GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Endocrinology

• Publication date

  2016-03-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2015-1927PMID 26974005PMCID PMC4891789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

  2015cited by this paper
• GATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway.

  2015cited by this paper
• Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells.

  2015cited by this paper
• GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.

  2015cited by this paper
• The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

  2015cited by this paper
• Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis.

  2015cited by this paper
• Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling

  2015cited by this paper
• The Warburg Effect Revisited—Lesson from the Sertoli Cell

  2015cited by this paper
• Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells

  2014cited by this paper
• Spatial expression of claudin family members in various organs of mice.

  2014cited by this paper
• Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.

  2014cited by this paper
• Transgenic mouse models in the study of reproduction: insights into GATA protein function.

  2014cited by this paper
• The Dynamic of the Apical Ectoplasmic Specialization between Spermatids and Sertoli Cells: The Case of the Small GTPase Rap1

  2014cited by this paper
• GATA4 and GATA6 silencing in ovarian granulosa cells affects levels of mRNAs involved in steroidogenesis, extracellular structure organization, IGF-I activity, and apoptosis.

  2013cited by this paper
• CXCL12–CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells

  2013cited by this paper
• Gata4 Is Required for Formation of the Genital Ridge in Mice

  2013cited by this paper
• The Junctional Proteins Cingulin and Paracingulin Modulate the Expression of Tight Junction Protein Genes through GATA-4

  2013cited by this paper
• Metabolic regulation is important for spermatogenesis

  2012cited by this paper
• Cell lines

  2012cited by this paper
• GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.

  2012cited by this paper
• Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors.

  2012cited by this paper
• GATA4 Autoregulates Its Own Expression in Mouse Gonadal Cells via Its Distal 1b Promoter1

  2011cited by this paper
• GATA4 regulates Sertoli cell function and fertility in adult male mice.

  2011cited by this paper
• Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis.

  2011cited by this paper
• Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.

  2011cited by this paper
• Immunological, paracrine and endocrine aspects of testicular immune privilege.

  2011cited by this paper
• An in vitro system to study Sertoli cell blood-testis barrier dynamics.

  2011cited by this paper
• Androgen-induced Rhox homeobox genes modulate the expression of AR-regulated genes.

  2010cited by this paper
• Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay

  2009cited by this paper
• Apoptotic spermatogenic cells can be energy sources for Sertoli cells.

  2009cited by this paper
• Integrins are required for the differentiation of visceral endoderm

  2009cited by this paper
• GeNGe: systematic generation of gene regulatory networks

  2009cited by this paper
• Extracellular matrix and its role in spermatogenesis.

  2008cited by this paper
• Role of the GATA family of transcription factors in endocrine development, function, and disease.

  2008cited by this paper
• Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the kruppel family proteins, KLF4 and Sp1, in mouse TM4 sertoli cells

  2008cited by this paper
• Blood-testis barrier, junctional and transport proteins and spermatogenesis.

  2008cited by this paper
• The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.

  2007cited by this paper
• GATA‐4 is required for sex steroidogenic cell development in the fetal mouse

  2007cited by this paper
• Dual transcriptional control of claudin‐11 via an overlapping GATA/NF‐Y motif: Positive regulation through the interaction of GATA, NF‐YA, and CREB and negative regulation through the interaction of Smad, HDAC1, and mSin3A

  2007cited by this paper
• beadarray: R classes and methods for Illumina bead-based data

  2007cited by this paper
• Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice

  2007cited by this paper
• Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

  2006cited by this paper
• Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases

  2006cited by this paper
• Metabolism of amino acids by cultured rat Sertoli cells.

  2005cited by this paper
• limma: Linear Models for Microarray Data

  2005cited by this paper
• Evaluation of the Konelab 20XT clinical chemistry analyzer

  2005cited by this paper
• Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron.

  2005cited by this paper
• Extracellular Matrix: Recent Advances on Its Role in Junction Dynamics in the Seminiferous Epithelium During Spermatogenesis1

  2004cited by this paper
• Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis.

  2004cited by this paper
• Gata4 Regulates Testis Expression of Dmrt1

  2004cited by this paper
• Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells.

  2004cited by this paper
• Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.

  2004cited by this paper
• Lactate and energy metabolism in male germ cells.

  2004cited by this paper
• GATA4 is essential for formation of the proepicardium and regulates cardiogenesis.

  2004cited by this paper
• In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells.

  2004cited by this paper
• The interplay of collagen IV, tumor necrosis factor-alpha, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis.

  2003cited by this paper
• Differences in expression patterns between mouse connexin‐30.2 (Cx30.2) and its putative human orthologue, connexin‐31.9 1

  2003cited by this paper
• Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.

