Supplementation with nanobubble water alleviates obesity-associated markers through modulation of gut microbiota in high-fat diet fed mice

Abstract This study aims to investigate the effects of nanobubble water (NBW) on the process of obesity in mice under high-fat diet (HFD). In the experimental groups, HFD feeding mice were supplemented with nitrogen NBW (HFD-N2) or hydrogen NBW (HFD-H2), while the mice fed with standard diet (SD-C) or HFD (HFD-C) supplementation with deionized water were used as control groups. After ten weeks, the concentrations of total cholesterol, alanine aminotransferase and lipopolysaccharide in the mice serum of the HFD-N2 group were significantly lower than those in the HFD-C group. 16S rRNA gene sequencing analysis of the community structures of fecal flora showed that supplementation with N2-NBW to the HFD fed mice could decrease the ratio of Firmicutes to Bacteroidetes. In conclusion, these results demonstrate that supplementation with N2-NBW potentially alleviates the development of obesity in HFD fed mice.

• Publication year

  2020

• Venue

  Journal of Functional Foods

• Publication date

  2020-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jff.2020.103820
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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