Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cell Chemical Biology

• Publication date

  2017-05-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.chembiol.2017.03.014PMID 28434876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials

  2016influential reference
• Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

  2016cited by this paper
• TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

  2016cited by this paper
• Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

  2016influential reference
• A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

  2015influential reference
• Unexpected versatility in bacterial riboswitches.

  2015cited by this paper
• Selective small-molecule inhibition of an RNA structural element

  2015influential reference
• (Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds.

  2015cited by this paper
• Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species

  2015influential reference
• The ribB FMN riboswitch from Escherichia coli operates at the transcriptional and translational level and regulates riboflavin biosynthesis

  2015influential reference
• Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

  2015cited by this paper
• The promise of riboswitches as potential antibacterial drug targets.

  2014cited by this paper
• Rfam 12.0: updates to the RNA families database

  2014cited by this paper
• The flavoenzyme azobenzene reductase AzoR from Escherichia coli binds roseoflavin mononucleotide (RoFMN) with high affinity and is less active in its RoFMN form.

  2013cited by this paper
• Riboflavin analogs as antiinfectives: occurrence, mode of action, metabolism and resistance.

  2013cited by this paper
• A decade of riboswitches.

  2013cited by this paper
• Flavoproteins Are Potential Targets for the Antibiotic Roseoflavin in Escherichia coli

  2013cited by this paper
• Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride

  2012cited by this paper
• A highly specialized flavin mononucleotide riboswitch responds differently to similar ligands and confers roseoflavin resistance to Streptomyces davawensis

  2012cited by this paper
• Rfam 11.0: 10 years of RNA families

  2012cited by this paper
• Rapid determination of vitamin B₂ (riboflavin) in plasma by HPLC.

  2011influential reference
• Prospects for riboswitch discovery and analysis.

  2011cited by this paper
• The Riboflavin analog Roseoflavin targets an FMN-riboswitch and blocks Listeria monocytogenes growth, but also stimulates virulence gene-expression and infection

  2011cited by this paper
• Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

  2010cited by this paper
• Structure and mechanism of the S component of a bacterial ECF transporter

  2010influential reference
• The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.

  2010influential reference
• The RFN riboswitch of Bacillus subtilis is a target for the antibiotic roseoflavin produced by Streptomyces davawensis

  2009influential reference
• Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

  2009cited by this paper
• Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

  2009cited by this paper
• Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

  2009influential reference
• Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression

  2009influential reference
• Characterization of Riboflavin (Vitamin B2) Transport Proteins from Bacillus subtilis and Corynebacterium glutamicum

  2007influential reference
• Riboswitches as antibacterial drug targets

  2006cited by this paper
• Biosynthesis of flavocoenzymes.

  2005cited by this paper
• Biochemical and molecular characterization of an azoreductase from Staphylococcus aureus, a tetrameric NADPH-dependent flavoprotein.

  2005influential reference
• Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors*

  2005cited by this paper
• Regulation of bacterial gene expression by riboswitches.

  2005influential reference
• Thiamine pyrophosphate riboswitches are targets for the antimicrobial compound pyrithiamine.

  2005cited by this paper
• Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing Methicillin-Resistant Staphylococcus epidermidis Strain

  2005cited by this paper
• 3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures.

  2003cited by this paper
• Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria.

  2002influential reference
• Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.

  2002cited by this paper
• An mRNA structure that controls gene expression by binding FMN

  2002influential reference
• A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes.

  1999cited by this paper
• Regulation of Riboflavin Biosynthesis inBacillus subtilis Is Affected by the Activity of the Flavokinase/Flavin Adenine Dinucleotide Synthetase Encoded byribC

  1998influential reference
• Electrotransformation of Staphylococci.

  1995cited by this paper
• Flavokinase and FAD synthetase from Bacillus subtilis specific for reduced flavins.

  1979cited by this paper
• ROSEOFLAVIN, A NEW ANTIMICROBIAL PIGMENT FROM STREPTOMYCES

  1974cited by this paper
• Letter: Roseoflavin, a new antimicrobial pigment from Streptomyces.

