The DNA-damaging potential of tamoxifen in breast cancer and normal cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Archives of Toxicology

• Publication date

  2007-02-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00204-007-0188-3PMID 17593413
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
• The role of oxidative stress in developmental and reproductive toxicity of tamoxifen.

  2001cited by this paper
• Amifostine: Mechanisms of Action Underlying Cytoprotection and Chemoprevention

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• DNA glycosylases in the base excision repair of DNA.

  1997cited by this paper
• Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching.

  1997influential reference
• The comet assay: mechanisms and technical considerations.

  1996cited by this paper
• Cancer risk and oxidative DNA damage in man

  1996cited by this paper
• The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment.

  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA.

  1993cited by this paper
• Induction of covalent DNA adducts in rodents by tamoxifen.

  1992cited by this paper
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  1988cited by this paper

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  2021cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
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  2013cites this paper
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