MAD2 interacts with DNA repair proteins and negatively regulates DNA damage repair.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Molecular Biology

• Publication date

  2008-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jmb.2008.05.080PMID 18597777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour.

  2007cited by this paper
• Protein trafficking in response to DNA damage.

  2007cited by this paper
• Dynamic nuclear pore complexes: life on the edge.

  2006cited by this paper
• XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair.

  2006cited by this paper
• Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells

  2006cited by this paper
• XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells.

  2006cited by this paper
• Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway.

  2006cited by this paper
• DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes.

  2006cited by this paper
• Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agents.

  2006cited by this paper
• Mitotic arrest deficient 2 expression induces chemosensitization to a DNA-damaging agent, cisplatin, in nasopharyngeal carcinoma cells.

  2005cited by this paper
• DNA repair: the importance of phosphorylating histone H2AX.

  2005cited by this paper
• Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

  2004cited by this paper
• Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines

  2004cited by this paper
• Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.

  2004cited by this paper
• Mechanisms of DNA damage recognition and strand discrimination in human nucleotide excision repair.

  2004cited by this paper
• Xpd/Ercc2 regulates CAK activity and mitotic progression

  2003cited by this paper
• The comings and goings of nucleotide excision repair factors on damaged DNA

  2003cited by this paper
• Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines.

  2003cited by this paper
• Overlapping roles of the spindle assembly and DNA damage checkpoints in the cell-cycle response to altered chromosomes in Saccharomyces cerevisiae.

  2002cited by this paper
• Genomic Instability in Mice Lacking Histone H2AX

  2002cited by this paper
• DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint.

  2002cited by this paper
• Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD.

  2002cited by this paper
• Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase.

  2001cited by this paper
• Different dynamics in nuclear entry of subunits of the repair/transcription factor TFIIH.

  2001cited by this paper
• Mechanisms of resistance to cisplatin.

  2001cited by this paper
• The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm.

  2000cited by this paper
• Molecular structure of human TFIIH.

  2000cited by this paper
• Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder

  2000cited by this paper
• Damage recognition in nucleotide excision repair of DNA.

  2000cited by this paper
• A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2*

  2000cited by this paper
• Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells: role of ERCC1-XPF.

  2000cited by this paper
• Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae

  1999cited by this paper
• Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

  1999cited by this paper
• The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

  1998cited by this paper
• Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

  1998cited by this paper
• Role of the human RAD51 protein in homologous recombination and double-stranded-break repair.

  1998cited by this paper
• DNA Damage Recognition by XPA Protein Promotes Efficient Recruitment of Transcription Factor II H*

  1997cited by this paper
• Competent transcription initiation by RNA polymerase II in cell-free extracts from xeroderma pigmentosum groups B and D in an optimized RNA transcription assay.

  1997cited by this paper
• The spindle assembly checkpoint.

  1996cited by this paper
• Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy.

  1996cited by this paper
• The General Transcription-Repair Factor TFIIH Is Recruited to the Excision Repair Complex by the XPA Protein Independent of the TFIIE Transcription Factor (*)

  1995cited by this paper
• The genetic basis of xeroderma pigmentosum.

  1991cited by this paper
• ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3.

  1990cited by this paper

• Phosphorylation of MAD2 at Ser195 Promotes Spindle Checkpoint Defects and Sensitizes Cancer Cells to Radiotherapy in ATM Deficient Cells

  2022cites this paper
• Mitotic and DNA Damage Response Proteins: Maintaining the Genome Stability and Working for the Common Good

  2021cites this paper
• Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer.

  2020cites this paper
• p53 mediates hydroxyurea resistance in aneuploid cells of colon cancer

  2019cites this paper
• Ancestral Eukaryotes Reproduced Asexually, Facilitated by Polyploidy: A Hypothesis

  2019cites this paper
• Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.

  2016cites this paper
• MAD2γ, a novel MAD2 isoform, reduces mitotic arrest and is associated with resistance in testicular germ cell tumors

  2016cites this paper
• Defining the mechanisms of breast tumorigenesis in the context of chromosome instability and oncogene dependence

  2014cites this paper
• Chk1-Mad2 interaction

  2013cites this paper
• Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer

  2012cites this paper
• The kinetochore protein Bub1 participates in the DNA damage response.

  2012influential citation
• Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.

  2011cites this paper
• Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients.

  2011cites this paper
• Depression of MAD2 inhibits apoptosis and increases proliferation and multidrug resistance in gastric cancer cells by regulating the activation of phosphorylated survivin

  2010cites this paper
• The role of aneuploidy in promoting and suppressing tumors

  2009cites this paper
• JCB: COMMENT

  2009cites this paper