2017cited by this paper
• Chemically induced mouse models of acute and chronic intestinal inflammation

  2017cited by this paper
• Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease

  2017cited by this paper
• The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.

  2017cited by this paper
• Effect of Adalimumab on Clinical Outcomes and Health-related Quality of Life Among Patients With Ulcerative Colitis in a Clinical Practice Setting: Results From InspirADA

  2016cited by this paper
• Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-κB signaling and enhancing antioxidant effect.

  2016cited by this paper
• The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.

  2016cited by this paper
• Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review

  2016cited by this paper
• Gut microbiota role in irritable bowel syndrome: New therapeutic strategies.

  2016cited by this paper
• Nobel Prize for artemisinin brings phytotherapy into the spotlight.

  2015cited by this paper
• Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

  2015cited by this paper
• Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis.

  2015cited by this paper
• The discovery of artemisinin and the Nobel Prize in Physiology or Medicine

  2015cited by this paper
• H2O2 Production in Species of the Lactobacillus acidophilus Group: a Central Role for a Novel NADH-Dependent Flavin Reductase

  2014cited by this paper
• Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.

  2014cited by this paper
• Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific

  2014cited by this paper
• Intestinal Colonization by a Lachnospiraceae Bacterium Contributes to the Development of Diabetes in Obese Mice

  2014cited by this paper
• Considerations of Traditional Chinese Medicine as Adjunct Therapy in the Management of Ulcerative Colitis

  2013cited by this paper
• Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox‐mediated generation of reactive oxygen species

  2013cited by this paper
• Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

  2013cited by this paper
• Ulcerative colitis

  2012cited by this paper
• Herbal Medicine in the Treatment of Ulcerative Colitis

  2012cited by this paper
• New therapies for inflammatory bowel disease: from the bench to the bedside

  2011cited by this paper
• The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

  2011cited by this paper
• Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

  2010cited by this paper
• Biosynthesis and Degradation of H2O2 by Vaginal Lactobacilli

  2009cited by this paper
• Comparison of the Enteric Mucosal Immunomodulatory Activity of Combinations of Coptis chinensis Franch. Rhizomes and Evodia rutaecarpa (Juss.) Benth. Fruits in Mice with Dextran Sulphate Sodium-Induced Ulcerative Colitis

  2009cited by this paper
• Therapeutic potency of IL2–caspase 3 targeted treatment in a murine experimental model of inflammatory bowel disease

  2008cited by this paper
• Quality of life of patients with ulcerative colitis: Past, present, and future

  2008cited by this paper
• Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

  2008cited by this paper
• Inflammatory bowel disease: clinical aspects and established and evolving therapies

  2007cited by this paper
• Effects of Ginkgo biloba Extract on Inflammatory Mediators (SOD, MDA, TNF-α, NF-κBp65, IL-6) in TNBS-Induced Colitis in Rats

  2006cited by this paper
• High-throughput determination of malondialdehyde in plant tissues.

  2005cited by this paper
• Myeloperoxidase: friend and foe

  2005cited by this paper
• Determinants of Life Satisfaction in Inflammatory Bowel Disease

  2005cited by this paper
• Maintenance of remission in ulcerative colitis

  2002cited by this paper
• Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.

  1997cited by this paper
• ULCERATIVE colitis.

  1997cited by this paper
• Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation*

  1997cited by this paper
• [Ulcerative colitis].

  1958cited by this paper

• Alleviation of Ulcerative Colitis in Mice by Individual Fermentation of Periplaneta americana Powder with L. bulgaricus SN22 and S. thermophilus SN05.

  2026cites this paper
• Efficacy of Dietary Supplementation in the Relief of Inflammatory Bowel Disease: A Systematic Review of Animal Studies.

  2025cites this paper
• Exploring the Bioactive Constituents and Therapeutic Mechanisms of Sanhuang Xiexin Decoction in Hypercholesterolemia Treatment Using UHPLC‐Q‐Orbitrap‐MS/MS Integrated With Metabolomics and Network Pharmacology

  2025cites this paper
• Comparison of four characteristic carotenoids (lutein, β-carotene, lycopene, and astaxanthin) in alleviating DSS-induced colitis through gut microbiota regulation.

  2025cites this paper
• Traditional wisdom meets modern science: The protective role of sanhuang shu'ai decoction in ulcerative colitis models.

  2025cites this paper
• [2,6-dimethoxy-1,4-benzoquinone alleviates dextran sulfate sodium-induced ulcerative colitis in mice by suppressing NLRP3 inflammasome activation].

  2025cites this paper
• Potential application mechanism of traditional Chinese medicine in treating immune checkpoint inhibitor-induced colitis

  2024cites this paper
• Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?

  2024cites this paper
• Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis

  2024cites this paper
• Lactiplantibacillus plantarum NMGL2 exopolysaccharide ameliorates DSS-induced IBD in mice mainly by regulation of intestinal tight junction and NF-κB p65 protein expression

  2024cites this paper
• Fermented Soymilk with Probiotic Lactobacilli and Bifidobacterium Strains Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Rats

  2024cites this paper
• Fagopyrum cymosum alleviates DSS-induced colitis via ameliorating intestinal barrier function and remolding gut microbiota

  2024cites this paper
• Fuzi Lizhong Pills alter microbial community compositions and metabolite profiles in ulcerative colitis rat with Spleen-Kidney Yang Deficiency Syndrome.

