Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Biomedical Materials Research. Part A

• Publication date

  2008-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/JBM.A.31760PMID 18085655
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.

  2007cited by this paper
• Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization

  2006cited by this paper
• PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles

  2005cited by this paper
• Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

  2005cited by this paper
• Tumor Cell Killing Enabled by Listeriolysin O-liposome-mediated Delivery of the Protein Toxin Gelonin*

  2003cited by this paper
• Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes*

  2003cited by this paper
• Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves.

  2003cited by this paper
• The Cytotoxic Activity of Ribosome-inactivating Protein Saporin-6 Is Attributed to Its rRNA N-Glycosidase and Internucleosomal DNA Fragmentation Activities*

  2003cited by this paper
• Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase.

  2003cited by this paper
• Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy

  2002cited by this paper
• Molecular targeting of the epidermal growth factor receptor for neutron capture therapy of gliomas.

  2002cited by this paper
• Prevention of influenza pneumonitis by sialic Acid-conjugated dendritic polymers.

  2002cited by this paper
• Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16INK4A, and p19ARF genes in nasopharyngeal carcinoma

  2002cited by this paper
• Dendritic polymer macromolecular carriers for drug delivery.

  2002cited by this paper
• Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates.

  2002cited by this paper
• Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications.

  2001cited by this paper
• Polyethylenimine‐mediated gene delivery: a mechanistic study

  2001cited by this paper
• NUCLEAR DAMAGE INDUCED BY LIPOSOMES CONTAINING FITC-LABELLED SAPORIN ON HUMAN MELANOMA CELLS IN VITRO

  2001cited by this paper
• Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin

  2001cited by this paper
• Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31‐gelonin

  2000cited by this paper
• Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells.

  2000cited by this paper
• Efficacy of the chemotherapeutic action of HPMA copolymer‐bound doxorubicin in a solid tumor model of ovarian carcinoma

  2000cited by this paper
• Endocytosis of a chimera between human pro‐urokinase and the plant toxin saporin: an unusual internalization mechanism

  2000cited by this paper
• Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization.

  2000cited by this paper
• Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

  2000cited by this paper
• Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells

  1999cited by this paper
• Shock wave permeabilization with ribosome inactivating proteins: a new approach to tumor therapy.

  1999cited by this paper
• Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.

  1999cited by this paper
• Pokeweed antiviral protein cleaves double-stranded supercoiled DNA using the same active site required to depurinate rRNA.

  1999cited by this paper
• Dendrimer-platinate: a novel approach to cancer chemotherapy.

  1999cited by this paper
• The amino‐terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated

  1997cited by this paper
• Enhancement of immunotoxin activity using chemical and biological reagents.

  1997cited by this paper
• Regulation of protein transport to the nucleus: central role of phosphorylation.

  1996cited by this paper
• Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers.

  1996cited by this paper
• Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma.

  1995cited by this paper
• In vivo and in vitro uptake of an anti‐CD30/saporin immunotoxin by rat liver parenchymal and nonparenchymal cells

  1994cited by this paper
• A new approach in the synthesis of immunotoxins: ribosome inactivating protein noncovalently bound to monoclonal antibody.

  1994cited by this paper
• Distribution and properties of major ribosome-inactivating proteins (28 S rRNA N-glycosidases) of the plant Saponaria officinalis L. (Caryophyllaceae).

  1993cited by this paper
• Ribosome-inactivating proteins from plants.

  1993cited by this paper
• Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor.

  1991cited by this paper
• Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter

  1990cited by this paper
• The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

  1987cited by this paper
• Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors

  1987cited by this paper
• Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture.

  1986cited by this paper
• Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

  1985cited by this paper
• ADP stimulates hydrolysis of the "ADP-insensitive" phosphoenzyme in Na+, K+-ATPase and Ca2+-ATPase.

  1985cited by this paper
• Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.

  1984cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Liposome-mediated delivery of ribosome inactivating proteins to cells in vitro.