  2003cited by this paper
• Different patterns of anti‐Müllerian hormone expression, as related to DMRT1, SF‐1, WT1, GATA‐4, Wnt‐4, and Lhx9 expression, in the chick differentiating gonads

  2002cited by this paper
• Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.

  2002cited by this paper
• Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.

  2002cited by this paper
• Lactate inhibits germ cell apoptosis in the human testis.

  2002cited by this paper
• Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.

  2002cited by this paper
• Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.

  2001cited by this paper
• Temporal and Spatial Localization Patterns of Gata4 During Porcine Gonadogenesis1

  2001cited by this paper
• Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

  2000cited by this paper
• Passive Immunization with Anti-Laminin Immunoglobulin G Modifies the Integrity of the Seminiferous Epithelium and Induces Arrest of Spermatogenesis in the Guinea Pig1

  2000cited by this paper
• GATA-1 and GATA-4 transactivate inhibin/activin beta-B-subunit gene transcription in testicular cells.

  2000cited by this paper
• Unique and multifunctional adhesion junctions in the testis: ectoplasmic specializations.

  2000cited by this paper
• Improvement of spermatogenesis in adult cryptorchid rat testis by intratesticular infusion of lactate.

  1999cited by this paper
• Study on the formation of specialized inter‐Sertoli cell junctions in vitro

  1999cited by this paper
• Cluster analysis and display of genome-wide expression patterns.

  1998cited by this paper
• Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.

  1998cited by this paper
• Tumor necrosis factor-alpha-stimulated lactate production is linked to lactate dehydrogenase A expression and activity increase in porcine cultured Sertoli cells.

  1997cited by this paper
• Tumor Necrosis Factor-α-Stimulated Lactate Production Is Linked to Lactate Dehydrogenase A Expression and Activity Increase in Porcine Cultured Sertoli Cells.

  1997cited by this paper
• Basement membrane regulation of Sertoli cells.

  1994cited by this paper
• Development of Sertoli cell junctional specializations and the distribution of the tight-junction-associated protein ZO-1 in the mouse testis.

  1991cited by this paper
• Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis.

  1990cited by this paper
• Differential activity and synthesis of lactate dehydrogenase isozymes A (muscle), B (heart), and C (testis) in mouse spermatogenic cells.

  1989cited by this paper
• Metabolism of radiolabelled energy-yielding substrates by rat Sertoli cells.

  1986cited by this paper
• Establishment of gonadotropin-responsive murine leydig tumor cell line

  1982cited by this paper
• CULTURE OF TESTICULAR CELLS IN HORMONE‐SUPPLEMENTED SERUM‐FREE MEDIUM *

  1982cited by this paper
• Exogenous lactate is essential for metabolic activities in isolated rat spermatocytes and spermatids.

  1981cited by this paper
• Metabolism of glucose by Sertoli cells in culture.

  1981cited by this paper
• On the origin of cancer cells.

  1956cited by this paper
• [Origin of cancer cells].

  1956cited by this paper

• Spatiotemporal dynamics of spermatogenesis: insights from high-resolution spatial transcriptomics and pseudotime trajectories in mouse testes

  2026cites this paper
• Metabolic reprogramming and organelle quality control: the "silent" drivers of Sertoli cell dysfunction under environmental stressors.

  2026cites this paper
• Alcohol Alters Blood-testis Barrier Function in an in vitro Model.

  2025cites this paper
• Light-Based 3D Bioprinting of Testicular Organoid as an In Vitro Model for Reproductive Toxicity Assessment.

  2025cites this paper
• Characterization of somatic testicular cells during human development: fetal, peripubertal, adolescent and adult human testis from healthy and infertility related disease.

  2025cites this paper
• Bioengineering Approaches for Male Infertility: From Microenvironmental Regeneration to in vitro Fertilization.

  2025cites this paper
• A Review of Traditional Chinese Medicine Formulations and Natural Active Ingredients with Therapeutic Potential for Male Infertility Targeting Oxidative Stress

  2025cites this paper
• COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice

  2025cites this paper
• Integration of mRNA and MiRNA analysis reveals the molecular mechanisms of testicular development in newborn and adult sheep

  2025cites this paper
• Effects of diabetes-induced hyperglycemia on epigenetic modifications and DNA packaging and methylation during spermatogenesis; A narrative review

  2024cites this paper
• Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis

  2024cites this paper
• Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish

  2024cites this paper
• Single‐cell transcriptomic analysis reveals that the APP–CD74 axis promotes immunosuppression and progression of testicular tumors

  2024cites this paper
• Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C.

  2024cites this paper
• MAPKs signaling is obligatory for male reproductive function in a development-specific manner

  2024cites this paper
• In Vitro and In Vivo Models for Drug Transport Across the Blood-Testis Barrier

  2023cites this paper
• Relationships between the mutations of the goat GATA binding protein 4 gene and growth traits.