  2024cites this paper
• Traditional Chinese medicine treats ulcerative colitis by regulating gut microbiota, signaling pathway and cytokine: Future novel method option for pharmacotherapy

  2024cites this paper
• Characterization of Active Compounds in Sanhuang Shu'ai Decoction for the Management of Ulcerative Colitis: A UHPLC-MS Study.

  2024cites this paper
• Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice

  2023cites this paper
• Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice

  2023cites this paper
• Traditional Chinese Medicine: A promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology.

  2023cites this paper
• Jianpi Yangzheng decoction suppresses gastric cancer progression via modulating the miR-448/CLDN18.2 mediated YAP/TAZ signaling.

  2023cites this paper
• Qingre Xingyu recipe exerts inhibiting effects on ulcerative colitis development by inhibiting TNFα/NLRP3/Caspase-1/IL-1β pathway and macrophage M1 polarization

  2023cites this paper
• Animal models of inflammatory bowel disease: category and evaluation indexes

  2023cites this paper
• Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.

  2023cites this paper
• Repairing the intestinal mucosal barrier of traditional Chinese medicine for ulcerative colitis: a review

  2023cites this paper
• Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.

  2022cites this paper
• Network pharmacology and in vivo experiment-based strategy to investigate mechanisms of JingFangFuZiLiZhong formula for ulcerative colitis

  2022cites this paper
• Potential activity of Traditional Chinese Medicine against Ulcerative colitis: A review.

  2022cites this paper
• Long-term maternal intake of inulin exacerbated the intestinal damage and inflammation of offspring rats in a DSS-induced colitis model.

  2022cites this paper
• Artemisia argyi extract alleviates inflammation in a DSS-induced colitis mouse model and enhances immunomodulatory effects in lymphoid tissues

  2022cites this paper
• Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway

  2022cites this paper
• Effects of the Traditional Chinese Medicine Formula Ento-PB in Experimental Models of Ulcerative Colitis

  2022influential citation
• Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites

  2022cites this paper
• Holism of Chinese herbal medicine prescriptions for inflammatory bowel disease: A review based on clinical evidence and experimental research.

  2022cites this paper
• Exopolysaccharide from Lactobacillus rhamnosus ZFM231 alleviates DSS-induced colitis in mice by regulating gut microbiota.

  2022cites this paper
• Inflammatory bowel disease: an overview of Chinese herbal medicine formula-based treatment

  2022cites this paper
• The Ameliorating Effect of Lizhong-Tang on Antibiotic-Associated Imbalance in the Gut Microbiota in Mouse

  2022cites this paper
• Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis

  2022cites this paper
• Cocultivation of Chinese prescription and intestine microbiota: SJZD alleviated the major symptoms of IBS-D subjects by tuning neurotransmitter metabolism

  2022cites this paper
• Metabolomics Study of Shaoyao Plants Decoction on the Proximal and Distal Colon in Mice with Dextran Sulfate Sodium-Induced Colitis by UPLC-Q-TOF-MS

  2022cites this paper
• Gut microbiota and transcriptome profiling revealed the protective effect of aqueous extract of Tetrastigma hemsleyanum leaves on ulcerative colitis in mice

  2022cites this paper
• Intestinal Flora: A Pivotal Role in Investigation of Traditional Chinese Medicine.

  2021cites this paper
• Bene�cial role of Pistacia lentiscus aqueous extract in experimental colitis: Anti-in�ammatory and potential therapeutic effects

  2021cites this paper
• Capparis spinosa Alleviates DSS-Induced Ulcerative Colitis via Regulation of the Gut Microbiota and Oxidative Stress

  2021cites this paper
• The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

  2021cites this paper
• A Mixture of Lactobacillus fermentum HFY06 and Arabinoxylan Ameliorates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice

  2021cites this paper
• p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

  2021cites this paper
• Potential of phytomedicine in the treatment of inflammatory bowel disease

  2021cites this paper
• Efficient Stool Collection Methods for Evaluating the Diarrhea Score in Mouse Diarrhea Models

  2021cites this paper
• Beneficial role of Pistacia lentiscus aqueous extract in experimental colitis: anti-inflammatory and potential therapeutic effects

  2021cites this paper
• Mechanisms of traditional Chinese medicine in modulating gut microbiota metabolites-mediated lipid metabolism.

  2021cites this paper
• New discovery of anti-ulcerative colitis active ingredients of Nostoc commune: p-Hydroxy benzaldehyde

  2021cites this paper
• The dietary supplement Rhodiola crenulata extract alleviates dextran sulfate sodium-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the gut microbiome.

  2021cites this paper
• Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5.

  2021cites this paper
• The comparison of extraction methods of ganjiang decoction based on fingerprint, quantitative analysis and pharmacodynamics

  2020cites this paper
• A Review of the Effects of Natural Compounds, Medicinal Plants, and Mushrooms on the Gut Microbiota in Colitis and Cancer

  2020cites this paper
• Pingkui Enema Alleviates TNBS-Induced Ulcerative Colitis by Regulation of Inflammatory Factors, Gut Bifidobacterium, and Intestinal Mucosal Barrier in Rats

  2020cites this paper
• Efficacy of Shenfu decoction on sepsis in rats with condition in- duced by cecal ligation and puncture

  2020cites this paper
• Traditional Chinese medicine in modulating gut microbiota across major disease systems: a review

  year unknowncites this paper