Expression of mutant protein p53 and Hsp70 and Hsp90 chaperones in cockles Cerastoderma edule affected by neoplasia.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Diseases of Aquatic Organisms

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3354/dao02231PMID 20815330
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
• Detection of mutant p53 in clam leukemia cells.

  1997cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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• The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner.

  1990cited by this paper
• Hematopoietic neoplasia inMya arenaria: Prevalence and indices of physiological condition

  1990cited by this paper
• Transmission of a sarcoma in the cockle Cerastoderma edule (Bivalvia; Mollusca) using cell transplants.

  1988cited by this paper
• Sarcomatous lesion in the cockle Cerastoderma edule: II. Electron microscopical study

  1986cited by this paper
• Sarcomatous lesion in the cockle Cerastoderma edule: I. Morphology and population survey in Brittany, France

  1986cited by this paper
• A proliferative disorder of possible hemic origin in the common cockle

  1984cited by this paper
• 5-bromodeoxyuridine induction of hematopoietic neoplasia and retrovirus activation in the soft-shell clam, Mya arenaria.

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• Accuracy of blood cytological screening techniques for the diagnosis of a possible hematopoietic neoplasm in the bivalve mollusc, Mya arenaria

  1982cited by this paper
• Isolation of a viral agent causing hematopoietic neoplasia in the soft-shell clam,

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• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

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  2017cites this paper
• Widespread transmission of independent cancer lineages within multiple bivalve species

  2016cites this paper
• Neoplastic diseases of marine bivalves.

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2013cites this paper
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