  2023cites this paper
• Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice.

  2023cites this paper
• Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA/isomiR profiles as sperm retrieval biomarkers for azoospermia

  2023cites this paper
• Regulation of STUB1 expression and its biological significance in mouse Sertoli cells

  2022cites this paper
• Metzincin Metalloproteases in PGC Migration and Gonadal Sex Conversion.

  2022cites this paper
• Bibliometric and visual analysis of blood-testis barrier research

  2022cites this paper
• Microbial conversion and biovalorization of fermented cassava waste biomass into livestock-based diets

  2022cites this paper
• Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM2.5.

  2022cites this paper
• Proteomic changes induced by ascorbic acid treatment on porcine immature Sertoli cells.

  2022cites this paper
• Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression

  2022cites this paper
• Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway

  2022cites this paper
• Heat treatment reduced the expression of miR-7-5p to facilitate insulin-stimulated lactate secretion by targeting IRS2 in boar Sertoli cells.

  2021cites this paper
• The role of different compounds on the integrity of blood-testis barrier: a concise review based on in vitro and in vivo studies.

  2021cites this paper
• ROS and metabolomics-mediated autophagy in rat's testicular tissue alter after exercise training; Evidence for exercise intensity and outcomes.

  2021cites this paper
• Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.

  2021cites this paper
• Effect of hyperglycemia on fertility in streptozotocin-induced diabetic male Wistar rats: focus on glucose transporters and oxidative stress

  2021cites this paper
• Alterations of mRNA and lncRNA profiles associated with the extracellular matrix and spermatogenesis in goats

  2021cites this paper
• Titanium dioxide nanoparticles perturb the blood-testis barrier via disruption of actin-based cell adhesive function

  2021cites this paper
• Flurochloridone induced abnormal spermatogenesis by damaging testicular Sertoli cells in mice.

  2021cites this paper
• Sodium-vitamin C-transporter-2 orchestrates lactate metabolism in mouse Sertoli cells.

  2020cites this paper
• OTT_A_238920 1787..1795

  2020cites this paper
• The Cellular Impact of the ZIKA Virus on Male Reproductive Tract Immunology and Physiology

  2020cites this paper
• Effects of 4% paraformaldehyde and modified Davidson’s fluid on the morphology and immunohistochemistry of Xiang pig testes

  2020cites this paper
• Phosphoglycerate Mutase 1: Its Glycolytic and Non-Glycolytic Roles in Tumor Malignant Behaviors and Potential Therapeutic Signi fi cance

  2020cites this paper
• Phosphoglycerate Mutase 1: Its Glycolytic and Non-Glycolytic Roles in Tumor Malignant Behaviors and Potential Therapeutic Signi fi cance

  2020cites this paper
• Phosphoglycerate Mutase 1: Its Glycolytic and Non-Glycolytic Roles in Tumor Malignant Behaviors and Potential Therapeutic Significance

  2020cites this paper
• PFKP Signaling at a Glance: An Emerging Mediator of Cancer Cell Metabolism.

  2019cites this paper
• Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation.

  2019cites this paper
• Transcriptomic analysis of overexpressed SOX4 and SOX8 in TM4 Sertoli cells with emphasis on cell-to-cell interactions.

  2019cites this paper
• Effect of tert-butyl hydroperoxide in testicular metabolism

  2019cites this paper
• Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice†

  2019cites this paper
• Differential Regulation of TLE3 in Sertoli Cells of the Testes during Postnatal Development

  2019cites this paper
• ERK1/2 regulates heat stress-induced lactate production via enhancing the expression of HSP70 in immature boar Sertoli cells

  2018cites this paper
• Gene expression profiles of glucose toxicity‐exposed islet microvascular endothelial cells

  2018cites this paper
• GATA4 is a negative regulator of contractility in testicular peritubular myoid cells.

  2018cites this paper
• Interference with lactate metabolism by mmu-miR-320-3p via negatively regulating GLUT3 signaling in mouse Sertoli cells

  2018cites this paper
• Validation and Automation of a High-Throughput Multitargeted Method for Semiquantification of Endogenous Metabolites from Different Biological Matrices Using Tandem Mass Spectrometry

  2018cites this paper
• Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells

  2018cites this paper
• Glucose and glutamine handling in the Sertoli cells of transgenic rats overexpressing regucalcin: plasticity towards lactate production

  2018cites this paper
• Comparison of Hematopoietic and Spermatogonial Stem Cell Niches from the Regenerative Medicine Aspect.

  2018cites this paper
• Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox

  2017cites this paper
• Régulation de l'activité du promoteur distal 1b du gène Gata4

  2017cites this paper
• Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.

  2017cites this paper