  1974cited by this paper
• BIOINFORMATICS ORIGINAL PAPER

  year unknowninfluential reference

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• Site‐Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting

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• Gene Regulation by a Kinetic Riboswitch with Negative Feedback Loop.

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• Application of microbial pigments in the pharmaceutical industry: current status and opportunities

  2025cites this paper
• Deep mutational scanning of an S. pneumoniae FMN riboswitch reveals robustness during mouse infection but diverging adaptive landscapes in response to targeting antibiotics

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• Structural and dynamic properties of guanosine-analog binding to 2′-deoxyguanosine-II riboswitch: a computational study

  2025cites this paper
• Functional analysis of thiamine pyrophosphate-responsive riboswitches in human bacterial pathogens of the ESKAPE group using a dual-luciferase reporter gene assay

  2025cites this paper
• Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum

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• Knotty is nice: Metabolite binding and RNA-mediated gene regulation by the preQ1 riboswitch family

  2024cites this paper
• The Escherichia coli ribB riboswitch senses flavin mononucleotide within a defined transcriptional window

  2024cites this paper
• A Review of Antibacterial Candidates with New Modes of Action

  2024cites this paper
• Isolation, characterisation and description of the roseoflavin producer Streptomyces berlinensis sp. nov.

  2024cites this paper
• RNA cis-regulators are important for Streptococcus pneumoniae in vivo success

  2024cites this paper
• Regulatory RNAs in Bacillus subtilis: A review on regulatory mechanism and applications in synthetic biology

  2024cites this paper
• A sensitive and scalable fluorescence anisotropy single stranded RNA targeting approach for monitoring riboswitch conformational states

  2024cites this paper
• Harnessing Computational Approaches for RNA-Targeted Drug Discovery

  2024cites this paper
• Vitamin derivatives as potential drugs for Influenza Hemagglutinin

  2023cites this paper
• Regulation of bacterial gene expression by non-coding RNA: It is all about time!

  2023cites this paper
• Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids

  2023cites this paper
• Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development

  2023cites this paper
• Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections

  2023cites this paper
• Enzymes in riboflavin biosynthesis: Potential antibiotic drug targets.

  2023cites this paper
• Multidimensional Applications and Challenges of Riboswitches in Biosensing and Biotherapy.

  2023cites this paper
• Efficient production of bacterial antibiotics aminoriboflavin and roseoflavin in eukaryotic microorganisms, yeasts

  2023cites this paper
• Riboswitches as therapeutic targets: promise of a new era of antibiotics

  2023cites this paper
• Mechanistic Insights into Roseoflavin Synthesis by N,N-8-Demethyl-8-aminoriboflavin Dimethyltransferase (RosA): Molecular Dynamics Simulations and Residue Conservation Analysis

  2023cites this paper
• Transcriptional pause extension benefits the stand-by rather than catch-up Rho-dependent termination

  2023cites this paper
• A riboswitch separated from its ribosome-binding site still regulates translation

  2023cites this paper
• Transcriptional Interplay between Malassezia restricta and Staphylococcus Species Co-Existing in the Skin Environment

  2023cites this paper
• X-Ray Crystallography to Study Conformational Changes in a TPP Riboswitch.

  2023cites this paper
• Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity

  2022cites this paper
• A Riboswitch-Driven Era of New Antibacterials

  2022cites this paper
• Antimicrobial activity and mechanism of action of oregano essential oil against Morganella psychrotolerans and potential application in tuna

  2022cites this paper
• Extracellular electrons transferred from honey probiotic Bacillus circulans inhibits inflammatory acne vulgaris

  2022cites this paper
• Developing New Tools to Fight Human Pathogens: A Journey through the Advances in RNA Technologies

  2022cites this paper
• Examining the genomic features of human and plant-associated Burkholderia strains

  2022cites this paper
• RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth

  2022cites this paper
• Riboflavin as a promising antimicrobial agent? A multi-perspective review

  2022cites this paper
• Overview on Strategies and Assays for Antibiotic Discovery

  2022cites this paper
• Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand

  2021cites this paper
• A New Promising Anti-Infective Agent Inhibits Biofilm Growth by Targeting Simultaneously a Conserved RNA Function That Controls Multiple Genes

  2021cites this paper
• Riboswitches as Drug Targets for Antibiotics

  2021cites this paper
• Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.

