Clinical and Radiographic Effects of Bone Marrow Derived Mesenchymal Stem Cells Along with Local Insulin Therapy in Healing of Segmental Bone Defect in Diabetic Rabbits

The objective of present study was to investigate the efficacy of cultured allogenic bone marrow derived mesenchymal stem cell (BMMSCs) implant with insulin therapy for increasing osteosynthesis in bone gap defects in diabetic rabbits. Thirty six, clinically healthy New Zealand White rabbits were divided into four groups: A, B, C and D. Diabetes was induced experimentally in all rabbits, except group A. A 5 mm bone defect was created in right radii of all rabbits and following treatment was given: hydroxyapatite granules (group A and B), hydroxyapatite granules and insulin therapy (group C), cultured allogenic BMMSCs in hydroxyapatite scaffold and insulin therapy (group D). Clinical and radiographic parameters were recorded at days 0, 30, 60 and 90. It may be conducted that cultured allogenic bone marrow derived mesenchymal stem cells in hydroxyapatite scaffold along with local insulin therapy produces faster and better healing in alloxan-induced diabetic rabbits compared to healthy control, untreated diabetic and local insulin treated groups.

• Publication year

  2019

• Venue

  Indian Journal of Animal Research

• Publication date

  2019-12-30

• Fields of study

  Medicine

• Identifiers
  DOI 10.18805/ijar.b-3900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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