Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  International journal of pharmaceutics

• Publication date

  2012-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ijpharm.2011.06.022PMID 21718766PMCID PMC3207009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cationic amphiphiles with fatty acyl chain asymmetry of coconut oil deliver genes selectively to mouse lung.

  2011cited by this paper
• Lipoplexes formulation and optimisation: in vitro transfection studies reveal no correlation with in vivo vaccination studies.

  2010cited by this paper
• The benefit of hydrophobic domain asymmetry on the efficacy of transfection as measured by in vivo imaging.

  2010cited by this paper
• Medicinal chemistry of siRNA delivery.

  2010cited by this paper
• Hydrophobic moiety of cationic lipids strongly modulates their transfection activity.

  2009cited by this paper
• Exploitation of De Novo helper-lipids for effective gene delivery.

  2009cited by this paper
• Cholesterol domains in cationic lipid/DNA complexes improve transfection.

  2008cited by this paper
• A new helper phospholipid for gene delivery.

  2008cited by this paper
• In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation.

  2008cited by this paper
• Lipid-based Nanoparticles for Nucleic Acid Delivery

  2007cited by this paper
• Nonviral gene delivery: What we know and what is next

  2007cited by this paper
• Assembly of nucleic acid-lipid nanoparticles from aqueous-organic monophases.

  2006cited by this paper
• Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers.

  2005cited by this paper
• Lipid Mixing between Lipoplexes and Plasma Lipoproteins Is a Major Barrier for Intravenous Transfection Mediated by Cationic Lipids*

  2005cited by this paper
• Low‐pH‐sensitive poly(ethylene glycol) (PEG)‐stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery

  2005cited by this paper
• New strategy for transfection: mixtures of medium-chain and long-chain cationic lipids synergistically enhance transfection

  2004cited by this paper
• Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy

  2003cited by this paper
• Chemical approaches to triggerable lipid vesicles for drug and gene delivery.

  2003cited by this paper
• Cationic transfection lipids.

  2003cited by this paper
• Lipoplex-induced hemagglutination: potential involvement in intravenous gene delivery

  2002cited by this paper
• In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy

  2002cited by this paper
• Biophysical Aspects of Using Liposomes as Delivery Vehicles

  2002cited by this paper
• Biophysical and transfection studies of the diC(14)-amidine/DNA complex.

  2002cited by this paper
• Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency.

  2002cited by this paper
• In vitro cationic lipid-mediated gene delivery with fluorinated glycerophosphoethanolamine helper lipids.

  2001cited by this paper
• Cationic lipid-mediated transfection in vitro and in vivo

  2001cited by this paper
• Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

  2001cited by this paper
• Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system.

  2001cited by this paper
• Mechanism of lipoplex gene delivery in mouse lung: binding and internalization of fluorescent lipid and DNA components

  2001cited by this paper
• On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

  2001cited by this paper
• Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchrotron X-Ray Diffraction

  1999cited by this paper
• An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery.

  1998cited by this paper
• Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery

  1997cited by this paper
• Effect of co-lipids in enhancing cationic lipid-mediated gene transfer in vitro and in vivo

  1997cited by this paper
• The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids

  1997cited by this paper
• The role of helper lipids in cationic liposome-mediated gene transfer.

  1996cited by this paper
• Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection.

  1996cited by this paper
• Strategies for the synthesis of glycerophospholipids.

  1994cited by this paper
• Preparation of alkyl ether and vinyl ether substrates for phospholipases.

  1991cited by this paper
• Universality in interacting membranes: The effect of cosurfactants on the interfacial rigidity.

  1989cited by this paper
• Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

  1987cited by this paper

• Mono‐Alkyl Etherification of Glycerol Acetonide as Glycerol Alternative with Epoxides

  2025cites this paper
• Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids.

  2019cites this paper
• Cationic Nanoparticles Assembled from Natural-Based Steroid Lipid for Improved Intracellular Transport of siRNA and pDNA

  2016cites this paper
• trans-2-Aminocyclohexanol-based amphiphiles as highly efficient helper lipids for gene delivery by lipoplexes.

  2015cites this paper
• Physicochemical and biological characterization of 1,2-dialkoylamidopropane-based lipoplexes for gene delivery.

  2015cites this paper
• Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies.

  2015cites this paper
• Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.

  2014cites this paper
• Intracellular trafficking mechanism of cationic phospholipids including cationic liposomes in HeLa cells.

  2014cites this paper
• Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo

  2014cites this paper
• Natural or synthetic nucleic acids encapsulated in a closed cavity of amphiphiles

  2013cites this paper
• Technologies for Investigating the Physiological Barriers to Efficient Lipid Nanoparticle–siRNA Delivery

  2013cites this paper
• Recent progress in non-viral nucleic acids delivery.

  2012cites this paper
• Lipoplexes formulation and optimisation: in vitro transfection studies reveal no correlation with in vivo vaccination studies.

  2010cites this paper