  2021cites this paper
• Small molecule targeting of biologically relevant RNA tertiary and quaternary structures.

  2021cites this paper
• RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics.

  2021cites this paper
• Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.

  2021cites this paper
• Synthesis and evaluation of antimycobacterial activity of riboflavin derivatives.

  2021cites this paper
• An rfuABCD-Like Operon and Its Relationship to Riboflavin Utilization and Mammalian Infectivity by Borrelia burgdorferi

  2021cites this paper
• Antivitamine oder Trojanische Pferde in der Mikrobiologie

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• The promise of endogenous and exogenous riboflavin in anti-infection

  2021cites this paper
• MdaB and NfrA, Two Novel Reductases Important in the Survival and Persistence of the Major Enteropathogen Campylobacter jejuni

  2021cites this paper
• Deciphering the mechanism of action of 5FDQD and the design of new neutral analogues for the FMN riboswitch: a well-tempered metadynamics simulation study.

  2021cites this paper
• Riboswitches and aptamers: potential future targets to control drug-resistant bacteria

  2020cites this paper
• A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch.

  2020cites this paper
• Benefiting others and self: Production of vitamins in plants.

  2020cites this paper
• Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

  2020cites this paper
• Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums.

  2020cites this paper
• RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges

  2020cites this paper
• Mucosal-Associated Invariant T Cells as a Possible Target to Suppress Secondary Infections at COVID-19

  2020cites this paper
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  2020cites this paper
• Characterization of the Streptococcus mutans SMU.1703c-SMU.1702c Operon Reveals Its Role in Riboflavin Import and Response to Acid Stress

  2020cites this paper
• Metabolic engineering of roseoflavin-overproducing microorganisms

  2019cites this paper
• Discovery of Small‐Molecule Antibiotics against a Unique tRNA‐Mediated Regulation of Transcription in Gram‐Positive Bacteria

  2019cites this paper
• Riboflow: Using Deep Learning to Classify Riboswitches With ∼99% Accuracy

  2019cites this paper
• Nucleobase mutants of a bacterial preQ1-II riboswitch that uncouple metabolite sensing from gene regulation

  2019cites this paper
• Structural insights into the interactions of flavin mononucleotide (FMN) and riboflavin with FMN riboswitch: a molecular dynamics simulation study

  2019cites this paper
• Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery

  2019influential citation
• Transcriptomics reveals a cross-modulatory effect between riboflavin and iron and outlines responses to riboflavin biosynthesis and uptake in Vibrio cholerae

  2018cites this paper
• Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

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• Über bisherige Denkweisen hinaus - neue Wirkstoffe zur Überwindung der Antibiotika-Krise

  2018cites this paper
• Riboswitches as Molecular Tools for Microbial Bioprospecting

  2018cites this paper
• The New Versus Old Target Debate for Drug Discovery

  2018cites this paper
• Recent advances and future trends of riboswitches: attractive regulatory tools

  2018cites this paper
• Small molecules that target group II introns are potent antifungal agents

  2018cites this paper
• Superior cellular activities of azido- over amino-functionalized ligands for engineered preQ1 riboswitches in E.coli

  2018cites this paper
• Insights into the development of chemical probes for RNA

  2018cites this paper
• Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis.

  2018cites this paper
• Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis.

  2018cites this paper
• Hierarchical mechanism of amino acid sensing by the T-box riboswitch

  2018cites this paper
• Measuring RNA-Ligand Interactions with Microscale Thermophoresis.

  2018cites this paper
• Contribution of riboflavin supply pathways to Vibrio cholerae in different environments

  2017cites this paper
• Two Are Better Than One: Dual Targeting of Riboswitches by Metabolite Analogs.

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• Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria.

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