Repair of DNA damage induced by the novel nucleoside analogue CNDAG through homologous recombination

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Cancer Chemotherapy and Pharmacology

• Publication date

  2020-02-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00280-020-04035-xPMID 32072218
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations

  2018cited by this paper
• Abstract 962: Mechanism-based drug combinations with the DNA-strand-breaking nucleoside analog CNDAC

  2011cited by this paper
• Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.

  2010cited by this paper
• ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

  2009cited by this paper
• 9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

  2009cited by this paper
• Nucleoside analogs: molecular mechanisms signaling cell death

  2008cited by this paper
• FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma.

  2008cited by this paper
• Nelarabine

  2008cited by this paper
• Radiation Enhances Caspase 3 Cleavage of Rad51 in BRCA2-Defective Cells

  2008cited by this paper
• Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.

  2008cited by this paper
• 9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.

  2007cited by this paper
• Molecular mechanisms of sister-chromatid exchange.

  2007cited by this paper
• Clofarabine and nelarabine: two new purine nucleoside analogs

  2006cited by this paper
• The Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog Activation

  2006cited by this paper
• Nelarabine

  2006cited by this paper
• Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.

  2005cited by this paper
• Nelarabine: A Nucleoside Analog with Efficacy in T-Cell and other Leukemias

  2005cited by this paper
• ATM gene and lymphoid malignancies

  2004cited by this paper
• Molecular variants of the ATM gene in Hodgkin's disease in children

  2004cited by this paper
• Mechanisms for T-cell selective cytotoxicity of arabinosylguanine.

  2003cited by this paper
• Structure of human dCK suggests strategies to improve anticancer and antiviral therapy

  2003cited by this paper
• BRCA2 and homologous recombination

  2001cited by this paper
• Homologous recombinational repair of DNA ensures mammalian chromosome stability.

  2001cited by this paper
• Frameshift Mutation in PRKDC, the Gene for DNA-PKcs, in the DNA Repair-Defective, Human, Glioma-Derived Cell Line M059J

  2001cited by this paper
• 2′-C-Cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine: A Novel Anticancer Nucleoside Analog that Causes Both DNA Strand Breaks and G2 Arrest

  2001cited by this paper
• DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining

  2000cited by this paper
• The controlling role of ATM in homologous recombinational repair of DNA damage

  2000cited by this paper
• Human TP53 from the Malignant Glioma-Derived Cell Lines M059J and M059K Has a Cancer-Associated Mutation in Exon 8

  2000cited by this paper
• XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

  1999cited by this paper
• Stereoisomeric selectivity of human deoxyribonucleoside kinases.

  1999cited by this paper
• Enhanced Cytotoxicity of Nucleoside Analogs by Overexpression of Mitochondrial Deoxyguanosine Kinase in Cancer Cell Lines*

  1998cited by this paper
• The ATM gene and susceptibility to childhood T‐cell acute lymphoblastic leukaemia

  1998cited by this paper
• Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase.

  1998cited by this paper
• Recombinant ATM protein complements the cellular A-T phenotype

  1997cited by this paper
• Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells.

  1995cited by this paper
• Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

  1995cited by this paper
• DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene.

  1995influential reference
• 2′-C-Cyano-2′-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC): A Mechanism-Based DNA-Strand-Breaking Antitumor Nucleoside1

  1995cited by this paper
• Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.

  1993cited by this paper
• Mutations of the p53 gene in adult T-cell leukemia.

  1992cited by this paper
• Nucleosides and nucleotides. 100. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosyl-cytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside.

  1991cited by this paper
• Differential metabolism of 9-β-D-arabinofuranosylguanine in human leukemic cells

  1989cited by this paper
• Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells.

  1989cited by this paper
• Metabolism and selective cytotoxicity of 9-beta-D-arabinofuranosylguanine in human lymphoblasts.

  1985cited by this paper
• Nucleosides and Nucleotides

  1979cited by this paper

• Protective Effect of Follicle-Stimulating Hormone on DNA Damage of Chicken Follicular Granulosa Cells by Inhibiting CHK2/p53

  2022cites this paper
• Unfolding New Roles for Guanine-Based Purines and Their Metabolizing Enzymes in Cancer and Aging Disorders

  2021cites this paper
• of radioresistance in glioblastoma stem-like

  year unknowncites this paper