Growth and production modeling in hybridoma continuous cultures

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Biotechnology and Bioengineering

• Publication date

  1993-12-01

• Fields of study

  Mathematics, Medicine

• Identifiers
  DOI 10.1002/bit.260421109PMID 18612960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH

  2000cited by this paper
• Effect of dilution rate on growth, productivity, cell cycle and size, and shear sensitivity of a hybridoma cell in a continuous culture

  1993cited by this paper
• Cell cycle model for growth rate and death rate in continuous suspension hybridoma cultures

  1992cited by this paper
• Determination of antibody content in live versus dead hybridoma cells: Analysis of antibody production in osmotically stressed cultures

  1992cited by this paper
• The effect of specific growth rate and death rate on monoclonal antibody production in hybridoma chemostat cultures

  1991cited by this paper
• Cell cycle‐ and growth phase‐dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures

  1990cited by this paper
• Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures.

  1990cited by this paper
• Cell cycle model for antibody production kinetics.

  1989cited by this paper
• Cultivation of hybridoma cells in continuous cultures: Kinetics of growth and product formation

  1989cited by this paper
• Cell cycle modelling.

  1986cited by this paper
• Do cells cycle?

  1973cited by this paper
• Grain count distributions in labeled cell populations.

  1969cited by this paper

• Modelling of Mammalian Cell Cultures

  2015cites this paper
• Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells

  2015cites this paper
• An unstructured model of metabolic and temperature dependent cell cycle arrest in hybridoma batch and fed-batch cultures

  2015cites this paper
• Impact of Process Parameters on Cell Growth, Metabolism and Antibody Glycosylation

  2014cites this paper
• Developing a cyclin blueprint as a tool for mapping the cell cycle in GS-NS0

  2013cites this paper
• Development of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation

  2013cites this paper
• Genomics and Systems Biology of Mammalian Cell Culture

  2012cites this paper
• Modeling metabolic networks for mammalian cell systems: general considerations, modeling strategies, and available tools.

  2012cites this paper
• Animal Cell Technology: From Biopharmaceuticals to Gene Therapy

  2009cites this paper
• A Self‐Feeding Roller Bottle for Continuous Cell Culture

  2008cites this paper
• Three-dimensional cell cycle model with distributed transcription and translation

  2006cites this paper
• Modeling of cell culture processes

  2004cites this paper
• Modelling of Mammalian Cells and Cell Culture Processes

  2004cites this paper
• Use of cell cycle analysis in early state estimation and process control

  2003cites this paper
• Macroscopic Modelling of Bioprocesses with a View to Engineering Applications

  2001cites this paper
• Apoptosis-resistant E1B-19K-expressing NS/0 myeloma cells exhibit increased viability and chimeric antibody productivity under perfusion culture conditions.

  1999cites this paper
• Characterization of cell population growth by cell cycle parameters.

  1999cites this paper
• Apoptosis-resistant NS/0 E1B-19K myelomas exhibit increased viability and chimeric antibody productivity under cell cycle modulating conditions

  1998cites this paper
• Transition probability cell cycle model with product formation.

  1998cites this paper
• Regulation of glucose and glutamine uptake and the production of monoclonal antibody in hybridoma cultures

  1997cites this paper
• A combined cell‐cycle and metabolic model for the growth of hybridoma cells in steady‐state continuous culture

  1995cites this paper
• Simulation of Cell Cycle Dependent Growth and Metabolism in Animal Cell Fermentation

  1995cites this paper