Zinc Chloride Protects against Streptozotocin-Induced Diabetic Nephropathy in Rats

Diabetes mellitus (DM) is a health problem affecting millions of individuals worldwide. Diabetic nephropathy (DN), as a significant complication of DM, has become the most common cause of endstage renal failure. Oxidative stress constitutes the key and common events in the pathogenesis of DN and antioxidants may play a beneficial role in its prevention. This study was conducted to investigate the effect of Zinc Chloride on streptozotocin-induced diabetic nephropathy in rats compared to Gliclazide, a reference antidiabetic agent. Results showed that Zinc Chloride was able to control STZ-induced DN in rats as it normalized the elevated blood pressure, the increased insulin release, and the decreased blood glucose level. Zinc Chloride also improved kidney function as determined by the restoration of blood urea and creatinine level. Finally, Zinc Chloride was able to boost the antioxidant defenses of the kidney by increasing the reduced glutathione content and decreasing lipid peroxides content in addition to significantly decreasing kidney nitric oxide content compared to diabetic control rats. These results suggest that exposure to Zinc Chloride can protect from diabetic nephropathy and can be used as an adjuvant approach to treatment and prevention of renal damage.

• Publication year

  2016

• Venue

  Pharmacology & Pharmacy

• Publication date

  2016-08-04

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.4236/PP.2016.78041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
• Biochemical and Histopathological Investigation of Resveratrol, Gliclazide, and Losartan Protective Effects on Renal Damage in a Diabetic Rat Model.

  2015cited by this paper
• Knockout of the TauT Gene Predisposes C57BL/6 Mice to Streptozotocin-Induced Diabetic Nephropathy

  2015cited by this paper
• Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition

  2014cited by this paper
• The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: The “Gift” That Keeps on Giving!

  2013cited by this paper
• Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy.

  2012cited by this paper
• Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats

  2012cited by this paper
• Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.

  2012cited by this paper
• Zinc, Copper, Iron, and Chromium Concentrations in Young Patients with Type 2 Diabetes Mellitus

  2012cited by this paper
• Comparative effects of zinc, selenium and vitamin E or their combination on carbohydrate metabolizing enzymes and oxidative stress in streptozotocin induced-diabetic rats.

  2012influential reference
• Reactive oxygen species and insulin resistance: the good, the bad and the ugly.

  2011cited by this paper
• Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling.

  2011cited by this paper
• Impaired Mitochondrial Respiratory Functions and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

  2011cited by this paper
• Attenuation of renal dysfunction by anti-hyperglycemic compound isolated from fruit pulp of Eugenia jambolana in streptozotocin-induced diabetic rats.

  2010cited by this paper
• Global estimates of the prevalence of diabetes for 2010 and 2030.

  2010cited by this paper
• An iron-based cytosolic catalase and superoxide dismutase mimic complex.

  2010cited by this paper
• Oxidative stress, nitric oxide, and diabetes.

  2010cited by this paper
• Zinc and diabetes--clinical links and molecular mechanisms.

  2009cited by this paper
• Reactive oxygen‐derived free radicals are key to the endothelial dysfunction of diabetes

  2009cited by this paper
• Diabetes, oxidative stress, nitric oxide and mitochondria function.

  2009cited by this paper
• Polyphenolic Extract of Ichnocarpus Frutescens Attenuates Diabetic Complications in Streptozotocin-Treated Diabetic Rats

  2008cited by this paper
• Zinc status and dietary quality of type 2 diabetic patients: implication of physical activity level

  2008cited by this paper
• Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis.

  2008cited by this paper
• Copper, Chromium, Manganese, Iron, Nickel, and Zinc Levels in Biological Samples of Diabetes Mellitus Patients

  2008cited by this paper
• Artemisia asiatica extracts protect against ethanol‐induced injury in gastric mucosa of rats

  2008cited by this paper
• Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.

  2006cited by this paper
• Red wine prevents brain oxidative stress and nephropathy in streptozotocin-induced diabetic rats.

  2005cited by this paper
• Diabète sucré, stress oxydant et produits de glycation avancée

  2004cited by this paper
• [Diabetes mellitus, oxidative stress and advanced glycation endproducts].

  2004cited by this paper
• Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.

  2004cited by this paper
• Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocin-induced diabetic rats.

  2004cited by this paper
• Molecular motors

  2003cited by this paper
• Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes

  2003cited by this paper
• Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.

  2002cited by this paper
• Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.

  2002cited by this paper
• The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes.

  2001cited by this paper
• Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin.

  2001cited by this paper
• Differential Sensitivity of GLUT1- and GLUT2-Expressing β Cells to Streptozotocin

  2001cited by this paper
• Spectrum of renal diseases in Indian adults.

  2000cited by this paper
• Effects of Dietary Supplementation of a -Lipoic Acid on Early Glomerular Injury in Diabetes Mellitus

  2000cited by this paper
• Long-term effects of the endothelin(A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model.

  2000cited by this paper
• Reversal of lesions of diabetic nephropathy after pancreas transplantation.

  1998cited by this paper
• Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions : implication for glycoxidative stress in the pathogenesis of diabetic nephropathy

  1998cited by this paper
• Effects of glibenclamide on blood pressure and cardiovascular responsiveness in non‐insulin dependent diabetes mellitus

  1998cited by this paper
• Prevention of decline in renal function in the diabetic db/db mouse

  1996cited by this paper
• Morphometric detection of incipient glomerular lesions in diabetic nephropathy in rats. Protective effects of ACE inhibition.

  1995cited by this paper
• Effects of glibenclamide on systemic and splanchnic haemodynamics in conscious rats

  1994cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

  1979cited by this paper
• Metal sites of copper-zinc superoxide dismutase.

  1977cited by this paper
• Selenium: Biochemical Role as a Component of Glutathione Peroxidase

  1973cited by this paper
• Tissue sulfhydryl groups.

  1959cited by this paper

• Antioxidants used in Streptozotocin Induced Diabetic Nephropathy: A Concise Review

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  2023cites this paper
• The impact of zinc on the molecular signaling pathways in the diabetes disease.

  2022cites this paper
• Investigation of the impacts of zamzam water on streptozotocin-induced diabetic nephropathy in rats. In-vivo and in-vitro study.

  2021cites this paper
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  2020cites this paper
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  2019cites this paper
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  2017cites this paper