Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular Carcinogenesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mc.2940050306PMID 1316758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Increased cell division as a cause of human cancer.

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  1988cited by this paper
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  2002cites this paper
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  2001cites this paper
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  2000cites this paper
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  1999cites this paper
• Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats

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• Chronic liver injury promotes hepatocarcinogenesis of the LEC rat.

  1998cites this paper
• The LEC rat possesses reduced hepatic selenium, contributing to the severity of spontaneous hepatitis and sensitivity to carcinogenesis.

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• Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.

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• Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.

  1997cites this paper
• Copper-dependent formation of miscoding etheno-DNA adducts in the liver of Long Evans cinnamon (LEC) rats developing hereditary hepatitis and hepatocellular carcinoma.

  1996influential citation
• Inhibition of hereditary hepatitis and liver tumor development in Long‐Evans cinnamon rats by the copper‐chelating agent trientine dihydrochloride

  1996cites this paper
• Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline

  1996cites this paper
• Failure of copper incorporation into ceruloplasmin in the Golgi apparatus of LEC rat hepatocytes.

  1995cites this paper
• The high hepatocarcinogen susceptibility of LEC rats is genetically independent of abnormal copper accumulation in the liver.

  1995cites this paper
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• Deletion of the Wilson's disease gene in hereditary hepatitis LEC rats

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  1995cites this paper
• The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene

  1994cites this paper
• The LEC rat: a model for human hepatitis, liver cancer, and much more.

  1994cites this paper
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• Role of copper accumulation and metallothionein induction in spontaneous liver cancer development in LEC rats.

  1994cites this paper
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