  1982cited by this paper
• Cytotoxicity acquired by conjugation of an anti-Thy1.1 monoclonal antibody and the ribosome-inactivating protein, gelonin.

  1981cited by this paper

• Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability

  2024cites this paper
• A bioinspired pseudopeptide-based intracellular delivery platform enhances the cytotoxicity of a ribosome-inactivating protein through multiple death pathways

  2024cites this paper
• Magnetic Nanoparticles in Targeted Drug Delivery: a Review

  2021cites this paper
• Intracellular Delivery: An Overview

  2019cites this paper
• Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids

  2018cites this paper
• Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins

  2018cites this paper
• pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells.

  2018cites this paper
• Non‐covalent formulation of active principles with dendrimers: Current state‐of‐the‐art and prospects for further development

  2017cites this paper
• Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions)

  2017cites this paper
• Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers

  2016cites this paper
• Polymeric Nanocarriers for Treatment of Melanoma and Genetically Modified Mesenchymal Stem Cells to Improve Outcome of Islet Transplantation

  2015cites this paper
• Photochemical internalization of recombinant toxins targeting EGFR and HER2 for treatment of aggressive and resistant cancers

  2015cites this paper
• Nanoparticle-mediated drug delivery for treating melanoma.

  2015cites this paper
• Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation

  2015cites this paper
• Porphine functionalized nanoparticles of star-shaped poly(ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 1000 succinate biodegradable copolymer for chemophotodynamic therapy on cervical cancer.

  2015cites this paper
• Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

  2014cites this paper
• Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment.

  2014cites this paper
• Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicin

  2014cites this paper
• Dendrimer Bioconjugates: Synthesis and Applications

  2014cites this paper
• Development of a platform technology for enhanced endo/lysosomal escape of targeted toxins by structurally specific oleanane saponins

  2014cites this paper
• A Long Journey to the Cytosol

  2014cites this paper
• Subcellular drug targeting, pharmacokinetics and bioavailability

  2014cites this paper
• Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1.

  2013cites this paper
• Light-Controlled Modulation of Gene Expression Using Polyamidoamine Formulations

  2013cites this paper
• Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

  2013cites this paper
• Enhancing nucleic acid delivery by photochemical internalization.

  2013cites this paper
• Photodynamic Drug Delivery

  2012cites this paper
• Degradable Dendrimers for Drug Delivery

  2012cites this paper
• Bifunctional silica-coated superparamagnetic FePt nanoparticles for fluorescence/MR dual imaging

  2012cites this paper
• Why not just switch on the light?: light and its versatile applications in the field of nanomedicine

  2012cites this paper
• Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells.

  2011cites this paper
• Nanoparticles for intracellular-targeted drug delivery

  2011cites this paper
• Overcome the Doxorubicin Resistance by Multimodal Nanoparticles in Mice

  2011cites this paper
• Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver.

  2010cites this paper
• Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules.

  2010cites this paper
• Photochemical internalization: a new tool for gene and oligonucleotide delivery.

  2010cites this paper
• Ricin and Saporin: Plant Enzymes for the Research and the Clinics

  2010cites this paper
• The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines

  2010cites this paper
• Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers.

  2010cites this paper
• Recent progress in research on ribosome inactivating proteins.

  2009cites this paper
• Enhanced Cytotoxicity of Doxorubicin by Micellar Photosensitizer-mediated Photochemical Internalization in Drug-resistant MCF-7 Cells

  2009cites this paper
• Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles.

  2009cites this paper
• Star-Shaped Porphyrin-polylactide Formed Nanoparticles for Chemo-Photodynamic Dual Therapies

  2009cites this paper
• Improved immunotoxins with novel functional elements.

  2009cites this paper
• Self-assembled star-shaped chlorin-core poly(epsilon-caprolactone)-poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies.

  2008cites this paper
• Non-toxic phototriggered gene transfection by PAMAM-porphyrin conjugates.

  2008cites this paper